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排序方式: 共有459条查询结果,搜索用时 15 毫秒
21.
Myriam Janeth Salazar-Terreros Jean-Paul Vernot 《International journal of molecular sciences》2022,23(13)
Cellular senescence is recognized as a dynamic process in which cells evolve and adapt in a context dependent manner; consequently, senescent cells can exert both beneficial and deleterious effects on their surroundings. Specifically, senescent mesenchymal stromal cells (MSC) in the bone marrow (BM) have been linked to the generation of a supporting microenvironment that enhances malignant cell survival. However, the study of MSC’s senescence role in leukemia development has been straitened not only by the availability of suitable models that faithfully reflect the structural complexity and biological diversity of the events triggered in the BM, but also by the lack of a universal, standardized method to measure senescence. Despite these constraints, two- and three dimensional in vitro models have been continuously improved in terms of cell culture techniques, support materials and analysis methods; in addition, research on animal models tends to focus on the development of techniques that allow tracking leukemic and senescent cells in the living organism, as well as to modify the available mice strains to generate individuals that mimic human BM characteristics. Here, we present the main advances in leukemic niche modeling, discussing advantages and limitations of the different systems, focusing on the contribution of senescent MSC to leukemia progression. 相似文献
22.
Céline Druart Evelyne M. Dewulf Patrice D. Cani Audrey M. Neyrinck Jean-Paul Thissen Nathalie M. Delzenne 《Lipids》2014,49(4):397-402
The aim of this human study was to assess the influence of prebiotic-induced gut microbiota modulation on PUFA-derived bacterial metabolites production. Therefore, we analyzed the circulating fatty acid profile including CLA/CLnA in obese women treated during 3 months with inulin-type fructan prebiotics. In these patients, we had already determined gut microbiota composition by phylogenetic microarray and qPCR analysis of 16S rDNA. Some PUFA-derived bacterial metabolites were detected in the serum of obese patients. Despite the prebiotic-induced modulation of gut microbiota, including changes in CLA/CLnA-producing bacteria, the treatment did not impact significantly on the circulating level of these metabolites. However, some PUFA-derived bacterial metabolites were positively correlated with specific fecal bacteria (Bifidobacterium spp., Eubacterium ventriosum and Lactobacillus spp.) and inversely correlated with serum cholesterol (total, LDL, HDL). These correlations suggest a potential beneficial effect of some of these metabolites but this remains to be confirmed by further investigation. 相似文献
23.
Rabeh Slimani Nacer Zazi Jean-Paul Chopart 《Protection of Metals and Physical Chemistry of Surfaces》2016,52(1):111-118
In this work a special regard is given to the morphology of the nickel deposited layers, onto AA1370 aluminum section and central longitudinal surfaces, with and without a weak magnetic field oriented in parallel and perpendicular to the coated surface in modified Watt bath. The obtained results show the formation of honeycomb structure nickel deposits for samples treated with weak parallel oriented field under approximately 0.3 A/cm2, and partial dendritic structure nickel deposit for samples treated with weak perpendicular oriented magnetic field, the perimeter deposits with and without magnetic field is different to the deposits in the remain surface. We attributed the defect of nickel deposits on the surfaces with and without magnetic field to the distribution of the intermetallics particles and we attributed the honeycomb structure to the escapement of hydrogen and oxygen. 相似文献
24.
Taleb Samia Dokhan Nahed Zazi Nacer Chopart Jean-Paul 《Protection of Metals and Physical Chemistry of Surfaces》2019,55(4):781-788
Protection of Metals and Physical Chemistry of Surfaces - In this work the effect of the permanent weak magnetic field on the electrodeposited ZnO nanostructured film on the ITO substrate... 相似文献
25.
Laura Grech Jean-Paul Ebejer Oriana Mazzitelli Kevin Schembri Joseph Borg Elisa Seria 《International journal of molecular sciences》2022,23(1)
Circulating bone marrow mesenchymal progenitors (BMMPs) are known to be potent antigen-presenting cells that migrate to damaged tissue to secrete cytokines and growth factors. An altered or dysregulated inflammatory cascade leads to a poor healing outcome. A skin model developed in our previous study was used to observe the immuno-modulatory properties of circulating BMMP cells in inflammatory chronic wounds in a scenario of low skin perfusion. BMMPs were analysed exclusively and in conjunction with recombinant tumour necrosis factor alpha (TNFα) and recombinant hepatocyte growth factor (HGF) supplementation. We analysed the expression levels of interleukin-8 (IL-8) and ecto-5′-nucleotidase (CD73), together with protein levels for IL-8, stem cell factor (SCF), and fibroblast growth factor 1 (FGF-1). The successfully isolated BMMPs were positive for both hemopoietic and mesenchymal markers and showed the ability to differentiate into adipocytes, chondrocytes, and osteocytes. Significant differences were found in IL-8 and CD73 expressions and IL-8 and SCF concentrations, for all conditions studied over the three time points taken into consideration. Our data suggests that BMMPs may modulate the inflammatory response by regulating IL-8 and CD73 and influencing IL-8 and SCF protein secretions. In conclusion, we suggest that BMMPs play a role in wound repair and that their induced application might be suitable for scenarios with a low skin perfusion. 相似文献
26.
