Health resort treatment of eye diseases caused by ischemia]

The authors discuss the results of ophthalmodynamometric tests used for the assessment of cerebro-retinal vessels reactivity following carbon dioxide baths and "peat collars". An analysis of systemic and local blood pressure in the ophthalmic artery measured with Weigelin and Lobstein technique enables to assess changes in blood pressures following a/m balneologic procedures. It was found that blood pressure does not change parallelly due to the mechanism of cerebral autoregulation. Transient decrease in blood pressure in the ophthalmic artery is produced by the dilatation of the internal carotid artery indicating a potent vasodilating action of carbon dioxide.     

Where does the end begin? Problems in musico-cognitive modeling

Research with computer systems and musical grammars into improvisation as found in the tabla drumming system of North India has indicated that certain musical sentences comprise (a) variable prefixes, and (b) fixed suffixes (or cadences) identical with those of their original rhythmic themes. It was assumed that the cadence functioned as a kind of target in linear musical space, and yet experiments showed that defining what exactly constituted the cadence was problematic. This paper addresses the problem of the status of cadential patterns, and demonstrates the need for a better understanding and formalization of ambiguity in musico-cognitive processing. It would appear from the discussion that the cadence is not a discrete unit in itself, but just part of an ever-present underlying framework comprising the entire original rhythmic theme. Improvisations (variations), it is suggested, merely break away from and rejoin this framework at important structural points. This endorses the theory of simultaneity. However, the general cognitive implications are still unclear, and further research is required to explore musical ambiguity and the interaction of musical, linguistic, and spatio-motor grammars.     

Microwave surface resistance of epitaxial YBa2Cu3O7 thin films at 18.7 GHz measured by a dielectric resonator technique

We used a dielectric resonator technique for highly sensitive measurements of the temperature dependence of the microwave surface resistanceR _s of 1×1 cm² superconducting films at 18.7 GHz. It consists of a sapphire disc positioned on the film under investigation within a copper cavity which is acting as a radiation shield. In the TE₀₁ oscillation mode the highly reproducible quality factor of about 10⁵ results in a sensitivity of ±50 forR _s measurements. The temperature dependence ofR _s can be measured up to values as high as 1 . We have investigated several YBa₂Cu₃O₇ thin films prepared by high oxygen pressure d.c. sputtering on LaAlO₃ and NdGaO₃. Our best films exhibit a pronounced nonlinear behavior of the d.c. resistivity(T) with(300K)/(100K) values of about 3.7. Those films show, besides the initial fall-off just belowT _c , a further strong decrease ofR _s at low temperatures. This was observed both at 18.7 GHz and 87 GHz, as measured by a conventional cavity end plate replacement technique. ForTT_c/2 these films exhibit an exp (–T _c/T) dependence ofR _s with-values around 0.4. These observations may be explained by a superconducting energy gap with 2/kT _c0.8 for charge carriers localized in the CuO chains for YBa₂Cu₃O₇.     

The quantifier structure of sentences that characterize nondeterministic time complexity

For every nondeterministic Turing machineM of time complexityT(n), there is a second-order sentence of a very restricted form, whose set of finite models encodes the set of strings recognized byM. Specifically, has a relational symbol which is interpreted as addition restricted to finite segments of the natural numbers, and a prefix consisting of existentially quantified unary second-order variables followed by a universal-existential first-order part. Here, every input stringx is encoded by a model of sizeT(|x|). Using a closely related encoding of strings as models where the size of the model is the length of the string, a consequence is that ifT(n)=n ^d, then there is a sentence with a similar prefix but whose second-order variables ared-ary and whose finite models encode the strings accepted byM. Potential applications to low-level complexity are discussed.     

Curing characteristics of a composite matrix

The account describes investigations into the variations of specific volume and viscosity of a typical high-performance epoxy resin during various time-temperature cycles. The work was undertaken primarily to provide additional background information relating to the nature and causes of fibre kinking which has been observed in laminates comprising epoxy-carbon composite. The investigation has quantified certain characteristics of the resin which are presumed to be major contributory factors in the occurrence of fibre kinking. It is concluded that a simple solution to the general problem cannot be identified, although some possibilities are discussed for individual cases.     

