Integrated light scattering as a function of wavelength in donor lenses.

The purpose of this work is to investigate the light-scattering properties of excised eye lenses with intact lens capsules--more specifically, to compare light scattering with light transmission at different wavelengths in aging and cataractous lenses. A lens is positioned at its focal-length distance from an optical fiber end and collimates the light from one of five laser lines (458-633 nm). By use of an integrating sphere with an extra circular port, the collimated directly transmitted light can be separated from the scattered light. For lenses with low light-scattering levels, integrated scattering showed a dependence on wavelength, but when light scattering increased the wavelength difference tended to level out. Despite the higher percentage of lens light scattering at lower wavelengths, when calculated as an "effective light scattering" (compensated for light transmission), more scattered light actually falls toward the retina at longer wavelengths.     

Does sodium fluoride in bone cement affect implant fixation? Part I: Bone tissue response, implant fixation and histology in nine rabbits

The addition of sodium fluoride to poly (methyl-methacrylate) (PMMA) bone cement may theoretically improve the fixation of joint replacement. This hypothesis was tested in an animal model using nine mature healthy lop-eared rabbits. A femoral prosthesis was inserted in both knees to resurface the patellofemoral articulation. The same acrylic cement, with and without sodium fluoride, was randomised between the two sides for prosthetic fixation. Two screw shaped implants machined from cured rods of either cement were also inserted bilaterally into the proximal tibia. Qualitative and quantitative histomorphometry of the bone tissue response surrounding the cement in the femur and the intact tibial implants revealed similar results regardless of sodium fluoride addition. Six weeks after surgery removal, torque did not significantly differ between the two sides. Our findings indicate that addition of sodium fluoride to PMMA has little effect on implant stability and bone remodeling in rabbits in the short-term.     

Parallel flow measurements in microstructures by use of a multifocal 4 x 1 diffractive optical fan-out element

We have developed a multifocal optical fluorescence correlation spectroscopy system for parallel flow analyses. Multifocal excitation was made possible through a 4 x 1 diffractive optical fan-out element, which produces uniform intensity in all four foci. Autocorrelation flow analyses inside a 20 microm x 20 microm square microchannel, with the 4 x 1 fan-out foci perpendicular to the flow direction, made it possible to monitor different flows in all four foci simultaneously. We were able to perform cross-correlation flow analyses by turning the microstructure, thereby having all four foci parallel to the direction of flow. Transport effects of the diffusion as a function of flow and distance could then also be studied.     

Protein identification by MALDI-TOF-MS peptide mapping: a new strategy

A new strategy for identifying proteins by MALDI-TOF-MS peptide mapping is reported. In contrast to current approaches, the strategy does not rely on a good relative or absolute mass accuracy as the criterion that discriminates false positive results. The protein sequence database is first searched for all proteins that match a minimum five of the submitted masses within the maximum expected relative errors when the default or externally determined calibration constants are used, for instance, +/-500 ppm. Typically, this search retrieves many thousand candidate sequences. Assuming initially that each of these is the correct protein, the relative errors of the matching peptide masses are calculated for each candidate sequence. Linear regression analysis is then performed of the calculated relative errors as a function of m/z for each candidate sequence, and the standard deviation to the regression is used to distinguish the correct sequence among the candidates. We show that this parameter is independent of whether the mass spectrometric data were internally or externally calibrated. The result is a search engine that renders internal spectrum calibration unnecessary and adapts to the quality of the raw data without user interference. This is made possible by a dynamic scoring algorithm, which takes into account the number of matching peptide masses, the percentage of the protein's sequence covered by these peptides and, as new parameter, the determined standard deviation. The lower the standard deviation, the less cleavage peptides are required for identification and vice versa. Performance of the new strategy is demonstrated and discussed. All necessary computing has been implemented in a computer program, free access to which is provided in the Internet.     

An Invasive Composition System for Local-to-Global Transformations

Transformation systems are particularly well suited to implement modular rules, transforming one language feature of the source language into a single or a composition of language features of the target language. However, in practice, transformation rules must be written which take one language feature and transform them into several language features belonging to various locations in the output program. The implementation of these so-called local-to-global transformations with rewrite rules is very complex and tightly coupled which imposes severe constraints on maintenance and evolvability. The four main coupling problems of the current-day implementations are presented and we indicate how these can be eliminated and reduced by our extension of the rewrite rule system. Furthermore we show how complex invasive compositions can be solved by abstract, reusable algorithms and mechanisms, rendering the implementation of local-to-global transformations into a semi-automatic process.     

General Adaptive Neighborhood Image Processing

The so-called General Adaptive Neighborhood Image Processing (GANIP) approach is presented in a two parts paper dealing respectively with its theoretical and practical aspects. The General Adaptive Neighborhood (GAN) paradigm, theoretically introduced in Part I [20], allows the building of new image processing transformations using context-dependent analysis. With the help of a specified analyzing criterion, such transformations perform a more significant spatial analysis, taking intrinsically into account the local radiometric, morphological or geometrical characteristics of the image. Moreover they are consistent with the physical and/or physiological settings of the image to be processed, using general linear image processing frameworks. In this paper, the GANIP approach is more particularly studied in the context of Mathematical Morphology (MM). The structuring elements, required for MM, are substituted by GAN-based structuring elements, fitting to the local contextual details of the studied image. The resulting morphological operators perform a really spatially-adaptive image processing and notably, in several important and practical cases, are connected, which is a great advantage compared to the usual ones that fail to this property.     

高密度电子封装器件的温度分布研究

系统封装(System In Packaging)是电子封装工艺的前沿技术。为了研究这种高密度电子封装器件的热特性,寻求提高散热速率的途径,开发了一个SIP典型器件的传热模型,模拟了器件的热传递过程和温度分布状况,探讨了各种设计参数和物性参数对温度场的影响,为进一步改善器件的热性能提供了理论依据。     

Active centers, catalytic behavior, symbiosis and redox properties of MoV(Nb,Ta)TeO ammoxidation catalysts

Selective as well as waste forming active centers were defined for MoVNbTeO and MoVTaTeO catalysts in the ammoxidation of propane to acrylonitrile and all catalytic functionalities were assigned to specific elements at the respective active centers. Symbiosis between M1 and M2 phases of these catalysts was observed, with phase cooperation being more extensive in the Nb than Ta containing compositions. The difference in catalytic effectiveness arises most likely because contact and surface area exposure of the two respective, cooperating phase pairs are not equal. The M1 phase of the catalysts is reducible by propane and ammonia in the absence of dioxygen and is regenerable to its original, fully oxidized state by dioxygen (air). No structural collapse is observed even after 120 C₃H₈ + NH₃ reduction pulses. The so induced reduction of the catalyst extends up to 70 layers deep. The product distribution over the first few pulses is very similar to that under catalytic conditions, supporting the concept that lattice oxygen is involved in the catalytic ammoxidation process. Therefore, the ammoxidation of paraffins is a redox process, as is of course the well-known olefin ammoxidation process.