Intraocular concentrations of chemotherapeutic agents after systemic or local administration

OBJECTIVES: To investigate the concentrations of carboplatin and etoposide achieved in the aqueous and vitreous humors after intravenous infusion in nonhuman primates, and to investigate whether local administration of carboplatin might result in higher concentrations in the vitreous humor. METHODS: Macaca fascicularis primates were treated with 1 of 3 regimens: (1) intravenous carboplatin (18.7 mg/kg), etoposide (5 mg/kg), and vincristine sulfate (0.05 mg/kg), (2) peribulbar carboplatin (10 mg/mL), or (3) episcleral balloon carboplatin (10 mg/mL). Concentrations of chemotherapeutic agents were measured in the plasma and in the aqueous and vitreous humors. RESULTS: No measurable amount of etoposide was detected in the aqueous or vitreous humor after intravenous administration. Mean measured peak vitreous concentration of carboplatin after intravenous administration was 0.31 microg/mL, which was 1% of the peak plasma value. Mean measured peak vitreous concentrations of carboplatin after peribulbar or episcleral balloon administration were 2.38 microg/mL and 2.95 microg/mL, respectively, which represent 7.68- and 9.52-fold increases over the concentration achieved after intravenous administration. No serious toxic effect was observed in any animal. CONCLUSIONS: Peribulbar and episcleral balloon administration of carboplatin seemed to be safe and resulted in higher vitreous concentrations than intravenous administration in this model. These results suggest that these alternate routes of delivery should be explored in children with vitreous seeding of retinoblastoma.     

本钢烧结矿冷却及其余热回收的试验研究

从烧结矿冷却并回收其余热的角度出发，介绍了利用烧结机尾落矿空间，采用喷吹空气装置对烧结矿进行冷却的小型模拟试验，从测出的结果来看，有可能成为一种新的烧结矿冷却方式。     

连续流动分析仪应用于水中硫化物的测定

对连续流动法测定硫化物进行初步探讨和研究。同时与其他几种测定硫化物的方法进行了比较。实验结果表明，连续流动法对硫化物分析在线性、稳定性、最低检测限、准确性和精密度等方面均优于其他方法。     

In situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology

A novel processing technology was developed to investigate in situ synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. Thermodynamic analysis was performed to predict possible starting materials and synthesizing conditions of TiC-Al (Ti) nanocomposite powders. A mathematical model was developed to describe temperature profile and velocity distribution in the reactor. The model is applied to optimize feeding rate, input power, and other processing parameters of TiC-Al (Ti) nanocomposite powders by thermal plasma technology, and to predict which materials can be used as starting materials. This paper emphasizes the investigation of the effect of feeding rate, input power, mole ratio, and other process parameters on synthesis of TiC-Al (Ti) nanocomposite powders by thermal plasma technology. The experimental results showed that TiC-Al (Ti) nanocomposite powders can be synthesized in situ by thermal plasma technology, and the average size of TiC-Al (Ti) nanocomposite powders was less than 100 nm.     

试论当代中国邪教的基本特征及其防范措施

在论述邪教基本内涵的基础上,着重从五个方面分别阐述了当代中国邪教的基本特征及其防范的主要措施.     

供水系统信息化技术应用探讨

保证水量，提高水质，保障安全，优质服务和降低成本是城市供水系统当前的主要任务，而自动化和信息化则是完成该任务的重要技术手段。     

基于μC/OS-Ⅱ操作系统的液晶驱动解决方案

介绍了一种基于μC/OS-Ⅱ操作系统的LCD驱动程序,给出了硬件结构和软件模块.采用文中提出的显示缓冲区 屏幕刷新的方法,完全能够实现静态文本与滚屏动画的显示功能.     

VXIbus模块仪器在电路印制板故障诊断系统中的应用

本文介绍了一个由VXIbus模块仪器组建的用于电路印制板故障诊断的自动测试系统,具体的讨论了组建中的主控计算机和接口控制器的选择及被测单元与自动测试设备之间通用接口设计等问题。在文章的最后,给出了测试软件设计实例。实际应用表明,VXIbus模块仪器的应用,为电路印制板故障诊断系统提供了优良的测试性能,使系统的实用行、通用性、灵活性及自动化程度得到了明显的提高。     

单嘴精炼装置真空室内卷渣水模型研究

本文针对长城特殊厂单嘴精炼装置进行了真空室内加渣精炼的卷渣水模型研究。在试验的基础上，首先讨论了真空室内卷渣现象的工艺过程，然后进一步得出了临界吹气量的表达式。研究结果为工业性生产进一步提高钢的质量打下了基础。     

Nonparametric change detection and estimation in large-scale sensor networks

The problem of detecting changes in the distribution of alarmed sensors is considered. Under a nonparametric change detection framework, several detection and estimation algorithms are presented based on the Vapnik-Chervonenkis (VC) theory. Theoretical performance guarantees are obtained by providing error exponents for false-alarm and miss detection probabilities. Recursive algorithms for the efficient computation of test statistics are derived. The estimation problem is also considered in which, after detection is made, the location with maximum distribution change is estimated.