在靠近流浆箱处淀粉和填料同时混合工艺

采用闪急混合工艺使得在最接近流浆箱处向浆料中加入助留剂和施胶化学品等造纸添加剂,并使之迅速和有效地混合。这项多功能混合技术可以做到在同一地点同时将填料、助留剂一起加入到流浆箱中。该工艺操作简单,具有非常短的响应时间,填料留着率更高,纸张性能更优越。由于减少了添加剂在过程中的循环,响应时间非常快速,减少了传统混合过程的水或滤液的量,从而降低了能源消耗,降低了添加剂用量并使工艺过程净化。     

Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in isolated human hepatocytes. Based on the results obtained in vitro, three Phase 1 crossover pharmacokinetic studies were conducted in healthy postmenopausal women to assess the in vivo effects of ospemifene on CYP-mediated drug metabolism. Ospemifene and its main metabolites 4-hydroxyospemifene and 4′-hydroxyospemifene weakly inhibited a number of CYPs (CYP2B6, CYP2C9, CYP2C19, CYP2C8, and CYP2D6) in vitro. However, only CYP2C9 activity was inhibited by 4-hydroxyospemifene at clinically relevant concentrations. Induction of CYPs by ospemifene in cultured human hepatocytes was 2.4-fold or less. The in vivo studies showed that ospemifene did not have significant effects on the areas under the plasma concentration-time curves of the tested CYP substrates warfarin (CYP2C9), bupropion (CYP2B6) and omeprazole (CYP2C19), demonstrating that pretreatment with ospemifene did not alter their metabolism. Therefore, the risk that ospemifene will affect the pharmacokinetics of drugs that are substrates for CYP enzymes is low.     

Magnetic Concentration of Quartz Sand for Glass Industry

The authors consider the production experience of a separator of the new generation with constant magnets based on Nd – Fe – B, which was designed by ÉMKO Company for producing quartz glass concentrates of grades OVS-030 and OVS-025, using dry magnetic separation. The proposed separator has several advantages compared to electromagnetic separators of the EVS series, which have the same purpose.     

A representative and comprehensive review of the electrical and thermal properties of polymer composites with carbon nanotube and other nanoparticle fillers

In this review we present the results of our literature investigation into the electrical and thermal properties of carbon nanotube polymer composites. A short selection of data relating to conductive polymer composites with various fillers is provided for comparison. The effects of filler properties such as type and size, the use of hybrid fillers, fabrication methods for polymer composites and the importance of the modeling of the electronic and thermal transport mechanisms are discussed, as are more general factors influencing the properties of these composites. This review represents a comprehensive survey and constructive study and should serve as a useful reference tool for industrial and academic researchers working in this field. © 2017 Society of Chemical Industry     

Water hydraulic manipulator for fail safe and fault tolerant remote handling operations at ITER

Department of Intelligent Hydraulics and Automation (IHA) of Tampere University of Technology has been involved in the European Fusion program since 1994 within the ITER reactor maintenance activities. In this paper we discuss the design and development of a six degrees of freedom water hydraulic manipulator with a force feedback for teleoperation tasks. The manipulator is planned to be delivered to Divertor Test Platform 2 (DTP2) during year 2008. The paper also discusses the possibility to improve the fail safe and redundant operation of the manipulator. During the design of the water hydraulic manipulator, special provisions have been made in order to meet the safety requirements such as servo valve block for redundant operation and safety vane brakes for fail safe operation.     

A framework for generating tunable test functions for multimodal optimization

Multimodal function optimization, where the aim is to locate more than one solution, has attracted growing interest especially in the evolutionary computing research community. To evaluate experimentally the strengths and weaknesses of multimodal optimization algorithms, it is important to use test functions representing different characteristics and various levels of difficulty. The available selection of multimodal test problems is, however, rather limited and no general framework exists. This paper describes an attempt to construct a software framework which includes a variety of easily tunable test functions. The aim is to provide a general and easily expandable environment for testing different methods of multimodal optimization. Several function families with different characteristics are included. The framework implements new parameterizable function families for generating desired landscapes. Additionally the framework implements a selection of well known test functions from the literature, which can be rotated and stretched. The software module can easily be imported to any optimization algorithm implementation compatible with the C programming language. As an application example, 8 optimization approaches are compared by their ability to locate several global optima over a set of 16 functions with different properties generated by the proposed module. The effects of function regularity, dimensionality and number of local optima on the performance of different algorithms are studied.     

