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21.
Allan P. Engsig-Karup Jan S. Hesthaven Harry B. Bingham Per A. Madsen 《Journal of Engineering Mathematics》2006,56(3):351-370
A discontinuous Galerkin finite-element method (DG-FEM) solution to a set of high-order Boussinesq-type equations for modelling
highly nonlinear and dispersive water waves in one horizontal dimension is presented. The continuous equations are discretized
using nodal polynomial basis functions of arbitrary order in space on each element of an unstructured computational domain.
A fourth-order explicit Runge-Kutta scheme is used to advance the solution in time. Methods for introducing artificial damping
to control mild nonlinear instabilities are also discussed. The accuracy and convergence of the model with both h (grid size) and p (order) refinement are confirmed for the linearized equations, and calculations are provided for two nonlinear test cases
in one horizontal dimension: harmonic generation over a submerged bar, and reflection of a steep solitary wave from a vertical
wall. Test cases for two horizontal dimensions will be considered in future work. 相似文献
22.
Measurements of transcutaneous oxygen tension, transcutaneous carbon dioxide tension, transcutaneous heater power, transcutaneous electrode temperature, and peripheral perfusion at the gas measurement site (assessed by laser Doppler velocimetry) are monitored by a microprocessor-based data acquisition system. Arterial blood pressure, central venous pressure, pulmonary artery pressure, respiration rate, and heart rate may be simultaneously captured with the system unattended for 12-hour intervals. This computerized monitoring system is mobile and easily applied by medical technologists to adult or neonatal intensive care patients. Simultaneous collection of the measurement data has facilitated research on the interrelationships of the measured parameters. It should be helpful in assessing optimal therapeutic interventions as well as the changing physiology of acutely ill patients. 相似文献
23.
Emad A. Ahmed Peramaiyan Rajendran Harry Scherthan 《International journal of molecular sciences》2022,23(11)
MicroRNA-202 (miR-202) is a member of the highly conserved let-7 family that was discovered in Caenorhabditis elegans and recently reported to be involved in cell differentiation and tumor biology. In humans, miR-202 was initially identified in the testis where it was suggested to play a role in spermatogenesis. Subsequent research showed that miR-202 is one of the micro-RNAs that are dysregulated in different types of cancer. During the last decade, a large number of investigations has fortified a role for miR-202 in cancer. However, its functions can be double-edged, depending on context they may be tumor suppressive or oncogenic. In this review, we highlight miR-202 as a potential diagnostic biomarker and as a suppressor of tumorigenesis and metastasis in several types of tumors. We link miR-202 expression levels in tumor types to its involved upstream and downstream signaling molecules and highlight its potential roles in carcinogenesis. Three well-known upstream long non-coding-RNAs (lncRNAs); MALAT1, NORAD, and NEAT1 target miR-202 and inhibit its tumor suppressive function thus fueling cancer progression. Studies on the downstream targets of miR-202 revealed PTEN, AKT, and various oncogenes such as metadherin (MTDH), MYCN, Forkhead box protein R2 (FOXR2) and Kirsten rat sarcoma virus (KRAS). Interestingly, an upregulated level of miR-202 was shown by most of the studies that estimated its expression level in blood or serum of cancer patients, especially in breast cancer. Reduced expression levels of miR-202 in tumor tissues were found to be associated with progression of different types of cancer. It seems likely that miR-202 is embedded in a complex regulatory network related to the nature and the sensitivity of the tumor type and therapeutic (pre)treatments. Its variable roles in tumorigenesis are mediated in part thought its oncogene effectors. However, the currently available data suggest that the involved signaling pathways determine the anti- or pro-tumorigenic outcomes of miR-202’s dysregulation and its value as a diagnostic biomarker. 相似文献
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Dora Y. Chakraborty A. Heikman S. McCarthy L. Keller S. DenBaars S.P. Mishra U.K. 《Electron Device Letters, IEEE》2006,27(7):529-531
The effect of ohmic contacts on the buffer leakage of GaN transistors is presented. The buffer leakage for AlGaN/GaN high-electron mobility transistors and GaN MESFETs grown on the same underlying buffer was observed to be different. Controlled experiments show that the increased buffer leakage is due to the nature of the alloyed ohmic contacts and can be minimized if they are screened by the Si doping or by the two-dimensional electron gas. 相似文献
29.
This paper describes a computer tool for site specific indoor radio channel characterization. The behavior of the electromagnetic fields associated with a base station and a portable radio unit is simulated by combining approximate geometric optics and ray tracing techniques. Given a building plan and the transmitter/receiver locations, the set of all[attenuation / time delay /phase] vectors, each representing an electromagnetic propagation path between transmitter and receiver, is computed using ray shooting techniques to generate the channel wideband impulse response. The model takes into account specular reflection and transmission. Linear polarization and various antenna patterns can be simulated as well. The simulated results are shown to correlate well with experimental data. The computer tool can be used to provide estimates of the coverage of a base station and of the channel quality. 相似文献
30.
根据莫尔(Moore)定律,半导体集成电路芯片上的晶体管的数量每隔18个月将会增加一倍,这对我们在日常生活中使用电子学线路的大多数人来说,无疑是一个很好的消息.但是,对美国高级微型器件公司的Brennan Davis实验室来说,它意味着"干草堆"变得越来越大,而"针子"变得越来越小(意思是在芯片上寻找故障或缺陷更难,犹如大海捞针-译者注).Davis实验室检测封装的晶体管芯片,以验证那些不合格、有缺陷的逻辑电路,或验证那些接触不良的接点.检测的工具之一是采用由美国Sensors传感器无限公司研制的、基于InGaAs的红外摄像机(红外相机). 相似文献