Phonological recoding in reading for meaning by adults and children.

Phonological recoding in reading has been studied by requiring adults or children to judge whether printed sentences are correct or not. When some sentences are orthographically unacceptable but phonologically acceptable (e.g., The girl through the ball), both children and adults make abnormally many false positives with such sentences. It is unclear whether the phonological recoding that produces this effect is attributable to assembled (nonlexical) or addressed (lexical) phonology. Two types of phonologically acceptable but orthographically unacceptable sentences were devised: Those in which the crucial item ("through" in the above example) was an irregular word (so that its phonology could only be obtained lexically), and those in which the crucial item was a homophonic nonword (so that its phonology could only be obtained by assembled phonology). Both types of sentence produced significantly high false-positive rates for adult readers and children, indicating the use of assembled and addressed phonology during sentence reading. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Building the essential resources for Finnish: the Turku Dependency Treebank

In this paper, we present the final version of a publicly available treebank of Finnish, the Turku Dependency Treebank. The treebank contains 204,399 tokens (15,126 sentences) from 10 different text sources and has been manually annotated in a Finnish-specific version of the well-known Stanford Dependency scheme. The morphological analyses of the treebank have been assigned using a novel machine learning method to disambiguate readings given by an existing tool. As the second main contribution, we present the first open source Finnish dependency parser, trained on the newly introduced treebank. The parser achieves a labeled attachment score of 81 %. The treebank data as well as the parsing pipeline are available under an open license at http://bionlp.utu.fi/.     

Gastric Serotonin Biosynthesis and Its Functional Role in L-Arginine-Induced Gastric Proton Secretion

Among mammals, serotonin is predominantly found in the gastrointestinal tract, where it has been shown to participate in pathway-regulating satiation. For the stomach, vascular serotonin release induced by gastric distension is thought to chiefly contribute to satiation after food intake. However, little information is available on the capability of gastric cells to synthesize, release and respond to serotonin by functional changes of mechanisms regulating gastric acid secretion. We investigated whether human gastric cells are capable of serotonin synthesis and release. First, HGT-1 cells, derived from a human adenocarcinoma of the stomach, and human stomach specimens were immunostained positive for serotonin. In HGT-1 cells, incubation with the tryptophan hydroxylase inhibitor p-chlorophenylalanine reduced the mean serotonin-induced fluorescence signal intensity by 27%. Serotonin release of 147 ± 18%, compared to control HGT-1 cells (set to 100%) was demonstrated after treatment with 30 mM of the satiating amino acid L-Arg. Granisetron, a 5-HT3 receptor antagonist, reduced this L-Arg-induced serotonin release, as well as L-Arg-induced proton secretion. Similarly to the in vitro experiment, human antrum samples released serotonin upon incubation with 10 mM L-Arg. Overall, our data suggest that human parietal cells in culture, as well as from the gastric antrum, synthesize serotonin and release it after treatment with L-Arg via an HTR3-related mechanism. Moreover, we suggest not only gastric distension but also gastric acid secretion to result in peripheral serotonin release.