基于MySQL的计划表自动生成方法研究

MySql是一种快速的、功能强大的、价格低廉的网络数据库.针对在计划表生成过程中遇到的效率低、易发生错误的实际问题,在现有的网络办公设备基础上,设计出一组客户程序来实现数据分析、数据上传、项目配置和VBA代码文件自动生成等功能,并描述了其实现过程.经过实践检验,本方法可以有效地解决上述问题,提高工作效率.     

分布式环境下分类知识的挖掘算法研究

计算机及通信网络的快速发展,对数据挖掘算法的分布化提出了要求.介绍分布式数据挖掘的结构,然后重点针对分类知识的挖掘,探讨目前分布式环境下主要的分类挖掘算法.     

氢溴酸-浓硫酸法合成1-溴己烷

以工业废氢溴酸(48%)为原料,在浓硫酸存在下与正己醇反应,制取1-溴己烷.考察了反应条件对产率的影响,比较合适的反应条件为:n(正己醇):n(氢溴酸):n(浓硫酸)=1:1.15:1.38,反应时间3 h,反应温度110～115℃.产率达96.3%.放大及重复实验同样得到了较高的、稳定的产率,说明该方案具有很好的再现性,粗产品经气相色谱分析证明无副产物.     

奥卡西平及其中间体的新合成方法

介绍了一种新的合成奥卡西平(OCBZ)及其中间体的方法:以5H-二苯并[b,f]氮杂卓-5-甲酰氯为原料,通过加成溴化、氨解、水解得到OCBZ,总收率可达62左右,OCBZ的摩尔分数大于99.0。考察了影响氨解反应的因素,优化条件为n(NH3)/n(10,11-二溴-5H-二苯并[b,f]氮杂卓-5-甲酰氯)=5,反应温度约20℃,反应时间约35h,10-溴-5H-二苯并[b,f]氮杂卓-5-甲酰胺收率大于98,摩尔分数大于98.0。结果表明,温度高时氨解反应主要易生成副产物10,11-二溴-5H-二苯并[b,f]氮杂卓。主要产物及副产物的结构均用元素分析和MS进行了确证。该文报道工作的新颖性,已为浙江省科技信息研究院2008年1月8日出具的第200833B210143号《科技查新报告》所证实。该工作已进行1t/a规模的中试,结果为:平均收率约61,产品摩尔分数大于99.1。     

修正二面角散射模型的改进四分量分解

提出了一种面向极化合成孔径雷达数据的改进四分量分解方法.针对极化分解中体散射过高估计问题,改进极化分解使用分布二面角散射模型替代四分量分解原相干偶次散射模型,并引入归一化圆相关系数以实现分解.将改进极化分解运用到奥伯法芬霍芬(Oberpfaffenhofen)地区的实验合成孔径雷达(Experimental Synthetic Aperture Radar,ESAR)的全极化机载L波段数据和北京地区的先进陆地观测卫星L波段相控阵合成孔径雷达(the Phased Array Lband SAR sensor of Advanced Land Observing Satellite,ALOS PALSAR)的全极化星载数据,通过负功率像素、地物散射分量的对比,以及分解结果和光学图像的比对三个方面说明了改进极化分解的有效性.改进极化分解能够有效降低体散射分量,减少负功率像素个数,以及正确获得45°建筑的散射机制.     

宽带高斯型功率谱噪声信号相关特性分析

宽带噪声雷达具有良好的抗干扰和低截获性能.传统的窄带相关函数由于忽略了运动目标的多普勒色散效应而无法准确分析宽带信号的相关特性.本文以宽带噪声调频雷达测量高速目标为研究背景,推导了宽带相关函数均值的解析表达式,并对其进行了仿真验证.在此基础上分析得出,当多普勒色散积较大时宽带相关函数具有双峰特性,并揭示了其产生原因,指出了双峰位置与多普勒色散积及相对带宽之间的关系.为宽带高斯谱噪声雷达的分辨力和检测性能分析以及系统的参数设计提供了理论基础.     

