Preventing risky driving: A novel and efficient brief intervention focusing on acknowledgement of personal risk factors

Impulsive personality is an important predictor of risky driving. Acknowledging their impulsive tendencies may help novice drivers to drive more safely. The aim of this study was to evaluate the efficacy of a novel brief intervention targeting novice drivers’ risky behavior in traffic, taking into account potential moderator effects. Driving school students (n = 1866) were divided into an intervention group and a control group. The intervention consisted of a lecture and group work (1.5 h). Subjects’ traffic offenses and crashes were monitored during the following year using police and traffic insurance fund databases. The groups were similar in their baseline characteristics. The intervention group had half as many speeding violations in the year following the intervention compared with the controls. The proportion of speeders was significantly lower in the intervention group compared with the control group in subgroups of subjects with medium cognitive abilities and low or medium BIS-11 impulsiveness levels. In alpha_2A-adrenoceptor gene (ADRA2A) G allele carriers, general traffic risk and speeding decreased in response to the intervention, unlike in subjects with the CC genotype. It is concluded that brief interventions that are integrated into the driving education program and focus on personal psychological risk factors may be effective for improving traffic safety.     

Early Stage CAD-Compliant Energy Performance Assessment Method

A simple calculator for early stage energy performance assessment in residential buildings was developed and partially validated in this study. The calculator is based on the correlation of heat loss and energy need for heating and has fixed internal heat gains as intended for compliance assessment. With the calculator, the effect of any parameter implemented can be immediately seen on delivered and primary energy. Because of simple equations, it is suitable for implementation into CAD （computer aided design） design tools including basic BIM （building information modeling） data. Results showed that the accuracy of the correlation for the cases with practical relevance was not worse than 14% of the energy need of space heating. This applies for passive house insulation level; for less insulated building envelopes, the deviations were smaller. This 14% equals to only 3 kWh/（m2.a）, i.e., the percentage difference in the total delivered and primary energy was much lower because of other components in the energy balance. The deviations determined were implemented in the calculator as safety margin. Results prove that simple energy performance assessment based on specific heat loss coefficient is well justified for early stage energy analyses as well as for compliance assessment implemented in Estonian regulation.     

Boundary of the volume swept by a free-form solid in screw motion

The swept volume of a moving solid is a powerful computational and visualization concept. It provides an excellent aid for path and accessibility planning in robotics and for simulating various manufacturing operations. It has proven difficult to evaluate the boundary of the volume swept by a solid bounded by trimmed parametric surfaces undergoing an arbitrary analytic motion. Hence, prior solutions use one or several of the following simplifications: (1) approximate the volume by the union of a finite set of solid instances sampled along the motion; (2) approximate the curved solid by a polyhedron; and (3) approximate the motion by a sequence of simpler motions. The approach proposed here is based on the third type of simplification: it uses a polyscrew (continuous, piecewise-helical) approximation of the motion. This approach leads to a simple algorithm that generates candidate faces, computes the two-cells of their arrangement, and uses a new point-in-sweep test to select the correct cells whose union forms the boundary of the swept volume.     

Summer thermal comfort: compliance assessment and overheating prevention in new apartment buildings in Estonia

This study analyses which building parameters contribute the most to overheating in dwellings and which properties will make a room ‘critical’, to be chosen for compliance assessment procedure through temperature simulation, as required in Estonia for new residential buildings. Indoor temperature measurements, conducted in 18 apartments from 16 apartment buildings, show clear evidence of overheating. Compliance assessment of 25 new buildings were conducted using IDA-ICE software. The analysed sample consisted of typical multi-storeyed buildings with mainly massive concrete structures. From the simulated buildings, 68% did not meet the requirements, showing that this relatively new building code requirement was not fully established in practice. Results of the analysis indicate that the requirement in apartment buildings is achievable without cooling, if passive measures are properly applied. Recommendations are given to designers, as well as policy-makers, to improve the situation in the residential building sector.     

