High sodium intake decreases pressure-induced (myogenic) tone and flow-induced dilation in resistance arteries from hypertensive rats

A real-time automated way of quantifying metabolites from in vivo NMR spectra using an artificial neural network (ANN) analysis is presented. The spectral training and test sets for ANN containing peaks at the chemical shift ranges resembling long echo time proton NMR spectra from human brain were simulated. The performance of the ANN constructed was compared with an established lineshape fitting (LF) analysis using both simulated and experimental spectral data as inputs. The correspondence between the ANN and LF analyses showed correlation coefficients of order of 0.915-0.997 for spectra with large variations in both signal-to-noise and peak areas. Water suppressed 1H NMR spectra from 24 healthy subjects were collected and choline-containing compounds (Cho), total creatine (Cr), and N-acetyl aspartate (NAA) were quantified with both methods. The ANN quantified these spectra with an accuracy similar to LF analysis (correlation coefficients of 0.915-0.951). These results show that LF and ANN are equally good quantifiers; however, the ANN analyses are more easily automated than LF analyses.     

Stabilization via Nonsmooth, Nonconvex Optimization

Nonsmooth variational analysis and related computational methods are powerful tools that can be effectively applied to identify local minimizers of nonconvex optimization problems arising in fixed-order controller design. We support this claim by applying nonsmooth analysis and methods to a challenging "Belgian chocolate" stabilization problem posed in 1994: find a stable, minimum phase, rational controller that stabilizes a specified second-order plant. Although easily stated, this particular problem remained unsolved until 2002, when a solution was found using an eleventh-order controller. Our computational methods find a stabilizing third-order controller without difficulty, suggesting explicit formulas for the controller and for the closed loop system, which has only one pole with multiplicity 5. Furthermore, our analytical techniques prove that this controller is locally optimal in the sense that there is no nearby controller with the same order for which the closed loop system has all its poles further left in the complex plane. Although the focus of the paper is stabilization, once a stabilizing controller is obtained, the same computational techniques can be used to optimize various measures of the closed loop system, including its complex stability radius or H_infin performance     

Effect of channel-confinement and aiding/opposing buoyancy on the two-dimensional laminar flow and heat transfer across a square cylinder

The effect of channel-confinement of various degree (blockage ratio of 10%, 30% and 50%) on the upward flow and heat transfer characteristics around a heated/cooled square cylinder is studied by considering the effect of aiding/opposing buoyancy at −1 Ri 1, for Re = 100 and Pr = 0.7. With increasing blockage ratio, the minimum heating (critical Ri) required for the suppression of vortex shedding decreases up to a certain blockage ratio (=30%), but thereafter increases. The influence of buoyancy and channel-confinement on the recirculation length, drag and lift coefficient, pumping power, Strouhal number and heat transfer from the cylinder, is also investigated.     

Hepatocellular carcinoma associated with precocious puberty and oral contraceptives. A case report

A 36-year-old woman presented with sudden abdominal pain and vomiting. Computed tomography showed a tumour of the right hepatic lobe with possible signs of acute haemorrhage. Her medical history revealed precocious puberty when she was a 5-year-old and the use of oral contraceptives for 18 years. Bisegmentectomy was performed and histological examination revealed hepatocellular carcinoma. The role of male and female sex hormones in the development of hepatic tumours has been well documented but, to our knowledge, association with precocious puberty has not yet been described.     

Realization of multidimensional digital transfer functions

The various possibilities that exist for obtaining multidimensional digital filters using the direct approach are investigated and a methodical synthesis procedure is developed. Then a theorem which can be used to obtain filters with fewer delay elements for a specific class of multidimensional filters is presented. The synthesis procedure is illustrated by examples.This work was supported by the Natural Sciences and Engineering Research Council of Canada.     

NRSE potential in India

India's paper presented at the UN Conference on New and Renewable Sources of Energy stressed the large potential for NRSE in India. The author contends however that the potential for biomass in India has been under estimated. He also stresses the need for an immediate conservation programme.     

Wet-chemical passivation and characterization of silicon interfaces for solar cell applications

The interface properties of silicon solar cell structures were characterized by the two non-destructive and highly surface-sensitive spectroscopic techniques: surface photovoltage and spectroscopic ellipsometry. The resulting charge and density of interface states as well as the microscopic surface roughness and oxide coverage were investigated during silicon wafer preparation and during sample storage in air. The surface state density of hydrogen-terminated silicon surfaces as well as the long-time stability of the hydrogen termination were found to primarily depend on the surface morphology resulting from the wet-chemical oxidation procedures applied before. The smallest interface state densities were obtained by NH₄F treatment subsequent to oxidation in ultra-pure water at 80°C. Surfaces prepared using this procedure are found to be much more stable upon exposition to clean-room air than those prepared by conventionally prepared H-terminated surfaces.The successful application of the new passivation procedures in photovoltaics is shown for selected examples of different solar cell concepts.     

Shared memory in design: A unifying theme for research and practice

This paper presents a new unifying theme for design theory by emphasizing the importance of context. We arrive at our conclusions by examining and then criticizing the legitimacy of universal methods in design upon which the critical importance of context emerges. The collaborative aspects of design focuses attention on the conception of shared meaning. We introduce and elaborate the concept of shared memory as the embodiment both of context and of shared meaning. Using the concept of shared memory in vertical and horizontal forms, within and between disciplines, respectively, we both account for past observations of design in practice and recommend actions to improve design in the future. We examine several practical implications of the growing importance of shared memory in industrial firms and for design teams. We then consider and recommend specific research programs which will help designers capture and make better use of this critical resource.