XScale架构分析及优化策略

XScale被广泛地应用于嵌入式系统,但是很多程序并没有充分利用XScale架构的各种优点,性能并不尽如人意。本文详细分析了IntelXScale架构,并提出如何基于XScale架构进行优化的策略,最后对实际应用程序进行优化,并给出测试结果。     

Clinical Breakpoint of Apramycin to Swine Salmonella and Its Effect on Ileum Flora

The purpose of this study was to establish the clinical breakpoint (CBP) of apramycin (APR) against Salmonella in swine and evaluate its effect on intestinal microbiota. The CBP was established based on three cutoff values of wild-type cutoff value (CO_WT), pharmacokinetic-pharmadynamic (PK/PD) cutoff value (CO_PD) and clinical cutoff value (CO_CL). The effect of the optimized dose regimen based on ex vivo PK/PD study. The evolution of the ileum flora was determined by the 16rRNA gene sequencing and bioinformatics. This study firstly established the CO_WT, CO_PD in ileum, and CO_CL of APR against swine Salmonella, the value of these cutoffs were 32 µg/mL, 32 µg/mL and 8 µg/mL, respectively. According to the guiding principle of the Clinical Laboratory Standards Institute (CLSI), the final CBP in ileum was 32 µg/mL. Our results revealed the main evolution route in the composition of ileum microbiota of diarrheic piglets treated by APR. The change of the abundances of Bacteroidetes and Euryarchaeota was the most obvious during the evolution process. Methanobrevibacter, Prevotella, S24-7 and Ruminococcaceae were obtained as the highest abundance genus. The abundance of Methanobrevibacter increased significantly when APR treatment carried and decreased in cure and withdrawal period groups. The abundance of Prevotella in the tested groups was significantly lower than that in the healthy group. A decreased of abundance in S24-7 was observed after Salmonella infection and increased slightly after cure. Ruminococcaceae increased significantly after Salmonella infection and decreased significantly after APR treatment. In addition, the genera of Methanobrevibacter and Prevotella were defined as the key node. Valine, leucine and isoleucine biosynthesis, D-Glutamine and D-glutamate metabolism, D-Alanine metabolism, Peptidoglycan and amino acids biosynthesis were the top five Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in the ileum microbiota of piglets during the Salmonella infection and APR treatment process. Our study extended the understanding of dynamic shift of gut microbes during diarrheic piglets treated by APR.     

Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells

Insulin-like growth factor 1 (IGF-1) not only regulates neuronal function and development but also is neuroprotective in the setting of acute ischemic stroke. G-protein-coupled receptor 17 (GPR17) expression in brain tissue serves as an indicator of brain damage. As whether IGF-1 regulates GPR17 expression remains unknown, the aim of this study is to investigate how IGF-1 regulates GPR17 expression in vitro. Human neuroblastoma SK-N-SH cells were used. Lentivirus-mediated short hairpin RNA (shRNA) was constructed to mediate the silencing of FoxO1, while adenoviral vectors were used for its overexpression. Verification of the relevant signaling cascade was performed using a FoxO1 inhibitor (AS1842856), a phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002), and a GPR17 antagonist (cangrelor). Cell proliferation was analyzed using EdU staining; immunofluorescence staining was used to detect the expression and subcellular localization of FoxO1. Chromatin immunoprecipitation was used to analyze the binding of FoxO1 to the GPR17 promoter in SK-N-SH cells. The expression of FoxO1, GPR17, and protein kinase B (also known as Akt) mRNA and protein as well as the levels of FoxO1 and Akt phosphorylation were investigated in this study. IGF-1 was found to downregulate FoxO1 and GPR17 expression in SK-N-SH cells while promoting cell viability and proliferation. Inhibition of FoxO1 and antagonism of GPR17 were found to play a role similar to that of IGF-1. Silencing of FoxO1 by lentivirus-mediated shRNA resulted in the downregulation of FoxO1 and GPR17 expression. The overexpression of FoxO1 via adenoviral vectors resulted in the upregulation of FoxO1 and GPR17 expression. Blocking of PI3K signaling by LY294002 inhibited the effect of IGF-1 on GPR17 suppression. Results from chromatin immunoprecipitation revealed that IGF-1 promotes FoxO1 nuclear export and reduces FoxO1 binding to the GPR17 promoter in SK-N-SH cells. Here, we conclude that IGF-1 enhances cell viability and proliferation in SK-N-SH cells via the promotion of FoxO1 nuclear export and reduction of FoxO1 binding to the GPR17 promoter via PI3K/Akt signaling. Our findings suggest that the enhancement of IGF-1 signaling to antagonize GPR17 serves as a potential therapeutic strategy in the management of acute ischemic stroke.     

海上平台电气系统无人化方案设计

目前国内外越来越多边际油田开发借助无人平台来实现,降低油田开发成本的同时,也对平台生产安全提出更高要求。无人平台电气系统的设计以系统网架结构简化为基础,以实现全面监测、远程调控和安全可靠运行为目的,以现有能量管理系统为基础平台,将电气系统、能量管理系统及各设备监测系统等联合实现远程管控,从而为海上油气生产提供可靠、安全的供电保障。主要探讨海上油气田工程设施电气无人化的设计方法,结合南海某海上油田工程设计案例,详细论述无人平台电气设计方案,从具体设计工作中提炼出符合海上平台电气系统的无人化通用做法,为海上油气田无人化的推广应用以及无人平台电气系统的设计提供参考和借鉴。     

Ultra-thin Body Buried In0.35Ga0.65As Channel MOSFETs with Extremely Low Off-current on Si Substrates

In this paper, we investigated the electrical properties of the Metal-oxide-semiconductor gate stack of Ti/Al2O3/InP under different annealing conditions. A min...     

Radial Clearance Control and Internal Leakage Analysis of a Tri-Proportion Controller

The tri-propellant thermal propulsion system is one of the hottest subjects in the field of underwater vehicles recently.To improve efficiency of underwater vehicles,a method of radial clearance control of the tri-proportion has been proposed.Based on analyzing the factors which influence the pressure decrease and leakage of the tri-proportion controller,a method is used for precision analysis and proportion adjustment by using the median optimizing theory.Analysis results show that accuracy of the proporti...     

机箱接线座多工位级进模设计

分析了冲件的结构特点与成形工艺,设计了级进模排样方案,介绍了一种利用自动送料初定位,导正钉精定位,导料浮料销导料,连续进行零件轮廓冲切、弯曲等多个工位,最终将成品切离坯料的多工位级进模具的设计。     

石英晶体微天平的研究进展及应用

介绍了石英晶体微天平的基本原理和结构,重点介绍了仪器研究进展及应用,包括常规石英晶体微天平（QCM）、耗散型石英晶体微天平（QCM-D）、阵列式石英晶体微天平与电化学石英晶体微天平（EQCM）。     

中厚板轧制规程优化设计系统的开发及应用

本文根据中厚板轧制规程设计的要求,用Visual BASIC开发出中厚板轧制规程优化设计系统.系统可按设备能力、产品产量、板形和平面形状等质量要求进行轧制规程设计.系统应用于生产实际取得良好效果.