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排序方式: 共有1872条查询结果,搜索用时 15 毫秒
81.
Binbin Chen Nicolas Gauquelin Daen Jannis Daniel M. Cunha Ufuk Halisdemir Cinthia Piamonteze Jin Hong Lee Jamal Belhadi Felix Eltes Stefan Abel Zoran Jovanović Matjaž Spreitzer Jean Fompeyrine Johan Verbeeck Manuel Bibes Mark Huijben Guus Rijnders Gertjan Koster 《Advanced materials (Deerfield Beach, Fla.)》2020,32(50):2004995
82.
In this paper, we are exploring the approach to utilize system-specific static analyses of code with the goal to improve software
quality for specific software systems. Specialized analyses, tailored for a particular system, make it possible to take advantage
of system/domain knowledge that is not available to more generic analyses. Furthermore, analyses can be selected and/or developed
in order to best meet the challenges and specific issues of the system at hand. As a result, such analyses can be used as
a complement to more generic code analysis tools because they are likely to have a better impact on (business) concerns such
as improving certain software quality attributes and reducing certain classes of failures. We present a case study of a large,
industrial embedded system, giving examples of what kinds of analyses could be realized and demonstrate the feasibility of
implementing such analyses. We synthesize lessons learned based on our case study and provide recommendations on how to realize
system-specific analyses and how to get them adopted by industry. 相似文献
83.
Johan Gabrielsson Kristoffer Andersson Gunnar Tobin Carina Ingvast-Larsson Mats Jirstrand 《Computer methods and programs in biomedicine》2014
We developed a computer program for use in undergraduate and graduate courses in pharmacology, pharmacokinetics and pharmacodynamics. This program can also be used in environmental and toxicological studies and preclinical simulation, to facilitate communication between modeling pharmacokineticists and project leaders or other decision-makers in the pharmaceutical industry. The program simulates the drug delivery and transport by means of (I) a six-compartment physiological pharmacokinetic flow model, (II) a system of traditional compartment models, or (III) a target-mediated drug disposition system. The program also can be used to simulate instantaneous equilibria between concentration and pharmacodynamic response, or as temporal delays between concentration and response. The latter is done by means of turnover models (indirect response models). Drug absorption, distribution, and elimination are represented by differential equations, which are described by organ and tissue volumes or other volumes of distribution, blood flows, clearance terms, and tissue-to-blood partition coefficients. The user can control and adjust these parameters by means of a slider in real time. By interactively changing the parameter values and simultaneously displaying the resulting concentration–time and/or response–time profiles, users can understand the major mechanisms that govern the disposition or the pharmacological response of the drug in the organism in real time. Schedule dependence is typically seen in clinical practice with a non-linear concentration–response relationship, and is difficult to communicate except via simulations. Here, we sought to illustrate the potential advantages of this approach in teaching pharmacology, pharmacokinetics, and pharmacodynamics to undergraduate pharmacy-, veterinary-, and medical students or to project teams in drug discovery/development. 相似文献
84.
Joelle Ilunga Kongolo Laura Suzanne Da Silva Obiro Cuthbert Wokadala Belinda Du Plessis Johan Husselman Mduduzi E. K. Ngcobo Naushad M. Emmambux Mieke Daneel 《Sensing and Instrumentation for Food Quality and Safety》2017,11(3):1056-1064
Unripe banana flour is a potential commercial ingredient in various food products for increased resistant starch and reduced gluten contents. In the present study, the pasting (rapid visco-analysis), gel texture (penetration test), thermal (differential scanning calorimetry), colour (tri-stimulus colour indices) and the resistant starch properties of unripe banana flour produced from different dessert banana varieties (n?=?10) cultivated in South Africa, were analysed and juxtaposed to wheat and maize flour. The functional properties varied significantly (p?≤?0.05) between banana varieties, and from wheat and maize flours, to various extents. Selected functional property ranges of unripe banana, wheat and maize flours, respectively included; flour colour index (63.16–76.42, 77.34 and 80.96), paste viscosity (405.5–556.6, 124.7 and 115.6 RVU), gelatinization temperature (64.67–71.21, 71.11 and 69.95?°C), gel firmness (7.24–11.44?×?10??2 N, 3.49?×?10??2 N and 6.56?×?10??2 N) and resistant starch content (19.9–47.4, 2.8 and 2.2% w/w). Multivariate analysis (principle component analysis) showed that the unripe banana flours from different varieties were distinguished from each other based on the pasting temperature. The unripe banana flours were distinguished from both wheat and maize flour based on breakdown and peak paste viscosities. The breakdown viscosity was the most positively related measure to the resistant starch content with a linear regression R-squared value of 0.898, indicating a significant role played by granule structure in resistance to enzymatic hydrolysis. The present research demonstrates that selection of appropriate dessert banana variety is important when replacing staple flours (wheat and maize) with unripe dessert banana flour as a functional ingredient. 相似文献
85.