Risk assessment of a timber frame building by using CRISP simulation

The fire risk assessment model CRISP2 was applied to a 4‐storey apartment building. The case building was an actual 4‐storey timber‐framed building. Partly predetermined design alternatives were used in sequential simulations. CRISP2 cannot take into account the frame‐material of the building in a satisfactory way, because the wall thickness, structural fire resistance or lining materials in the fire room cannot be modelled. It was found that adding smoke alarms almost halved the risk level. The risk levels 1–2×10^?5 obtained are not far from comparable levels of fire death statistics from Finland, the United Kingdom, Sweden and Norway. Copyright © 2002 John Wiley & Sons, Ltd.     

Mapping of snow water equivalent and snow depth in boreal and sub-arctic zones by assimilating space-borne microwave radiometer data and ground-based observations

The monitoring of snow water equivalent (SWE) and snow depth (SD) in boreal forests is investigated by applying space-borne microwave radiometer data and synoptic snow depth observations. A novel assimilation technique based on (forward) modelling of observed brightness temperatures as a function of snow pack characteristics is introduced. The assimilation technique is a Bayesian approach that weighs the space-borne data and the reference field on SD interpolated from discrete synoptic observations with their estimated statistical accuracy. The results obtained using SSM/I and AMSR-E data for northern Eurasia and Finland indicate that the employment of space-borne data using the assimilation technique improves the SD and SWE retrieval accuracy when compared with the use of values interpolated from synoptic observations. Moreover, the assimilation technique is shown to reduce systematic SWE/SD estimation errors evident in the inversion of space-borne radiometer data.     

Gaschromatographie des Isopropanol-?thanol-Methanol-Wassersystems

Zusammenfassung Zum Nachweis von Isopropanol bei gleichzeitiger Anwesenheit von Methanol, Äthanol und Wasser wurde eine gaschromatographische Methode entwickelt. Die für diesen Zweck günstige Gesamtlänge der Kolonne beträgt 2,84 m, wovon der 2,24 m lange Anfangsteil mit Paraffinphase und der 0,6 m lange Schlußteil mit Polyäthylenglykolphase gefüllt ist. Als empfehlenswerte Temperatur für die Chromatographierung wird 47° C angegeben, wobei die Retentionszeiten für Methanol 12,1 min, für Äthanol 20,0 min, für Isopropanol 25,0 min und für Wasser 36 min betragen. Die Methode eignet sich ebenfalls gut zur quantitativen Bestimmung kleiner Äthanolmengen (1–3 Gew.-%) in Isopropanol.     

Development of LC/MS/MS methods for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrospray ionization

Good reliability of Caco-2 permeability studies requires competent sampling and analytical methods to ensure the comparability of day-to-day experiments. In this work, two n-in-one LC/MS/MS methods based on two different ionization techniques were developed and validated for a group of reference compounds; eight of them are recommended by the Food and Drug Administration (FDA) for the evaluation of oral drug permeability. The performance of a new ionization technique, atmospheric pressure photoionization (APPI), as an interface for quantitative LC/MS analysis was evaluated in comparison to the electrospray ionization (ESI). Generally, the validation parameters, including sensitivity, accuracy, and repeatability, were comparable for the APPI and ESI methods. The main difference was that the linear quantitative range of APPI was 3-4 orders of magnitude (r(2) >/= 0.998) whereas in ESI it was typically 2-3 orders of magnitude (r(2) >/= 0.990). By the APPI and ESI methods, the simultaneous analysis of nine highly heterogeneous compounds was achieved within 5.5-7 min, which leads to significant savings in time and cost of the analyses. The successful validation data indicate the usefulness of both the methods for the rapid and sensitive (LOD values typically 相似文献