龙王庙组气藏高温高压酸性大产量气井完井难点及其对策

为了实现对四川盆地安岳气田下寒武统龙王庙组气藏的安全高效开发,减少因冲蚀、腐蚀、丝扣渗漏和完井工艺不合理等因素所导致的安全屏障失效和环空异常带压等问题,在分析该气藏完井主要技术难点的基础上,重点进行了完井方式优选、管柱材质实验评价与优选、管柱丝扣密封性能评价、井下管柱结构优化设计以及管柱抗冲蚀性能评价等方面的研究与现场试验。形成了一套适合于高温、高压、含酸性介质、大产量气井的配套完井技术:(1)优选了适合的完井方式、管柱材质和扣型;(2)形成了不同配产条件下的管柱结构;(3)制订了针对直井和斜井的完井工艺及完井过程施工质量控制措施。现场应用效果表明,该配套技术有效降低了大产量生产对管柱和井下工具的冲蚀以及射孔作业对生产封隔器密封性能的影响,提高了完井施工质量,对于减少后期生产过程中环空异常带压具有较好的效果。可为类似气田的开发提供参考。     

对称非线性包层平板多量子阱波导TE模的传播特性

分别用精确计算和方均根近似方法得到了包层及衬底均为非线性Ｋｅｒｒ型介质、芯区为多量子阱的对称平板波导中ＴＥ模的传播特性。数值计算表明,当芯区多量子阱的层数较多时,方均根近似方法得到的结果与用精确方法得到的结果一致,此时多量子阱波导可以等效为均匀介质。对于自聚焦情况,在合适的光功率下,当分界面处包层（及衬底）的有效折射率与芯区折射率相等时,芯区的场分布呈均匀分布而两侧的场呈指数式衰减;功率继续增大时,场分布的极值进入芯区两侧,而芯区场分布呈下凹形。对于自散焦情况,波导对导波场有较强干线性波导的束缚作用,且随光功率的增大而增强。     

Generation of coherent radiation in XUV by fifth- and seventh-order frequency conversion in rare gases

Results of experimental studies of the generation of coherent radiation in the XUV by high order optical nonlinearities in the rare gases are described. Fifth- and seventh-harmonic conversion and six wave mixing of harmonic pulses from an Nd:YAG laser were used to produce radiation at several discrete wavelengths between 38 and 76 nm. Experimental measurements of fifth-haxmonic conversion of pump pulses at 266.1 nm in helium are compared with theoretical predictions. Discrepancies between theory and experiment are observed at high laser powers, and the role of competing processes is discussed.     

景洪水电站右冲沙底孔坝段加固处理设计

景洪水电站碾压混凝土重力坝坝顶高程612m，最大坝高110m，坝顶总长704m，其中右冲沙底孔坝段坝轴线方向长23．5m，水流向长270．7m。鉴于右冲沙底孔坝段，在施工期兼作一期、二期纵向围堰，在运行期又作为厂房右端墙的一部分，两侧将承受不同频率洪水位下的水压力，可能存在侧向失稳的问题，需对其侧向稳定性和基础应力进行复核计算。经复核计算发现，在二期导流期间，右冲沙底孔D0＋065m～D0＋240m段建基面抗倾覆稳定不能满足规范要求，且右侧垂直拉应力较大，有可能对坝体结构产生破坏。因此，有针对性地采取了一系列工程措施对右冲沙底孔D0＋065m～D0＋240m段进行了综合性的加固处理，从而确保了二期导流期间右冲沙底孔的安全及工程施工的顺利进行。     

由气水流场耦合求解圆板的垂直等速入水

为探讨气流对入水空泡的影响以及计算非定常空泡面上的压力分布，本文提出了一个用自由面和物面上的边值同时求解气、水流场的方法，对圆板垂直等速入水算例，获得了空泡深闭合的结果。空泡内压力在深闭合时的骤增趋势与实验一致。表明本方法用于计算存在自由面的二层不掺混不可压势流问题是有效的。     

Influence of omega fatty acids on skin permeation of a coenzyme Q10 nanoemulsion cream formulation: characterization,in silico and ex vivo determination

Objective: The aim of this study was to develop a coenzyme Q10 nanoemulsion cream, characterize and to determine the influence of omega fatty acids on the delivery of coenzyme Q10 across model skin membrane via ex vivo and in silico techniques.