Depth-Buffering Display Techniques for Constructive Solid Geometry

Solid modelers based on constructive solid geometry (CSG) typically generate shaded displays directly from CSG by using ray-casting techniques, which do not require informatin on the faces, edges, and vertices that bound a solid. This article describes an alternative-a simple new algorithm based on a depth-buffering or z-buffering approach. The z-buffer display algorithm operates directly on CSG, does not require explicit boundary data, and is easier to implement than ray casting. Ray-casting and z-beffering algorithms have comparable performances, but z-buffering is often faster for objects with complex surfaces, because it avoids expensive curve/surface intersection calculations. Because of their simplicity, depth-buffering algorithms for CSG are well-suited to hardware implementations, and may lead to machines simpler than those now being built for ray casting.     

Recent Development in NKT-Based Immunotherapy of Glioblastoma: From Bench to Bedside

Glioblastoma multiforme (GBM) is an aggressive and dismal disease with a median overall survival of around 15 months and a 5-year survival rate of 7.2%. Owing to genetic mutations, drug resistance, disruption to the blood–brain barrier (BBB)/blood–brain tumor barrier (BBTB), and the complexity of the immunosuppressive environment, the therapeutic approaches to GBM represent still major challenges. Conventional therapies, including surgery, radiotherapy, and standard chemotherapy with temozolomide, have not resulted in satisfactory improvements in the overall survival of GBM patients. Among cancer immunotherapeutic approaches, we propose that adjuvant NKT immunotherapy with invariant NKT (iNKT) and cytokine-induced killer (CIK) cells may improve the clinical scenario of this devastating disease. Considering this, herein, we discuss the current strategies of NKT therapy for GBM based primarily on in vitro/in vivo experiments, clinical trials, and the combinatorial approaches with future therapeutic potential.     

A semantic grid infrastructure enabling integrated access and analysis of multilevel biomedical data in support of postgenomic clinical trials on cancer.

This paper reports on original results of the Advancing Clinico-Genomic Trials on Cancer integrated project focusing on the design and development of a European biomedical grid infrastructure in support of multicentric, postgenomic clinical trials (CTs) on cancer. Postgenomic CTs use multilevel clinical and genomic data and advanced computational analysis and visualization tools to test hypothesis in trying to identify the molecular reasons for a disease and the stratification of patients in terms of treatment. This paper provides a presentation of the needs of users involved in postgenomic CTs, and presents such needs in the form of scenarios, which drive the requirements engineering phase of the project. Subsequently, the initial architecture specified by the project is presented, and its services are classified and discussed. A key set of such services are those used for wrapping heterogeneous clinical trial management systems and other public biological databases. Also, the main technological challenge, i.e. the design and development of semantically rich grid services is discussed. In achieving such an objective, extensive use of ontologies and metadata are required. The Master Ontology on Cancer, developed by the project, is presented, and our approach to develop the required metadata registries, which provide semantically rich information about available data and computational services, is provided. Finally, a short discussion of the work lying ahead is included.     

External shading optimal control macros for 1- and 2-piece automated blinds in European climates

Dynamic external shading is considered an effective measure for improving energy performance and decreasing cooling loads. Optimal control principle is needed to minimize energy use and maximize occupants’ satisfaction. We developed and described in detail optimal control macros in software IDA ICE 4.5 and simulated office building energy performances with varying facade solutions and climates over Europe. Primary energy savings between 1 and 32 kWh/m² were reached. Shading control to avoid glare during office hours and overheating outside work time was recommended in Tallinn and Paris. In addition shading adjustment according to room temperature during work time was necessary in Athens to minimize energy use. Also suntracking could be used in Tallinn and Paris, but PI-controllers for slat angle control were needed in Athens. Cooling load comparison of internal and external shading showed significant reduction in space cooling capacities ranging between 40% and 70%, whereas design date selection influenced cooling system design considerably besides facade solutions and orientations. Developed control macros are proposed for testing in other studies in order to find optimal control principles satisfying office workers which then could be generally implemented in design guidelines and manuals.