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801.
Jordi Guiteras Elena Crespo Pere Fontova Nuria Bolaos Montse Gom Esther Castao Oriol Bestard Josep M. Griny Joan Torras 《International journal of molecular sciences》2022,23(15)
Systemic lupus erythematosus is a complex autoimmune disorder mostly mediated by B-cells in which costimulatory signals are involved. This immune dysregulation can cause tissue damage and inflammation of the kidney, resulting in lupus nephritis and chronic renal failure. Given the previous experience reported with CTLA4-Ig as well as recent understanding of the PD-1 pathway in this setting, our group was encouraged to evaluate, in the NZBWF1 model, a human fusion recombinant protein (Hybri) with two domains: CTLA4, blocking the CD28—CD80 costimulatory pathway, and PD-L2, exacerbating the PD-1–PD-L2 coinhibitory pathway. After achieving good results in this model, we decided to validate the therapeutic effect of Hybri in the more severe MRL/lpr model of lupus nephritis. The intraperitoneal administration of Hybri prevented the progression of proteinuria and anti-dsDNA antibodies to levels like those of cyclophosphamide and reduced the histological score, infiltration of B-cells, T-cells, and macrophages and immune deposition in both lupus-prone models. Additionally, Hybri treatment produced changes in both inflammatory-related circulating cytokines and kidney gene expression. To summarize, both in vivo studies revealed that the Hybri effect on costimulatory-coinhibitory pathways may effectively mitigate lupus nephritis, with potential for use as a maintenance therapy. 相似文献
802.
803.
Jordi Vilaplana Francesc Solsona Ivan Teixidó Jordi Mateo Francesc Abella Josep Rius 《The Journal of supercomputing》2014,69(1):492-507
The ability to deliver guaranteed QoS (Quality of Service) is crucial for the commercial success of cloud platforms. This paper presents a model based on queuing theory to study computer service QoS in cloud computing. Cloud platforms are modeled with an open Jackson network that can be used to determine and measure the QoS guarantees the cloud can offer regarding the response time. The analysis can be performed according to different parameters, such as the arrival rate of customer services and the number and service rate of processing servers, among others. Detailed results for the model are presented. When scaling the system and depending on the types of bottleneck in the system, we show how our model can provide us with the best option to guarantee QoS. The results obtained confirm the usefulness of the model presented for designing real cloud computing systems. 相似文献
804.
José L. Balcázar Josep Díaz Ricard Gavaldà Osamu Watanabe 《New Generation Computing》1994,12(4):337-358
It is known that the class of deterministic finite automata is polynomial time learnable by using membership and equivalence queries. We investigate the query complexity of learning deterministic finite automata, i.e., the number of membership and equivalence queries made during the process of learning. We extend a known lower bound on membership queries to the case of randomized learning algorithms, and prove lower bounds on the number of alternations between membership and equivalence queries. We also show that a trade-off exists, allowing us to reduce the number of equivalence queries at the price of increasing the number of membership queries. 相似文献
805.
本文对孤立直流微电网动态特性进行了分析,并提出了改善策略.在孤网条件下,电压主要靠系统中基于储能的DC/DC变换器进行控制,因此多DC/DC变换器动态特性即可反应系统全局的动态特性.本文中各DC/DC变换器采用I-V下垂控制,并以负载的变化量为输入,变换器输出电流、占空比及母线电压为状态变量对多DC/DC变换器进行了大信号模型的建立.基于上述模型,本文对输出电流动态特性的影响因素进行了根轨迹分析,最后提出自适应P控制策略以提高直流微电网中的动态特性.最后通过仿真对提出的模型及控制策略进行了验证. 相似文献
806.