Claire Mangeney Zhengran Qin Si Amar Dahoumane Alain Adenier Frédéric Herbst Jean-Paul Boudou Jean Pinson Mohamed M. Chehimi 《Diamond and Related Materials》2008,17(11):1881-1887
We report a novel and very handful strategy for the functionalization of diamond nanoparticles (NDs), based on the ultrasound-assisted grafting of aryl groups from the electroless reduction of diazonium salts. For this study, 4-nitrobenzenediazonium salt was used as a model molecule and the reaction was investigated in neutral and acidic aqueous media. Spectroscopic evidence for the successful attachment of aryl groups to nanodiamonds (NDs) was given by IR and XPS which clearly detect characteristic NO2 peaks. Moreover, the absence of any peaks from the +N≡N group in the IR spectra is a clear indication of the chemical reduction of the parent diazonium salt at the surface of NDs. This spontaneous chemical modification of NDs by aryl diazonium salts was confined to the surface of the ND particles; indeed, XRD measurements have shown that the crystalline structure of the bulk of the particles was unaffected. It opens up new possibilities towards the control of the surface chemical composition of NDs using simple protocols operated in very soft conditions, i.e. in water at room temperature. It shows conclusively that the chemistry toolbox of experts interested in nanodiamonds should contain aryl diazonium salts, given their versatility in forming active platforms. 相似文献
27.
Fouad Al Katrib Gerard Chambat Jean-Paul Joseleau 《Journal of the science of food and agriculture》1988,43(4):309-317
Enzymic saccharification of wheat straw in the absence of any pretreatment was only about 20 %. Acid hydrolysis did not improve the overall cellulose enzymic breakdown, nor did pretreatment by flash autohydrolysis under pressure or sodium chlorite delignification. When wheat straw was treated with N-methyl-morpholine-N-oxide (MMNO) at J20°C for 20–30 min, this treatment and subsequent enzymic hydrolysis produced carbohydrate conversion of 73%. Similar results could be obtained by treating straw with 0·1 M sodium hydroxide. When MMNO treatment was combined with any other pretreatment, the saccharification yield was greatly enhanced. Nearly quantitative conversion was obtained by swelling straw in 0·1 M sodium hydroxide followed by MMNO treatment. The results show that lignin content of plant material does not represent the limiting factor to enzymic saccharification. 相似文献
28.
Abstract The autochrome was the first successful commercial colour process. It was invented by Louis and Auguste Lumiere at the tum of the century, patented in 1903 and produced until the 1950s on a sheet film called ‘Filmcolor’. Many articles were published between 1903 when the autochrome process was unveiled to the public, and 1935 when the decline of the screen process began and the first colour films with chromogenic development appeared. There are detailed deseriptions of the plate's range of use, its characteristies and processing, but these publications are very sketchy as to the nature of the components. The most detailed documents, on which this article is based, are the ‘report on the titles and work of Louis Lumiere’ published in 1918, the factory notebooks written by Louis Lumiere or M. Perrigot,1 and the archives of the Lumiere firm, which are now scattered in various locations. 相似文献
29.
Yousef Ghorbani Megan BeckerAubrey Mainza Jean-Paul FranzidisJochen Petersen 《Minerals Engineering》2011,24(11):1172-1184
The application of heap leach technology to recovery of economically important metals, notably copper, gold, silver, and uranium, is wide-spread in the mining industry. Unique to heap leaching is the relatively coarse particle size, typically 12-25 mm top size for crushed and agglomerated ores and larger for run-of-mine dump leaching operations. Leaching from such large particles is commonly assumed to follow shrinking core type behaviour, although little evidence for the validity of this assumption exists. This review investigates the current state of knowledge with respect to the understanding of the characteristics and mineralogy of large particles and how these influence leaching in a heap context and the tools to characterize these. This includes the study of ore and particle properties, visualization techniques for ore characterization, the connection between comminution and leaching behaviour, as well as particle models within heap leach modelling. We contend that the economics of heap leaching are strongly governed by the trade-off between the slow rate and limited extent of leaching from large particles and the cost of crushing finer. A sound understanding of the underlying large particle effects will therefore greatly inform future technology choices in the area of heap leaching. 相似文献
30.
Dynamic wetting and heat transfer at the initiation of aluminum solidification on copper substrates 总被引:1,自引:0,他引:1
Dominique Bouchard Sébastien Leboeuf Jean-Paul Nadeau Roderick I. L. Guthrie Mihaiela Isac 《Journal of Materials Science》2009,44(8):1923-1933
Dynamic wetting and heat transfer during the start of solidification were studied with the help of molten aluminum droplets
falling from a crucible onto a copper substrate. A high-speed camera captured the change in the spreading droplet’s geometry,
while thermocouple, inserted inside the substrate, allowed a heat transfer analysis to be performed. Droplet spreading factors
and interfacial heat fluxes were then used to, respectively, characterize dynamic wetting and heat transfer for the various
experimental conditions explored. These were: (1) effects of chemical composition of the aluminum alloy, (2) initial temperature
of the substrate, (3) surface roughness of the substrate, and (4) composition of the gaseous atmosphere. The experiments were
all carried out in gaseous atmospheres containing oxygen in sufficient amount to form oxide skins at the surface of the droplets
and the substrates. The results showed instances where an improvement in the dynamic wetting was accompanied by an increase
in heat transfer during the early stages of solidification but this was not systematic. In these cases where a positive correlation
was not observed, it was postulated this was caused by factors such as variations in the oxidation at the surface of the substrates
and the droplets as well as gas trapped at the interface between the droplets and the substrates.
Sébastien Leboeuf formerly with the Aluminum Technology Centre and McGill University. 相似文献