The use of the aquarium fishes Danio rerio and Poecilia reticulata as highly sensitive species for testing the carcinogenicity of chemical compounds

Aquarium fishes Danio rerio and Poecilia reticulata are recommended as test-objects for testing carcinogenic chemical agents. 30 compounds were tested for their action on these objects. The analysis of the incidence of induced tumors, period of their appearance and Iball index shows high sensitivity of the aquarium fishes to the carcinogenic action. Data are presented on the dynamics of experimental carcinogenesis, morphology of induced tumours, as well as on modifications of carcinogenesis (the role of environmental temperature, age, dose, exposition, etc.). Advantages and limitations of the "fish model" are compared with those found in the experiments carried on mammals.     

On parallel unification for Prolog

Parallel unification algorithms are not nearly so numerous or well-developed as sequential ones. In order to estimate the improvement in efficiency which may be expected, we define and discuss an objective measure of the effect of parallelism on a sequential algorithm. This measure, known as thepotential parallel factor (PPF), is applied to parallel versions of the unification algorithms of Yasuura and Jaffar. The PPFs for these algorithms are measured on a variety of running Prolog programs to estimate what increase in speed may be expected in a Prolog environment from the use of parallelism. Other potential uses of parallelism may be evaluated by different applications of our general methods and techniques.     

Fluctuating NMDA Receptor Subunit Levels in Perirhinal Cortex Relate to Their Dynamic Roles in Object Memory Destabilization and Reconsolidation

Reminder cues can destabilize consolidated memories, rendering them modifiable before they return to a stable state through the process of reconsolidation. Older and stronger memories resist this process and require the presentation of reminders along with salient novel information in order to destabilize. Previously, we demonstrated in rats that novelty-induced object memory destabilization requires acetylcholine (ACh) activity at M₁ muscarinic receptors. Other research predominantly has focused on glutamate, which modulates fear memory destabilization and reconsolidation through GluN2B- and GluN2A-containing NMDARs, respectively. In the current study, we demonstrate the same dissociable roles of GluN2B- and N2A-containing NMDARs in perirhinal cortex (PRh) for object memory destabilization and reconsolidation when boundary conditions are absent. However, neither GluN2 receptor subtype was required for novelty-induced destabilization of remote, resistant memories. Furthermore, GluN2B and GluN2A subunit proteins were upregulated selectively in PRh 24 h after learning, but returned to baseline by 48 h, suggesting that NMDARs, unlike muscarinic receptors, have only a temporary role in object memory destabilization. Indeed, activation of M₁ receptors in PRh at the time of reactivation effectively destabilized remote memories despite inhibition of GluN2B-containing NMDARs. These findings suggest that cholinergic activity at M₁ receptors overrides boundary conditions to destabilize resistant memories when other established mechanisms are insufficient.     

Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly

Lipoyl synthase (LIAS) is an iron–sulfur cluster protein and a member of the radical S-adenosylmethionine (SAM) superfamily that catalyzes the final step of lipoic acid biosynthesis. The enzyme contains two [4Fe–4S] centers (reducing and auxiliary clusters) that promote radical formation and sulfur transfer, respectively. Most information concerning LIAS and its mechanism has been determined from prokaryotic enzymes. Herein, we detail the expression, isolation, and characterization of human LIAS, its reactivity, and evaluation of natural iron–sulfur (Fe–S) cluster reconstitution mechanisms. Cluster donation by a number of possible cluster donor proteins and heterodimeric complexes has been evaluated. [2Fe–2S]-cluster-bound forms of human ISCU and ISCA2 were found capable of reconstituting human LIAS, such that complete product turnover was enabled for LIAS, as monitored via a liquid chromatography–mass spectrometry (LC–MS) assay. Electron paramagnetic resonance (EPR) studies of native LIAS and substituted derivatives that lacked the ability to bind one or the other of LIAS’s two [4Fe–4S] clusters revealed a likely order of cluster addition, with the auxiliary cluster preceding the reducing [4Fe–4S] center. These results detail the trafficking of Fe–S clusters in human cells and highlight differences with respect to bacterial LIAS analogs. Likely in vivo Fe–S cluster donors to LIAS are identified, with possible connections to human disease states, and a mechanistic ordering of [4Fe–4S] cluster reconstitution is evident.