Bram Pynoo Jo Tondeur Johan van BraakWouter Duyck Bart SijnavePhilippe Duyck 《Computers & Education》2012,58(4):1308-1317
In this study, teachers' acceptance and use of an educational portal is assessed based on data from two sources: usage data (number of logins, downloads, uploads, reactions and pages viewed) and an online acceptance questionnaire. The usage data is extracted on two occasions from the portal's database: at survey completion (T1) and twenty-two months later (T2). Framework for this study is C-TAM-TPB (Combined Technology Acceptance Model and Theory of Planned Behavior). 919 usable responses from teachers are obtained. Based on the observed use data at T1, four types of portal users are distinguished: ‘new’ (N = 37), ‘light’ (N = 641), ‘medium’ (N = 201), and ‘heavy’ (N = 40). Path analyses show that all predictor variables in C-TAM-TPB influence teachers' portal acceptance, but their significance level varies depending on the user type. The strongest predictors of behavioral intention to use the portal are attitude (‘new’) and perceived usefulness (‘light’, ‘medium’ and ‘heavy’), with variance explained ranging from .39 (‘medium’) to .71 (‘heavy’). The observed use data show that the portal is primarily used to search for and download material, rather than for sharing material or information. The use data at T2 show that teachers become more efficient in their search behavior and that the majority of the teachers use the portal more frequently. Guidelines are proposed to policymakers and school boards aiming to introduce a similar technology to teachers. 相似文献
86.
Johan G. F. Belinfante 《Journal of Automated Reasoning》2013,50(2):135-146
The GOEDEL program is an ever-growing collection of currently more than thirty thousand rewrite rules for transforming expressions in Gödel’s class theory in the hope of thereby simplifying them. A brief survey of the program and its use is presented. A few striking results obtained recently using the program are featured to provide some of the flavor of the author’s on-going research over the past fifteen years. 相似文献
87.
88.
Wouter van Riel Johan Post Jeroen Langeveld Paulien Herder 《Structure and Infrastructure Engineering》2017,13(7):855-868
Operational decision-making processes for networked infrastructure management often occur as a multi-actor planning problem, implying these are based on negotiations between different stakeholders in addition to available system quality information. As such, does more accurate data about actual structural condition lead to other or better decision-making? A serious game is introduced, Maintenance in Motion, aiming at investigating the influence of information quality on rehabilitation decisions, for single- and multi-actor decision-making. Players manage drinking water, gas, sewer and street infrastructures. They are to balance their individual goal, cost-effectiveness, with their team utility, increasing overall infrastructure quality to minimise failure while minimising overall public costs. The game design, calibration and solution space are presented. 相似文献
89.
Multimedia Tools and Applications - Searching for relevant 3D models based on hand-drawn sketches is both intuitive and important for many applications, such as sketch-based 3D modeling and... 相似文献
90.
Johan Oppen David L. Woodruff 《International Transactions in Operational Research》2009,16(5):627-640
Algorithms that search for good solutions to optimization problems present a trace of current best objective values over time. We describe an empirical study of parametric models of this progression that are both interesting as ways to characterize the search progression compactly and useful as means of predicting search behavior. In our computational experiments, we give examples of a variety of problems and algorithms where we are able to use the parametric models to make predictions of performance that cross instances and instance sizes. 相似文献