An evolutionary approach to pattern-based time series segmentation

Time series data, due to their numerical and continuous nature, are difficult to process, analyze, and mine. However, these tasks become easier when the data can be transformed into meaningful symbols. Most recent works on time series only address how to identify a given pattern from a time series and do not consider the problem of identifying a suitable set of time points for segmenting the time series in accordance with a given set of pattern templates (e.g., a set of technical patterns for stock analysis). However, the use of fixed-length segmentation is an oversimplified approach to this problem; hence, a dynamic approach (with high controllability) is preferable so that the time series can be segmented flexibly and effectively according to the needs of the users and the applications. In view of the fact that this segmentation problem is an optimization problem and evolutionary computation is an appropriate tool to solve it, we propose an evolutionary time series segmentation algorithm. This approach allows a sizeable set of pattern templates to be generated for mining or query. In addition, defining similarity between time series (or time series segments) is of fundamental importance in fitness computation. By identifying the perceptually important points directly from the time domain, time series segments and templates of different lengths can be compared and intuitive pattern matching can be carried out in an effective and efficient manner. Encouraging experimental results are reported from tests that segment both artificial time series generated from the combinations of pattern templates and the time series of selected Hong Kong stocks.     

Effect of irradiation on the impact and seismic response of a spent fuel storage and transport cask

The spent fuel storage and transport cask must withstand various accident conditions such as fire, free drop and puncture in accordance with the requirement of the IAEA and domestic regulations. The spent fuel storage and transport cask should maintain the structural safety not to release radioactive material in any condition. And also the effects of the irradiation should be considered because the spent fuels stored in the cask for a long time and be possible to change the mechanical properties of the cask.In this study, the changed mechanical properties of the cask after irradiation for the 30 years storage periods are assumed and applied to the impact analysis using ABAQUS/Explicit code and seismic analysis using ANSYS code. The stress intensity on each part of the cask is calculated and the effects of irradiation are studied and structural integrity of the package is evaluated.     

Decreased Expression of Plakophilin-2 and αT-Catenin in Arrhythmogenic Right Ventricular Cardiomyopathy: Potential Markers for Diagnosis

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disease of the heart muscle. Clinical challenges remain, however, in identifying patients with ARVC in the early or concealed stages with subtle clinical manifestations. Therefore, we wanted to identify potential targets by immunohistochemical (IHC) analysis in comparison with controls. Pathogenic mutations were identified in 11 of 37 autopsied patients with ARVC. As observed from IHC analysis of the RV, expression of αT-catenin and plakophilin-2 is significantly decreased in autopsied patients with ARVC as compared to controls, and the decreased expression is consistent in patients with and without pathogenic mutations. Furthermore, ARVC specimens demonstrated a reduced localization of αT-catenin, desmocollin-2, desmoglein-2, desmoplakin, and plakophilin-2 on intercalated discs. These findings have been validated by comparing RV specimens obtained via endomyocardial biopsy between patients with ARVC and those without. The pathogenic mutation was present in 3 of 5 clinical patients with ARVC. In HL-1 myocytes, siRNA was used to knockdown CTNNA3, and western blotting analysis demonstrated that the decline in αT-catenin expression was accompanied by a significant decline in the expression of plakophilin-2. The aforementioned effect was directed towards protein degradation rather than mRNA stability. Plakophilin-2 expression decreases concurrently with the decline in CTNNA3 expression. Therefore, the expression of αT-catenin and plakophilin-2 could be potential surrogates for the diagnosis of ARVC.     

MicroRNAs as Potential Biomarkers in the Differential Diagnosis of Lipomatous Tumors and Their Mimics