Belén Lerma-Berlanga Natalia M. Padial Marta Galbiati Isaac Brotons-Alcázar Josep Albero Hermenegildo García Alicia Forment-Aliaga Carolina R. Ganivet Carlos Martí-Gastaldo 《Advanced functional materials》2023,33(41):2302246
The presence of tetrazine units in the organic nodes of UiO-68-TZCD controls the formation of ultrathin coatings of single-wall nanotubes that decorate the surface of the crystal. These crystal hybrids can be prepared straightforwardly in one step and are extraordinarily respectful with the properties of the framework for combination of mesoporosity and surface areas ≈4.000 m2 g−1, with excellent stability in water, and conductivities at room temperature of 4 × 10−2 S cm−1 even at very low carbon weight contents (2.3 wt.%). 相似文献
807.
Sara Castro-Barquero Rosa Casas Eric B. Rimm Anna Tresserra-Rimbau Dora Romaguera J. Alfredo Martínez Jordi Salas-Salvadó Miguel A. Martínez-González Josep Vidal Miguel Ruiz-Canela Jadwiga Konieczna Emilio Sacanella Jesús Francisco García-Gavilán Montse Fitó Ana García-Arellano Ramon Estruch 《Molecular nutrition & food research》2023,67(4):2200264
808.
Ferran Pujol-Vila Pau Güell-Grau Josep Nogués Mar Alvarez Borja Sepúlveda 《Advanced functional materials》2023,33(14):2213109
Soft optomechanical systems have the ability to reversibly respond to optical and mechanical external stimuli by changing their own properties (e.g., shape, size, viscosity, stiffness, color or transmittance). These systems typically combine the optical properties of plasmonic, dielectric or carbon-based nanomaterials with the high elasticity and deformability of soft polymers, thus opening the path for the development of new mechanically tunable optical systems, sensors, and actuators for a wide range of applications. This review focuses on the recent progresses in soft optomechanical systems, which are here classified according to their applications and mechanisms of optomechanical response. The first part summarizes the soft optomechanical systems for mechanical sensing and optical modulation based on the variation of their optical response under external mechanical stimuli, thereby inducing mechanochromic or intensity modulation effects. The second part describes the soft optomechanical systems for the development of light induced mechanical actuators based on different actuation mechanisms, such as photothermal effects and phase transitions, among others. The final section provides a critical analysis of the main limitations of current soft optomechanical systems and the progress that is required for future devices. 相似文献
809.
Marija Vukomanović Lea Gazvoda Mario Kurtjak Marjeta Maček-Kržmanc Matjaž Spreitzer Qiao Tang Jiang Wu Hao Ye Xiangzhong Chen Michele Mattera Josep Puigmartí-Luis Salvador Vidal Pane 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(35):2301981
Poly-L-lactide (PLLA) offers a unique possibility for processing into biocompatible, biodegradable, and implantable piezoelectric structures. With such properties, PLLA has potential to be used as an advanced tool for mimicking biophysical processes that naturally occur during the self-repair of wounds and damaged tissues, including electrostimulated regeneration. The piezoelectricity of PLLA strongly depends on the possibility of controlling its crystallinity and molecular orientation. Here, it is shown that modifying PLLA with a small amount (1 wt%) of crystalline filler particles with a high aspect ratio, which act as nucleating agents during drawing-induced crystallization, promotes the formation of highly crystalline and oriented PLLA structures. This increases their piezoelectricity, and the filler-modified PLLA films provide a 20-fold larger voltage output than nonmodified PLLA during ultrasound (US)-assisted activation. With 99% PLLA content, the ability of the films to produce reactive oxygen species (ROS) and increase the local temperature during interactions with US is shown to be very low. US-assisted piezostimulation of adherent cells directly attach to their surface (such as skin keratinocytes), stimulate cytoskeleton formation, and as a result cells elongate and orient themselves in a specific direction that align with the direction of PLLA film drawing and PLLA dipole orientation. 相似文献
810.
The performance of radiosity algorithms has been improved in recent years by means of using coherence when evaluating the visibility function for form factor computation. We present here a brief characterization of the uses of coherence for this goal. The characterization includes both previously proposed techniques and unexplored ones. Afterwards we propose new uses of coherence for visibility computation in form factor determination and we discuss the results of its implementation. 相似文献