Involuntary contractions of the striated anal sphincters as a cause of constipation: report of a case

PURPOSE: To report a case of corneal ulcer associated with deposits of norfloxacin. METHOD: Case report. A 40-year-old man with right trigeminal and facial nerve palsies and decreased tear secretion developed a corneal ulcer with white deposits in the right eye. The deposits were removed and analyzed by high-performance liquid chromatography. RESULTS: High-performance liquid chromatography results disclosed that the deposits on the corneal surface had the same retention time as norfloxacin. The patient discontinued norfloxacin ophthalmic solution and recovered successfully. CONCLUSION: Clinicians should be aware that frequent applications of topical norfloxacin in patients with decreased tear secretion may result in deposition of the drug on the cornea.     

Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies

We have blocked creatine kinase (CK) mediated phosphocreatine (PCr) <==> ATP transphosphorylation in mitochondria and cytosol of skeletal muscle by knocking out the genes for the mitochondrial (ScCKmit) and the cytosolic (M-CK) CK isoforms in mice. Animals which carry single or double mutations, if kept and tested under standard laboratory conditions, have surprisingly mild changes in muscle physiology. Strenuous ex vivo conditions were necessary to reveal that MM-CK absence in single and double mutants leads to a partial loss of tetanic force output. Single ScCKmit deficiency has no noticeable effects but in combination the mutations cause slowing of the relaxation rate. Importantly, our studies revealed that there is metabolic and cytoarchitectural adaptation to CK defects in energy metabolism. The effects involve mutation type-dependent alterations in the levels of AMP, IMP, glycogen and phosphomonoesters, changes in activity of metabolic enzymes like AMP-deaminase, alterations in mitochondrial volume and contractile protein (MHC isoform) profiles, and a hyperproliferation of the terminal cysternae of the SR (in tubular aggregates). This suggests that there is a compensatory resiliency of loss-of-function and redirection of flux distributions in the metabolic network for cellular energy in our mutants.     

Impacts of a weir and power station on downstream migrating Atlantic salmon smolts in a German river

Weirs are barriers built across rivers for a wide range of other purposes than hydropower production. Like hydropower installations, weirs can negatively impact fish migrations. Downstream migration and mortality of Atlantic salmon smolts were studied during passage of a weir and power station by tagging 227 smolts with radio transmitters. Extra loss of smolts due to the weir and adjacent reservoir was 5.2%. Mortality was likely related to physical damage imposed to the smolts and/or increased predation risk. Extra loss of smolts did not differ between the weir and the power station (7.2%). Migration speeds were reduced at the power station but not at the weir. We conclude that mortality at one power station site may differ considerably among years, because the mortality was more than four times higher in a previous year than in this study. Increased river discharge seemed to decrease mortality and increase migration speeds at the power station.     

Social influence in a virtual tunnel fire – Influence of conflicting information on evacuation behavior

Evacuation from a smoke filled tunnel requires quick decision-making and swift action from the tunnel occupants. Technical installations such as emergency signage aim to guide tunnel occupants to the closest emergency exits. However, conflicting information may come from the behavior of other tunnel occupants. We examined if and how conflicting social information may affect evacuation in terms of delayed and/or inadequate evacuation decisions and behaviors. To this end, forty participants were repeatedly situated in a virtual reality smoke filled tunnel with an emergency exit visible to one side of the participants. Four social influence conditions were realized. In the control condition participants were alone in the tunnel, while in the other three experimental conditions a virtual agent (VA) was present. In the no-conflict condition, the VA moved to the emergency exit. In the active conflict condition, the VA moved in the opposite direction of the emergency exit. In the passive conflict condition, the VA stayed passive. Participants were less likely to move to the emergency exit in the conflict conditions compared to the no-conflict condition. Pre-movement and movement times in the passive conflict condition were significantly delayed compared to all other conditions. Participants moved the longest distances in the passive conflict condition. These results support the hypothesis that social influence affects evacuation behavior, especially passive behavior of others can thwart an evacuation to safety.