模拟集成促进工厂整合

正模拟和混合信号IC的技术进步促进了前所未有的工厂生产力、效率、质量及安全性整合。这些IC使得系统性能更强、测量精度越来越高、通信更可靠、功耗更低,安全性更高;它们是工业系统的核心,根据大量传感器测量数据快速做出响应,高精度控制材料处理、工业过程的步骤、供电和温度,以及操作的安全性。当计算功能集成到这些模拟与混合信号IC时,工厂可采用分布式的智能管理模型。现在,工厂数据能够更     

Control point policy optimization using genetic algorithms

This paper describes the application of an integrated Genetic Algorithm (GA)/Discrete Event Simulation model for selecting optimum values for Critical Point Policy (CPP) hedging time and buffer size parameters. The CPP is shown to perform well, when compared with the Critical Ratio priority rule, in terms of improving service levels, particularly when subject to conditions where buffer sizes and Takt times are required to be small. The technique developed involves buffer sizes being chosen by a GA according to a constraint on the total storage space available within the system. A method is described for reducing the number of variables that the GA needs to deal with, hence, improving the efficiency of the GA optimization process. The development and application work reported also provides further understanding into how and when the CPP should be applied.     

Comparison of alteplase (tissue plasminogen activator) high‐dose vs. low‐dose protocol in restoring hemodialysis catheter function: The ALTE‐DOSE study

Hemodialysis catheter (HDC) dysfunction due to thrombosis is common, and dysfunction incidence can reach up to 50% within 1 year of use. Although administration of intraluminal alteplase (tissue plasminogen activator [tPA]) is the standard of practice to pharmacologically restore HDC function, there are no evidence‐based guidelines concerning the optimal tPA dose. The purpose of this study was to compare the efficacy of 1.0‐mg vs. 2.0‐mg tPA dwell protocols in restoring the HDC function in thrombotic dysfunctional catheters. A retrospective, single‐center study was conducted on two independent cohorts of patients; the first (n = 129) received 2.0 mg tPA/catheter lumen, while the second (n = 108) received 1.0 mg tPA/catheter lumen. Kaplan–Meier and Cox regression analyses were performed to compare the catheter survival time between patients who received 1.0 mg tPA and those who received 2.0 mg tPA. Catheter removal occurred in 25 (19.4%) of those catheters treated with 1.0 mg tPA compared with 11 (10.2%) of catheters treated with 2.0 mg tPA (P = 0.05). The hazard ratio (HR) for catheter removal was 2.75 (95% confidence interval [^95%CI] = 1.25–6.04) for the 1.0‐mg tPA cohort compared with the 2.0‐mg tPA cohort. Correction added on 3 December 2012, after first online publication: The tPA cohort values were changed. Female gender (HR = 2.51; ^95%CI = 1.20–5.27) and age (HR = 0.96; ^95%CI = 0.94–0.98) were also associated with catheter survival. Our findings suggest that treatment of dysfunctional HDC with 2.0‐mg tPA dwells is superior to 1.0‐mg tPA dwells.     

On the Importance of an Effective Quality Improvement Program

Abstract

Strong businesses are built on teams of people working together to get the job done. The team metaphor is the model on which to base future computing solutions. Applications for communication and routing, information exchange, process management, collaboration, and meetings are discussed.     

Towards an Understanding the Outcomes of Housing Privatisation in South Africa

Housing privatisation is commonly understood in political economic terms. The proponents of privatisation argue that the provision of ownership enables households to have security of tenure, which in turn leads to increased housing investment, the development of a secondary housing market and a source of income for the local authority by means of land tax. On the other hand, critics of housing privatisation suggest that such processes lead to landlordism and an increased dependence on mortgage finance. This paper uses historical methodology to trace the historical lack of secure tenure for urban black South Africans. The data consists of 395 structured questionnaires conducted in the case study area of Mangaung, the former black township of Bloemfontein. The results suggest that housing privatisation processes in South Africa cannot be viewed only through a political economic lens.     