Adipocytic tumors are the most common subtype of soft tissue tumors. In current clinical practice, distinguishing benign lipomas from well-differentiated liposarcomas (WDLPS), as well as dedifferentiated liposarcomas (DDLPS) from their morphologic mimics, remains a significant diagnostic challenge. This is especially so when examining small biopsy samples and without the aid of additional ancillary tests. Recognizing the important role that microRNAs (miRNAs) play in tumorigenesis and their potential utility in tumor classification, we analyzed routine clinical tissue samples of benign and malignant lipomatous tumors, as well as other sarcoma mimics, to identify distinguishing miRNA-based signatures that can aid in the differential diagnosis of these entities. We discovered a 6-miRNA signature that separated lipomas from WDLPS with high confidence (AUC of 0.963), as well as a separate 6-miRNA signature that distinguished DDLPS from their more aggressive histologic mimics (AUC of 0.740). Functional enrichment analysis unveiled possible mechanistic involvement of these predictive miRNAs in adipocytic cancer-related biological processes and pathways such as PI3K/AKT/mTOR and MAPK signaling, further supporting the relevance of these miRNAs as biomarkers for adipocytic tumors. Our results demonstrate that miRNA expression profiling may potentially be used as an adjunctive tool for the diagnosis of benign and malignant adipocytic tumors. Further validation studies are warranted.     

The pH effect for rare earth metals Nd, Pr and Y in aqueous solution dissolved Mg, Zn and Al

The pH variations of Mg, Zn and Al solutions to which had been added the rare earth metals Nd, Pr and Y were observed in 3.5 wt.% NaCl with respect to high energy mechanical ball milling effects. Mg was directly dissolved and exhibited a pH value of 10.5. On the other hand, Zn and Al needed to be saturated for a certain amount of time. The addition of rare earth metals played a role in increasing the pH with low reduction potentials. Additionally, mechanical ball milling provided high energy to Mg + x wt.% Zn + 0.5 wt.% Nd mixture by fracturing fragmentation of metals, which led to an increase in the pH when the mixture was immersed in 3.5 wt.% NaCl. The addition of Zn to Mg + 0.5 wt.% Nd caused a higher pH than when Mg + 0.5 wt.% Nd alone was added.     

Minimum-loss strategy for three-phase PWM rectifier

In this paper, the conduction and switching losses of a voltage-fed three-phase pulsewidth modulation (PWM) rectifier are analyzed for various PWM schemes. On the basis of this result, a novel PWM strategy which minimizes the loss of a three-phase PWM rectifier is developed. This minimization result is derived from the following two factors: (1) less switching frequency ratio; and (2) the absence of switching in the vicinity of peak input current. As a result, it is anticipated that the switching loss of the rectifier is reduced by 46%, compared with continuous space-vector PWM rectifiers, and 20% compared with conventional discontinuous space-vector PWM rectifiers. Moreover, the proposed PWM scheme can produce the highest available output voltage because it is based on the concept of the voltage space vector. The effectiveness of the proposed PWM strategy is verified by experiments     

在双镶嵌铜互联中O.13微米器件生成用的基于PVD和ALD阻挡层的先进技术

1. Introduction The requirement of minimal bottom coverageand thick sidewall coverage for PVD-based films forlow via resistance and improved stress migration isnot easy to achieve with traditional depositionmethods. Modern I-PVD techniques give high bot-tom coverage, due to the ionized component of thedeposition flux. Sidewall coverage tends to be low,which is mainly due to off-normal deposition fluxand a less than unity sticking coefficient.     

Improving the electrical and mechanical behavior of electrically conductive paint by partial replacement of silver by carbon black

Partial replacement of silver particles by carbon black (low cost) in electrically conductive paint was found to decrease the electrical resistivity and increase the scratch resistance of the resulting thick film, which is for use in electrical interconnections. An effective carbon black content is 0.055 of the total filler volume. By using a total solid volume fraction of 0.1969 and a silane-propanol (1:1 by weight) solution as the vehicle, a paint that gives a thick film with resistivity 2 × 10⁻³ Ω·cm has been attained.     

Growth of InGaN HBTs by MOCVD

The design and growth of GaN/InGaN heterojunction bipolar transistors (HBTs) by metalorganic chemical vapor deposition (MOCVD) are studied. Atomic-force microscopy (AFM) images of p⁺InGaN base layers (∼100 nm) deposited under various growth conditions indicate that the optimal growth temperature is limited to the range between 810 and 830°C due to a trade-off between surface roughness and indium incorporation. At these temperatures, the growth pressure must be kept above 300 Torr in order to keep surface pit density under control. An InGaN graded-composition emitter is adopted in order to reduce the number of V-shaped defects, which appear at the interface between GaN emitter and InGaN base and render an abrupt emitter-base heterojunction nearly impossible. However, the device performance is severely limited by the high p-type base contact resistance due to surface etching damage, which resulted from the emitter mesa etch.