Testing mediators of intervention effects in randomized controlled trials: An evaluation of three depression prevention programs.

Objective: Evaluate a new 5-step method for testing mediators hypothesized to account for the effects of depression prevention programs. Method: In this indicated prevention trial, at-risk teens with elevated depressive symptoms were randomized to a group cognitive–behavioral (CB) intervention, group supportive expressive intervention, CB bibliotherapy, or assessment-only control condition. Results: The group CB intervention reduced depressive symptoms and negative cognitions and increased pleasant activities. Change in these mediators predicted change in depression, and intervention effects became weaker controlling for change in the mediators; yet, change in depression appeared typically to occur before change in the mediators. The supportive expressive intervention reduced depressive symptoms but affected only 1 of 2 mediators (emotional expression but not loneliness). Change in emotional expression did not correlate with change in depression, and change in depression usually occurred before change in the mediators. Bibliotherapy did not significantly affect depressive symptoms or the ostensive mediators (negative cognitions and pleasant activities), and change in depression usually occurred before change in the mediators. Conclusion: Results imply that this procedure provides a sensitive test of mediation but yielded limited support for the hypothesized mediators, suggesting that nonspecific factors may play an important mediational role. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Testing Web applications by modeling with FSMs

Researchers and practitioners are still trying to find effective ways to model and test Web applications. This paper proposes a system-level testing technique that combines test generation based on finite state machines with constraints. We use a hierarchical approach to model potentially large Web applications. The approach builds hierarchies of Finite State Machines (FSMs) that model subsystems of the Web applications, and then generates test requirements as subsequences of states in the FSMs. These subsequences are then combined and refined to form complete executable tests. The constraints are used to select a reduced set of inputs with the goal of reducing the state space explosion otherwise inherent in using FSMs. The paper illustrates the technique with a running example of a Web-based course student information system and introduces a prototype implementation to support the technique.     

Maximum entropy direct models for speech recognition

Traditional statistical models for speech recognition have mostly been based on a Bayesian framework using generative models such as hidden Markov models (HMMs). This paper focuses on a new framework for speech recognition using maximum entropy direct modeling, where the probability of a state or word sequence given an observation sequence is computed directly from the model. In contrast to HMMs, features can be asynchronous and overlapping. This model therefore allows for the potential combination of many different types of features, which need not be statistically independent of each other. In this paper, a specific kind of direct model, the maximum entropy Markov model (MEMM), is studied. Even with conventional acoustic features, the approach already shows promising results for phone level decoding. The MEMM significantly outperforms traditional HMMs in word error rate when used as stand-alone acoustic models. Preliminary results combining the MEMM scores with HMM and language model scores show modest improvements over the best HMM speech recognizer.     

OWL-Eu: Adding customised datatypes into OWL

Although OWL is rather expressive, it has a very serious limitation on datatypes; i.e., it does not support customised datatypes. It has been pointed out that many potential users will not adopt OWL unless this limitation is overcome, and the W3C Semantic Web Best Practices and Development Working Group has set up a task force to address this issue. This paper makes the following two contributions: (i) it provides a brief summary of OWL-related datatype formalisms, and (ii) it provides a decidable extension of OWL DL, called OWL-Eu, that supports customised datatypes. A detailed proof of the decidability of OWL-Eu is presented.     

Customization of a Commercially Available Prep Scale SFC System to Provide Enhanced Capabilities

Preparative Scale Supercritical Fluid Chromatography is emerging as a powerful alternative to HPLC for the purification and separation of complex chemical reaction mixtures. Advantages include greatly reduced solvent usage (and thus lower cost and environmental impact), higher throughput, and in some cases higher resolution. While there are commercially available prep SFC instruments, none currently offer all the features desired by many medicinal chemists engaged in the drug discovery process. These include: the ability to collect an unlimited number of fractions per sample with high recovery and negligible carryover, fully automated capacity to collect several hundred fractions, and the ability to collect fractions into the same disposable test tubes and racks which are already employed in HPLC. This article describes the customization of a preparatory scale SFC system purchased from Berger Instruments, Inc., Newark, DE. (a subsidiary Mettler-Toledo International, Inc., of Greifensee, Switzerland) in order to provide these capabilities.     

Low-Power Parallel Video Compression Architecture for a Single-Chip Digital CMOS Camera

A low-power, large-scale parallel video compression architecture for a single-chip digital CMOS camera is discussed in this paper. This architecture is designed for highly computationally intensive image and video processing tasks necessary to support video compression. Two designs of this architecture, an MPEG2 encoder and a DV encoder, are presented. At an image resolution of 640 × 480 pixels (MPEG2) and 720 × 576 (DV) and a frame rate of 25 to 30 frames per second, a computational throughput of up to 1.8 billion operations per second (BOPS) is required. This is supported in the proposed architecture using a 40 MHz clock and an array of 40 to 45 parallel processors implemented in a 0.2 m CMOS technology and with a 1.5 V supply voltage. Power consumption is significantly reduced through the single-chip integration of the CMOS photo sensors, the embedded DRAM technology, and the proposed pipelined parallel processors. The parallel processors consume approximately 45 mW of power resulting a power efficiency of 40 BOPS/W.     

The surface energies of graphite

A discussion is presented describing the possible influence of the internal surface energy of polycrystalline and pyrolytic graphites on three phenomena: (a) the thermodynamic “standard” state of carbon, (b) the graphitization process, and (c) the structural stability of graphites at high temperatures. In order to do this, the surface enthalpies and free energies of the basal surface and edge faces have been calculated from a number of sources, and their temperature dependence up to 3000K discussed. Suggestions have been made for methods to measure both basal surface and “edge” surface energies more directly.