浓缩型和粉末型大豆磷脂对速冻水饺品质的影响

研究浓缩型和粉末型两类大豆磷脂对速冻水饺品质的影响。通过对速冻水饺的冻裂率、煮后破肚率、质构及感官评分进行综合评定,发现分别加入0.2%、0.4%、0.6%、0.8%和1.0%的浓缩大豆磷脂或粉末大豆磷脂均能降低速冻水饺的冻裂率和煮后破肚率,提高速冻水饺的感官评分,增强速冻生饺皮的硬度、弹性、内聚性和咀嚼性等质构指标。尤其添加量为0.4%时,效果最明显,浓缩型和粉末型大豆磷脂均能使速冻水饺的冻裂率降低14%;破肚率分别降低14%和12%;速冻水饺的感官评分分别提高80.5%和73.2%;速冻生饺皮的硬度分别提高79.1%和0.1%;弹性分别增强64.9%和62.3%;内聚性增加37.9%和3.98%;咀嚼性分别提高72.1%和10.9%,且添加0.4%浓缩大豆磷脂对速冻水饺质量提高更大,得到的速冻水饺的质量更好。      

Scatchard-Hildebrand热力学模型在预测PE中有害物质迁移分配系数的应用

为更加准确预测PE塑料中化合物向食品中迁移的分配系数。以PE中抗氧剂为代表,从大量文献中筛选PE中有害迁移物向食品模拟液迁移测试的可靠实验数据,将分配系数实验值F_exp与模型预测分配系数计算值F_sim对比分析,并对Scatchard-Hildebrand热力学模型进行实验校正,研究了温度（T）、迁移物分子量（M）和醇-水分配系数（log P）以及模拟液极性（ln Ps）与修正系数Ks(Ks=ln(F_sim/F_exp)的关系。结果表明除个别化合物因其分子结构特殊外,PE中化学物向脂肪类食品模拟液中迁移分配系数预测模型的修正系数Ks与M、log P、ln Ps均呈显著的线性相关性,得到修正后的Scatchard-Hildebrand热力学模型F’_sim=exp(V迁移物/RT·[φ_模拟液²(δ_迁移物-δ_模拟液)²-φ_聚合物²(δ_迁移物-δ_聚合物)²]-7.289-0.021M-1.317ln Ps+0.901log P),其在一定程度上能够预测PE中有害物质向脂肪类食品模拟物中迁移的分配系数。      

Circ_0011129 Encapsulated by the Small Extracellular Vesicles Derived from Human Stem Cells Ameliorate Skin Photoaging

Photoaging is not only the main cause of skin aging caused by exogenous factors, it is also related to a variety of skin diseases and even malignant tumors. Excessive and repeated exposure to ultraviolet radiation, especially UVA induces oxidative stress, DNA damage, inflammation, and collagen and elastin degeneration, ultimately leads to skin photoaging, manifested by skin redness, coarse wrinkles, and pigmentation even skin cancer. There has been a large demand of effective prevention and medications but approaches in the current management of photoaging are very limited. In the previous study, we found that a non-coding circular RNA circ_0011129 acts as a miR-6732-5p adsorption sponge to inhibit the reduction of type I collagen and the denaturation and accumulation of elastin in UVA-induced HDF cells photoaging model. However, in vivo instability and efficient delivery to the target cell of circRNA is a major challenge for its clinical application. Therefore, improving its stability and delivery efficiency are desired. In this study, we proposed a strategy of delivering circ_0011129 with small extracellular vesicles (sEVs) from human adipose-derived stem cells (hADSCs) to intervene in the photoaging process. The results showed that sEVs from hADSCs in 3D bioreactor culture (3D-sEVs) can prevent photoaging. Consequently, by overexpressing circ_0011129 in hADSCs, we successfully loaded it into 3D-sEVs (3D-circ-sEVs) and its protective effect was better. Our studies provide a novel approach to preventing skin photoaging, which has important clinical significance and application value for the development of non-coding RNA drugs to treat skin photoaging. We first screened out hADSCs-derived sEVs with excellent anti-oxidant effects. We then compared the sEVs collected from traditional 2D culture with 3D bioreactor culture. By miRNA-seq and GEO data analysis, we found that miRNAs in 3D-sEVs were enriched in cell activities related to apoptosis, cellular senescence, and inflammation. Subsequently, we prepared circ_0011129-loaded 3D-sEVs (3D-circ-sEVs) by overexpressing it in hADSCs for the treatment of photoaging in vitro. We proved that 3D-circ-sEVs can interfere with the process of cell photoaging and protect cells from UVA radiation damage, as well as in a H2O2-induced oxidative stress model.