Market perspectives of stationary fuel cells in a sustainable energy supply system—long-term scenarios for Germany

Because of high efficiency, low environmental impacts and a potential role in transforming our energy system into a hydrogen economy, fuel cells are often considered as a key technology for a sustainable energy supply. However, the future framing conditions under which stationary fuel cells have to prove their technical and economic competitiveness are most likely characterised by a reduced demand for space heating, and a growing contribution of renewable energy sources to heat and electricity supply, which both directly limit the potential for combined heat and power generation, and thus also for fuel cells. Taking Germany as a case study, this paper explores the market potential of stationary fuel cells under the structural changes of the energy demand and supply system required to achieve a sustainable energy supply. Results indicate that among the scenarios analysed it is in particular a strategy oriented towards ambitious CO₂-reduction targets, which due to its changes in the supply structure is in a position to mobilise a market potential that might be large enough for a successful fuel cell commercialisation. However, under the conditions of a business-as-usual trajectory the sales targets of fuel cell manufacturers cannot be met.     

Conditioned and unconditioned fear organized in the inferior colliculus are differentially sensitive to injections of muscimol into the basolateral nucleus of the amygdala.

Chemical stimulation of the inferior colliculus (IC) with semicarbazide--an inhibitor of the gamma aminobutyric acid synthesizing enzyme--functions as an unconditioned stimulus in the conditioned place aversion test (CPA), and electrolytic lesions of the basolateral amygdala (BLA) enhance the aversiveness of the IC stimulation. This study examined the effects of inactivation of the BLA with muscimol on the conditioned and unconditioned fear using semicarbazide injections into the IC of rats subjected to conditioned (CPA) or unconditioned (open field) fear tests. In both tests, the rats were injected with semicarbazide or saline into the IC and muscimol or saline into the BLA. Muscimol decreased the CPA and increased the unconditioned fear elicited by IC injections of semicarbazide. These findings indicate that distinct modulatory mechanisms in the BLA are recruited during the conditioned and unconditioned fear triggered by IC activation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A high-risk method for studying psychosocial antecedents of chronic pain: The prospective investigation of herpes zoster.

Although patients with chronic pain (CP) are often psychologically distressed, it has been difficult to determine whether this distress is an antecedent of CP or whether it is caused by the experience of living with CP. This investigation aimed to develop a method that would allow individuals who are at risk for the development of CP to be studied before the pain has become chronic. Patients with acute herpes zoster (HZ) were assessed with demographic, medical, pain, and psychosocial measures. Pain was assessed in follow-up interviews at 6 wks and 3, 5, 8, and 12 mo after these initial assessments. There were no significant differences between Ss who developed short-term HZ pain and Ss who did not develop short-term pain for any of the measures at the initial assessment, except for 1 measure of pain intensity. Ss who developed HZ CP, however, had significantly greater pain intensity, higher state and trait anxiety, greater depression, lower life satisfaction, and greater disease conviction at the initial assessment than Ss who did not develop CP. In discriminant analyses, disease conviction, pain intensity, and state anxiety each made a unique contribution to discriminating Ss who did and did not develop CP. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structure prediction of subtilisin BPN' mutants using molecular dynamics methods

In this paper we describe the achievements and pitfalls encounteredin doing structure predictions of protein mutants using moleculardynamics simulation techniques in which properties of atomsare slowly changed as a function of time. Basically the methodconsists of a thermodynamic integration (slow growth) calculationused for free energy determination, but aimed at structure prediction;this allows for a fast determination of the mutant structure.We compared the calculated structure of the mutants Met222Ala,Met222Phe and Met222Gln of subtilisin BPN' with the respectiveX-ray structures and found good agreement between predictedand X-ray structure. The conformation of the residue subjectto the mutation is relatively easy to predict and is mainlydetermined by packing criteria. When the side chain has polargroups its exact orientation may pose problems; long-range Coulombinteractions may generate a polarization feedback involvingsystem relaxation times beyond the simulation time. Changesinduced in the environment are harder to predict using thismethod. In particular, rearrangement of the hydration structurewas difficult to predict correctly, probably because of thelong relaxation times. In all conversions made the changes observedin the environment were found to be history-dependent and inparticular the hydrogen bonding patterns provided evidence formetastable substates. In all cases the structure predicted wascompared with available kinetic data and the reduced activitycould be explained in terms of changes in the configurationof the active site.     

Towards Analyzing and Synthesizing Protocols

The production of error-free protocols or complex process interactions is essential to reliable communications. This paper presents techniques for both the detection of errors in protocols and for prevention of errors in their design. The methods have been used successfully to detect and correct errors in existing protocols. A technique based on a reachability analysis is described which detects errors m a design. This "perturbation technique" has been implemented and has successfully detected inconsistencies or errors in existing protocol designs including both X.21 and X.25. The types of errors handled are state deadlocks, unspecified receptions, nonexecutable interactions, and state smbiguities. These errors are discussed and their effects considered. An interactive design technique is then described that prevents design errors. The technique is based on a set of production rules which guarantee that complete reception capability is provided in the interacting processes. These rules have been implemented in the form of a tracking algorithm that prevents a designer from creating unspecified receptions and nonexecutable interactions and monitors for the presence of state deadlocks and ambiguities.