Methods: Coenzyme Q10 nanoemulsion creams were prepared using natural edible oils such as linseed, evening primrose, and olive oil. Their mechanical features and ability to deliver CoQ10 across rat skin were characterized. Computational docking analysis was performed for in silico evaluation of CoQ10 and omega fatty acid interactions.

Results: Linseed, evening primrose, and olive oils each produced nano-sized emulsion creams (343.93–409.86?nm) and exhibited excellent rheological features. The computerized docking studies showed favorable interactions between CoQ10 and omega fatty acids that could improve skin permeation. The three edible-oil nanoemulsion creams displayed higher ex vivo skin permeation and drug flux compared to the liquid-paraffin control cream. The linseed oil formulation displayed the highest skin permeation (3.97?±?0.91?mg/cm²) and drug flux (0.19?±?0.05?mg/cm²/h).

Conclusion: CoQ10 loaded-linseed oil nanoemulsion cream displayed the highest skin permeation. The highest permeation showed by linseed oil nanoemulsion cream may be due to the presence of omega-3, -6, and -9 fatty acids which might serve as permeation enhancers. This indicated that the edible oil nanoemulsion creams have potential as drug vehicles that enhance CoQ10 delivery across skin.     

东海西湖凹陷A气田渐新统花港组三段厚层砂岩沉积环境

西湖凹陷A气田花港组三段巨厚碎屑岩储层为研究区主力产气层与优质储层,对其沉积微相的厘定争议较大。综合利用研究区岩心、测井、地震、分析化验等相关资料,研究了目的层相标志、微相类型、沉积环境与相分布。研究认为本区发育辫状河三角洲前缘亚相,主要发育水下分流河道微相与分流间湾微相,不发育反映海相及海侵的沉积物与相标志。垂向上多期水下分流河道砂体叠置、厚度较大,水平延伸好;平面上水下分流河道由东北逐渐向西南呈树枝状分叉、连片分布,物源来自东北部。明确研究区属于陆相背景下的湖泊-三角洲沉积体系,为典型的牵引流沉积,不见海侵层序,高能量牵引流的水下分流河道微相是本区高产气藏储层发育的有利因素。     

Targeted Nanoparticle‐Mediated Gene Therapy Mimics Oncolytic Virus for Effective Melanoma Treatment

Oncolytic virus has potential applications in cancer therapy. However, its clinical application is restricted by the virus‐associated biosafety issues. Here, inspired by the key role of vesicular stomatitis virus matrix protein (VSVMP) in the oncolytic vesicular stomatitis virus (VSV) induced apoptosis, a targeted nanoparticle‐delivered neutral VSVMP gene formulation is designed to act like the VSV for cancer therapy. This VSVMP formulation consists of a CRGDKGPDC peptide modified hybrid monomethoxy poly (ethylene glycol)‐poly(d ,l ‐lactide) nanoparticles complexed with VSVMP plasmid, having good blood compatibility and tumor targeting ability. The transfection efficiency is as high as that of VSV. After intravenous administration, the VSVMP formulation can efficiently target the tumor, significantly inhibit the melanoma growth and metastasis, prolong the survival time of tumor‐bearing mice, and does not cause obvious systemic toxicity. The anticancer mechanisms involve apoptosis induction, angiogenesis inhibition and some virus‐associated signal pathways activation. This work demonstrates a VSV‐inspired nonviral gene therapy that has promising clinical applications in melanoma treatment.