Stable imposition of stiff constraints in explicit dynamics for embedded finite element methods

We investigate various strategies to enforce the kinematics at an embedded interface for transient problems within the extended finite element method. In particular, we focus on explicit time integration of the semi‐discrete equations of motion and extend both dual and primal variational frameworks for constraint enforcement to a transient regime. We reiterate the incompatibility of the dual formulation with purely explicit time integration and the severe restrictions placed by the Courant–Friedrichs–Levy condition on primal formulations. We propose an alternate, consistent formulation for the primal method and derive an estimate for the stabilization parameter, which is more amenable in an explicit dynamics framework. Importantly, the use of the new estimate circumvents the need for any tolerances as an interface approaches an element boundary. We also show that with interfacial constraints, existing mass lumping schemes can lead to prohibitively small critical time steps. Accordingly, we propose a mass lumping procedure, which provides a more favorable estimate. These techniques are then demonstrated on several benchmark numerical examples, where we compare and contrast the accuracy of the primal methods against the dual methods in enforcing the constraints. Copyright © 2012 John Wiley & Sons, Ltd.     

Evaluation of a robust, diimide-based, porous organic polymer (POP) as a high-capacity sorbent for representative chemical threats

A previously described porous organic polymer (NU-POP-1) was evaluated against four representative chemical threats: ammonia, cyanogen chloride, sulfur dioxide, and octane. Ammonia, cyanogen chloride, and sulfur dioxide are examples of toxic industrial chemicals (TICs) spanning the range from highly basic to strong-acid forming substances, while octane is used to assess physical adsorption capacity. Experiments were carried out using a microbreakthrough test apparatus, which measures the adsorption capacity at saturation and gives an indication of the strength of adsorption. The NU-POP-1 material exhibited substantial removal capabilities against the majority of the toxic chemicals, with capacities as high as or better than an activated, impregnated carbon. The ability to remove the highly volatile toxic chemicals ammonia and cyanogen chloride was intriguing, as these chemicals typically require reactive moieities for removal. The present work presents a benchmark for toxic chemical removal, and future work will focus on incorporating functional groups targeting the toxic chemicals of interest.     

Associations between evaporative cooling and dust‐mite allergens,endotoxins, and β‐(1 → 3)‐d‐glucans in house dust: A study of low‐income homes

Recent work suggests that evaporative coolers increase the level and diversity of bioaerosols, but this association remains understudied in low‐income homes. We conducted a cross‐sectional study of metropolitan, low‐income homes in Utah with evaporative coolers (n = 20) and central air conditioners (n = 28). Dust samples (N = 147) were collected from four locations in each home and analyzed for dust‐mite allergens Der p1 and Der f1, endotoxins, and β‐(1 → 3)‐d ‐glucans. In all sample locations combined, Der p1 or Der f1 was significantly higher in evaporative cooler versus central air conditioning homes (OR = 2.29, 95% CI = 1.05‐4.98). Endotoxin concentration was significantly higher in evaporative cooler versus central air conditioning homes in furniture (geometric mean (GM) = 8.05 vs 2.85 EU/mg, P < .01) and all samples combined (GM = 3.60 vs 1.29 EU/mg, P = .03). β‐(1 → 3)‐d ‐glucan concentration and surface loads were significantly higher in evaporative cooler versus central air conditioning homes in all four sample locations and all samples combined (P < .01). Our study suggests that low‐income, evaporative cooled homes have higher levels of immunologically important bioaerosols than central air‐conditioned homes in dry climates, warranting studies on health implications and other exposed populations.     

Hydrogel/bioactive glass composites for bone regeneration applications: Synthesis and characterisation

Due to the deficiencies of current commercially available biological bone grafts, alternative bone graft substitutes have come to the forefront of tissue engineering in recent times. The main challenge for scientists in manufacturing bone graft substitutes is to obtain a scaffold that has sufficient mechanical strength and bioactive properties to promote formation of new tissue. The ability to synthesise hydrogel based composite scaffolds using photopolymerisation has been demonstrated in this study. The prepared hydrogel based composites were characterised using techniques including Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectrometry (EDX), rheological studies and compression testing. In addition, gel fraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), porosity and swelling studies of the composites were carried out. It was found that these novel hydrogel bioglass composite formulations did not display the inherent brittleness that is typically associated with bioactive glass based bone graft materials and exhibited enhanced biomechanical properties compared to the polyethylene glycol hydrogel scaffolds along. Together, the combination of enhanced mechanical properties and the deposition of apatite on the surface of these hydrogel based composites make them an ideal candidate as bone graft substitutes in cancellous bone defects or low load bearing applications.