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排序方式： 共有154条查询结果，搜索用时 15 毫秒
81.
Chinatsu Nishida Hiroto Izumi Taisuke Tomonaga Ke-Yong Wang Hidenori Higashi Jun-Ichi Takeshita Ryohei Ono Kazuki Sumiya Shota Fujii Yuki Hata Kazuo Sakurai Yasuyuki Higashi Kei Yamasaki Kazuhiro Yatera Yasuo Morimoto 《International journal of molecular sciences》2022,23(18)
Background: We conducted intratracheal instillations of different molecular weights of polyacrylic acid (PAA) into rats in order to examine what kinds of physicochemical characteristics of acrylic acid-based polymer affect responses in the lung. Methods: F344 rats were intratracheally exposed to a high molecular weight (HMW) of 598 thousand g/mol or a low molecular weight (LMW) of 30.9 thousand g/mol PAA at low and high doses. Rats were sacrificed at 3 days, 1 week, 1 month, 3 months and 6 months post exposure. Results: HMW PAA caused persistent increases in neutrophil influx, cytokine-induced neutrophil chemoattractants (CINC) in the bronchoalveolar lavage fluid (BALF), and heme oxygenase-1 (HO-1) in the lung tissue from 3 days to 3 months and 6 months following instillation. On the other hand, LMW PAA caused only transient increases in neutrophil influx, CINC in BALF, and HO-1 in the lung tissue from 3 days to up to 1 week or 1 month following instillation. Histopathological findings of the lungs demonstrated that the extensive inflammation and fibrotic changes caused by the HMW PAA was greater than that in exposure to the LMW PAA during the observation period. Conclusion: HMW PAA induced persistence of lung disorder, suggesting that molecular weight is a physicochemical characteristic of PAA-induced lung disorder. 相似文献
82.
Ayako Ohyama Atsumu Osada Hoshimi Kawaguchi Izumi Kurata Taihei Nishiyama Tamaki Iwai Akihito Ishigami Yuya Kondo Hiroto Tsuboi Takayuki Sumida Isao Matsumoto 《International journal of molecular sciences》2021,22(14)
Neutrophils and their extracellular traps have been shown to play an important role in the pathogenesis of rheumatoid arthritis (RA), but the detailed mechanisms in joints are still unclear, and their regulation remains to be solved. Here, we explored neutrophil extracellular trap (NET)osis in experimental models of arthritis and further investigated the effects of interleukin-6 (IL-6) inhibition in neutrophils and NETosis. In skins of peptide GPI-induced arthritis (pGIA), citrullinated protein was detected as well as citrullinated histone expression in immunized skin but this was not specific to pGIA. Citrullinated histone expression in pGIA joints was specific to pGIA and was merged with neutrophil elastase, suggesting NETosis. Neutrophils in joints tend to upregulate IL-6 receptors when compared with bone marrow neutrophils. Administration of mouse anti-IL-6 receptor antibodies in pGIA suppressed arthritis in association with a decrease in neutrophil infiltration and NETosis in joints. In the plasma of RA patients, citrullinated protein was significantly reduced after tocilizumab treatment. Our results suggest that IL-6 enhances neutrophil chemotaxis and NETosis in inflammatory joints and could be the source of citrullinated proteins. 相似文献
83.
Observations of boiling behaviors and measurements of critical heat flux (CHF) were carried out for saturated water boiling on a horizontal, upward-facing plate at pressures from atmospheric to 7 MPa. The primary bubbles diminish in size almost in inverse proportion to pressure and commence to coalesce in the very low heat flux region. The diameter of detached coalesced bubbles increases with increases in the heat flux and reaches about 10 mm even at a pressure of 5 MPa. Detachment frequency of the coalesced bubbles was unaffected by the heat flux and pressure. The CHF predicted based on the macrolayer dryout model agrees well with the measured data. 相似文献
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86.
Toya Okawa Kurumi Hara Momoko Goto Moe Kikuchi Masataka Kogane Hiroto Hatakeyama Hiroki Tanaka Daiki Shirane Hidetaka Akita Akihiro Hisaka Hiromi Sato 《International journal of molecular sciences》2021,22(16)
The second messenger 2′3′-cyclic-GMP-AMP (cGAMP) is thought to be transmitted from brain carcinomas to astrocytes via gap junctions, which functions to promote metastasis in the brain parenchyma. In the current study, we established a method to introduce cGAMP into astrocytes, which simulates the state of astrocytes that have been invaded by cGAMP around tumors. Astrocytes incorporating cGAMP were analyzed by metabolomics, which demonstrated that cGAMP increased glutamate production and astrocyte secretion. The same trend was observed for γ-aminobutyric acid (GABA). Conversely, glutamine production and secretion were decreased by cGAMP treatment. Due to the fundamental role of astrocytes in regulation of the glutamine–glutamate cycle, such metabolic changes may represent a potential mechanism and therapeutic target for alteration of the central nervous system (CNS) environment and the malignant transformation of brain carcinomas. 相似文献
87.
Chao Sun Xiaoyu Wang Yangyang Hui Hirokazu Fukui Bangmao Wang Hiroto Miwa 《International journal of molecular sciences》2021,22(13)
Regenerating gene (REG) family proteins serve as multifunctional secretory molecules with trophic, antiapoptotic, anti-inflammatory, antimicrobial and probably immuno-regulatory effects. Since their discovery, accumulating evidence has clarified the potential roles of the REG family in the occurrence, progression and development of a wide range of inflammatory and inflammation-associated diseases of the gastrointestinal (GI) tract. However, significant gaps still exist due to the undefined nature of certain receptors, regulatory signaling pathways and possible interactions among distinct Reg members. In this narrative review, we first describe the structural features, distribution pattern and purported regulatory mechanisms of REG family proteins. Furthermore, we summarize the established and proposed roles of REG proteins in the pathogenesis of various inflammation-associated pathologies of the GI tract and the body as a whole, focusing particularly on carcinogenesis in the ulcerative colitis—colitic cancer sequence and gastric cancer. Finally, the clinical relevance of REG products in the context of diagnosis, treatment and prognostication are also discussed in detail. The current evidence suggests a need to better understanding the versatile roles of Reg family proteins in the pathogenesis of inflammatory-associated diseases, and their broadened future usage as therapeutic targets and prognostic biomarkers is anticipated. 相似文献
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89.
Simulation of the flocculation process using both inorganic and polymer flocculants is very difficult because there are many factors that influence the process. In this study, a model that enables the visual understanding of the qualitative trends of the flocculation system using both inorganic and polymer flocculants is proposed. It is a simplified one-dimensional model that expresses flocculation under various additive manners of the flocculant. Various kinds of thought experiments as well as experimental runs with model flocculants were carried out based on the model; the results demonstrate that the model can express many empirical qualitative trends of flocculation. 相似文献
90.
Tradeoffs between quantization and packet loss in networked control of linear systems 总被引：1，自引：0，他引：1
In this paper, we consider to derive the coarsest memoryless quantizer which can stabilize a single-input discrete-time linear time-invariant system with stochastic packet loss in the sense of stochastic quadratic stability. We show that the upper bound of the coarseness is strictly given by the packet loss probability and the unstable poles of the plants. We furthermore deal with permissible dead-zone width around the origin of the quantizers and time-varying finite quantizers in order to realize control using finite quantization steps. 相似文献