Robust and accurate registration of 2-D electrophoresis gels using point-matching.

Point-matching is a widely applied image registration method and many algorithms have been developed. Registration of 2-D electrophoresis gels is an important problem in biological research that presents many of the technical difficulties that beset point-matching: large numbers of points with variable densities, large nonrigid transformations between point sets, paucity of structural information and large numbers of unmatchable points (outliers) in either set. In seeking the most suitable algorithm for gel registration we have evaluated a number of approaches for accuracy and robustness in the face of these difficulties. Using synthetic images we test combinations of three algorithm components: correspondence assignment, distance metrics and image transformation. We show that a version of the iterated closest point (ICP) algorithm using a non-Euclidean distance metric and a robust estimation of transform parameters provides best performance, equalling SoftAssign in the presence of moderate image distortion, and providing superior robustness against large distortions and high outlier proportions. From this evaluation we develop a gel registration algorithm based on robust ICP and a novel distance metric combining Euclidean, shape context and image-related features. We demonstrate the accuracy of gel matching using synthetic distortions of real gels and show that robust estimation of transform parameters using M-estimators can enforce inverse consistency, ensuring that matching results are independent of the order of the images.     

Modelling methodology for thermal analysis of hot solder dip process

The shift of electronics industry towards the use of lead-free solders in components manufacturing brought also the challenge of addressing the problem of tin whiskers. Manufacturers of high reliability and safety critical equipment in sectors such as defence and aerospace rely increasingly on the use of commercial-of-the-shelf (COTS) electronic components for their products and systems. The use of COTS components with lead-free solder plated terminations comes with the risks for their long term reliability associated with tin whisker growth related failures. In the case of leaded type electronic components such as Quad Flat Package (QFP) and Small Outline Package (SOP), one of the promising solutions to this problem is to “re-finish” the package terminations by replacing the lead-free solder coatings on the leads with conventional tin–lead solder. This involves subjecting the electronic components to a post-manufacturing process known as Hot Solder Dip (HSD). One of the main concerns for adopting HSD (refinishing) as a strategy to the tin whisker problem is the potential risk for thermally induced damage in the components when subjected to this process.     

Mapping of Discrete Cosine Transforms onto Distributed Hardware Architectures

We present an algorithmically-aware, high-level partitioning methodology for discrete cosine transforms (DCT) targeted to distributed hardware architectures. The methodology relies on the exploration of alternate DCT formulations as part of the partition optimization process. To the best of our knowledge, no previously proposed DCT algorithm exists that is capable of consistently producing alternate regular formulations for an n-size DCT. Hence, a new Cooley-Tukey-like DCT factorization algorithm was developed to allow exploration of alternate formulations as part of the partitioning optimization process. The use of our factorization mechanism along with a greedy strategy to explore the space of equivalent DCT formulations yielded partitioning solutions with as much as 18% reduction in latency and 83% reduction in run-time as compared to previously proposed regular DCT formulations.

Dynamic group multicast routing with bandwidth reservations

Multicasting refers to the transmission of data from a source node to multiple destination nodes in a network. Group multicasting is a generalization of multicasting whereby every member of a group is allowed to multicast messages to other members that belong to the same group. The routing problem in this case involves the construction of a set of low cost multicast trees with bandwidth requirements, one for each member of the group for multicasting messages to other members of the group. In this paper, we examine this routing problem with an additional requirement that member nodes are allowed to join and leave the multicasting group anytime during a session. We call this problem, the dynamic group multicast routing problem (DGMRP). In this paper, we proposed three heuristic algorithms to generate a set of low cost multicast trees with dynamic group membership. Results from our empirical study shows that the one of the proposed algorithms, called Maximum bandwidth bottleneck path selection algorithm (MBBPS), achieves better utilization of bandwidth resources as compared with the other two algorithms which are based on a greedy approach. In addition MBBPS performs better in terms of cost when the bandwidth is not sufficient in the network. Copyright © 2002 John Wiley & Sons, Ltd.     

先进封装电镀中活性边界层的减薄

晶圆表面如果有一层薄且均匀的流体边界层,将有助于克服光刻图形带来的挑战,得到更均匀的金属沉积层。     

数据通信市场上的高速多层铜互连系统

数据信息永远不能满足整个社会的需求.因此,处理信息的计算、存储和交换系统对于更大数据吞吐能力的需求也在不断提高.在过去的五年时间里,处理能力有了巨大的提升,因此,更加迫切地需要适用于系统间移动海量数据更好、更高效的方法.     

Amphiphilic Polymeric Nanocarriers with Luminescent Gold Nanoclusters for Concurrent Bioimaging and Controlled Drug Release

Multifunctional theranostic systems with good biocompatibility, strong clinical imaging capability, and target specificity are the desired features of future medicine. Here, the design of a theranostic nanocomposite capable of simultaneous targeting and imaging of the cancer cells is presented. It releases its drug payload by a controlled release mechanism. The nanocomposite contains luminescent gold nanocluster (L‐AuNC) photostable and biocompatible diagnostic probes conjugated to a folic acid (FA)‐modified pH‐responsive amphiphilic polymeric system for controlled drug release. The nanocomposite uses a core‐satellite structure to encapsulate hydrophobic drugs and releases the drug payload in mildly acidic endosomal/lysosomal compartments by the action of the pH‐labile linkages in the polymer. In vivo studies show the selective accumulation of the FA‐conjugated nanocomposite in tumor tissues by folate‐receptor‐mediated endocytosis. These findings demonstrate the potential of the nanocomposite as a nontoxic, folate‐targeting, pH‐responsive drug carrier that is useful for the early detection and therapy of folate‐overexpressing cancerous cells.     

CO/sub 2/ laser processing of alumina (Al/sub 2/O/sub 3/) printed circuit board substrates

We report the results of an investigation of the laser-material interaction processes involved in laser drilling of alumina, through the use of an enhanced peak power (2.5 kW) CO/sub 2/ laser and novel temporal pulse formats. Peak power was varied from 30 W to 2 kW for pulses of constant energy to observe the effect produced on scribe depth. High-speed videography of hole formation has been combined with microscopic analysis to investigate the key processes involved in laser processing of alumina. Plasma screening was observed for short, high peak power laser pulses, and optimal scribing was achieved in the weakly plasma absorbing regime. A new processing technique for scribing alumina has been developed, which exploits the fast response of the laser to produce novel temporal pulse shapes, which can be modified to generate cleaner holes. Scribe speeds of up to 280 mm/spl middot/s/sup -1/ were obtained for scribe holes >200 /spl mu/m deep and 150 /spl mu/m apart, with no material plugging the hole, in 0.635-mm-thick 96% alumina.     

口香糖大小的开放源码SBC

美国一家小公司gumstix开发了只有口香糖大小的基于200 MHz和400MHz Inter XScale PXA255处理器的微型计算机。这是一款开放源码的硬件设备，所有图表和数据都可在该公司的网站上免费获得。     

Shorted fractal Sierpinski monopole antenna

This paper describes novel configurations of shorted fractal Sierpinski gasket antenna. The antenna uses half the structure of a conventional Sierpinski gasket antenna and is folded over to be parallel to the ground plane, to form an element similar to that of the inverted L antenna. A quasi log periodic resonance behavior is obtained with a shorting pin placed at the far end of the antenna. Several configurations are shown and a design using two shorting pins which improves the bandwidth at the fundamental band is also demonstrated.