Shape from Shading Using Probability Functions and Belief Propagation

Shape-from-shading (SFS) aims to reconstruct the three-dimensional shape of an object from a single shaded image. This article proposes an improved framework based on belief propagation for computing SFS. The implementation of the well-known brightness, integrability and smoothness constraints inside this framework is shown. We implement the constraints as probability density functions. For example, the brightness constraint is a two-dimensional probability density function that relates all possible surface gradients at a pixel to their probability given the pixel intensity. A straightforward extension of the framework to photometric stereo is presented, where multiple images of the same scene taken under different lighting conditions are available. The results are promising, especially since the solution is obtained by iteratively applying simple operations on a regular grid of points. The presented framework therefore can be implemented in parallel and is a reasonably likely biological scheme.     

Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation

Long COVID (LC) describes the clinical phenotype of symptoms after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Diagnostic and therapeutic options are limited, as the pathomechanism of LC is elusive. As the number of acute SARS-CoV-2 infections was and is large, LC will be a challenge for the healthcare system. Previous studies revealed an impaired blood flow, the formation of microclots, and autoimmune mechanisms as potential factors in this complex interplay. Since functionally active autoantibodies against G-protein-coupled receptors (GPCR-AAbs) were observed in patients after SARS-CoV-2 infection, this study aimed to correlate the appearance of GPCR-AAbs with capillary microcirculation. The seropositivity of GPCR-AAbs was measured by an established cardiomyocyte bioassay in 42 patients with LC and 6 controls. Retinal microcirculation was measured by OCT–angiography and quantified as macula and peripapillary vessel density (VD) by the Erlangen-Angio Tool. A statistical analysis yielded impaired VD in patients with LC compared to the controls, which was accentuated in female persons. A significant decrease in macula and peripapillary VD for AAbs targeting adrenergic β2-receptor, MAS-receptor angiotensin-II-type-1 receptor, and adrenergic α1-receptor were observed. The present study might suggest that a seropositivity of GPCR-AAbs can be linked to an impaired retinal capillary microcirculation, potentially mirroring the systemic microcirculation with consecutive clinical symptoms.