导弹弹射气体冲击载荷实验与仿真研究

设计一套模拟发射筒内建压过程的装置,使之能够模拟不同建压速度、不同终值压强时的发射筒内建压过程,进而对导弹弹射过程中导弹尾罩和其他结构受到的气体冲击载荷进行地面冷实验。分别对四种不同初始条件下的建压过程进行了实验,并对一种情况进行了数值模拟仿真。结果显示,实验设备通过调节柱塞两侧初始压力差和高压气缸初始压力,可以实现对不同建压速率、不同终值压强的模拟;在建压过程中模拟发射筒内存在明显涡流,尾罩中间部位受压更大,变形时间相较于升压时间存在明显滞后。     

螺杆锚桩竖向拉拔试验对桩周土影响范围的试验研究

螺杆锚桩可适用于多种土层地质,其具有承载力高、装配式安装、工作效率高等诸多优点,在岩土工程中受到越来越广泛地应用。但螺杆桩变截面的独特设计使其在承载机理与受力特点等方面比普通桩型更加复杂,对其受荷状态下对周土的影响规律尚缺少关键的试验验证,这进一步限制了螺杆桩更广泛的工程应用。本文基于番禺某试验基地对两根不同桩径的钢螺杆锚桩进行竖向承载力抗拔试验,采用现场原位试验方法,对比分析不同位置地表沉降特性及旁桩位移特点,研究螺杆锚桩在静载试验中受荷状态下对周边地表与旁桩的影响情况及力学规律。研究结果显示:螺杆锚桩桩径与对桩周边地表的影响呈正相关,且施加的上拔荷载越大,桩径的影响越明显;随着试验荷载的增加,旁桩的竖向位移和水平位移均增加,最大影响范围在5倍桩径(D)以内;周边地表距锚桩由近至远呈现先隆起后下沉的力学规律。本文研究为螺杆桩在工程中尤其是静载试验锚桩的推广应用提供了工程实例与试验方法。     

特低渗透各向异性油藏井网加密储量动用规律

在特低渗透油藏中,由于高渗透条带的发育,通常使其表现出渗透率各向异性特征,导致注采井间的渗流规律与常规油藏不同,对井网加密形式的适应性也存在差异。基于各向异性油藏的渗流特点及井网调整形式,利用叠加原理,得到注采平面渗流场计算公式;引入线状排驱概念,对各向异性油藏井网加密形式进行适应性分析;用驱动压力梯度表征储量动用程度,提出无因次动用提高程度概念,建立定量表征注采井间储量动用规律的方法。结果表明,将初始正方形反九点井网系统地调整为排状加密井网,形成线状排驱,可有效提升特低渗透各向异性油藏的储量动用程度;初始井网井距大于400 m时,注采井间储量动用提升潜力较大。     

隐私保护DNA序列汉明距离计算问题

DNA序列承载着人体重要的生物学信息，如何在保护隐私的情况下正确地对不同的DNA序列进行比对，成为亟待研究的科学问题。汉明距离在一定程度上刻画了两个DNA序列的相似程度，在保护隐私的情况下，研究DNA序列的汉明距离计算问题。首先定义了DNA序列的0-1编码规则，该规则将长度为n的DNA序列编码成长度为4n的0-1串，证明了两个DNA序列的汉明距离等于它们的0-1编码串的汉明距离的一半。以此结论为基础，以GM加密算法为主要密码学工具，构造了计算DNA序列汉明距离的一个安全两方计算协议。在半诚实攻击者模型下，证明了协议的正确性，给出了基于模拟器的安全性证明，并对协议的效率进行了分析。     

A novel minimum weight formulation of topology optimization implemented with reanalysis approach

In this paper, we develop an efficient diagonal quadratic optimization formulation for minimum weight design problem subject to multiple constraints. A high-efficiency computational approach of topology optimization is implemented within the framework of approximate reanalysis. The key point of the formulation is the introduction of the reciprocal-type variables. The topology optimization seeking for minimum weight can be transformed as a sequence of quadratic program with separable and strictly positive definite Hessian matrix, thus can be solved by a sequential quadratic programming approach. A modified sensitivity filtering scheme is suggested to remove undesirable checkerboard patterns and mesh dependence. Several typical examples are provided to validate the presented approach. It is observed that the optimized structure can achieve lighter weight than those from the established method by the demonstrative numerical test. Considerable computational savings can be achieved without loss of accuracy of the final design for 3D structure. Moreover, the effects of multiple constraints and upper bound of the allowable compliance upon the optimized designs are investigated by numerical examples.     

谷氨酰胺代谢在原发性肝癌发生发展及治疗中的研究进展

肝癌是我国高发并且危害性极大的恶性肿瘤，其具有高死亡率并起病隐匿等特点。目前，肝癌治疗主要是以靶向药物，手术和放化疗为主，容易出现复发率高、耐药性强等现象。本文以谷氨酰胺代谢为切入点，对目前研究较多的肝癌相关的谷氨酰胺代谢酶及相关基因分别予以综述，以期为肝癌的发病机制及药物治疗提供开放性新思路。     

Numerical Simulation and Risk Assessment of Water Inrush in a Fault Zone that Contains a Soft Infill

Mine Water and the Environment - A numerical model was established to simulate the activation of the fault zone with a soft infill during a water inrush event. Distribution of the failed areas at...     

Temporal Changes of Phospholipids Fatty Acids and Cholesterol in Breast Milk and Relationship with Diet

Phospholipids (PLs) and cholesterol in human milk (HM) are affected by lactation, and differential lipids are closely related to maternal diet. The contents of PLs and cholesterol in Chinese HM are quantified by gas chromatography and high performance liquid chromatography, respectively, and the relationship between differential lipids and the maternal diet is obtained by Pearson. The result shows that SFA, MUFA, and polyunsaturated fatty acid (PUFA) are not affected by lactation and geography for total fatty acids, but almost all sn‐2 fatty acids are influenced by geography and remain unchanged during lactation. Most SFAs show absolute sn‐2 selectivity and the majority of MUFAs and PUFAs are esterified at the sn‐1 position. Cholesterol (13.8–22.6 mg per 100 g milk) and 25‐hydroxycholesterol (0.45–1.01 mg per 100 g milk) increase significantly and remain constant during lactation, respectively, and they are affected by regions. In addition, the differential lipids (22:1n‐9, C9:0, trans‐PUFA, 22:4n‐6, etc.) of PLs are closely related to the maternal diet. PLs and cholesterol content differ from western research and infant formula, which will help to design an infant formula that is more suitable for Chinese babies in the future. Practical Application: Compared with PLs and cholesterol in western countries and infant formula, the specificity of Chinese HM can more accurately target the development of formulas suitable for the growth of Chinese infants. At the same time, according to the influence of the mother?s diet on the composition of HM, it is more reasonable to guide the diet of the mother.