Applications of fuzzy‐based linguistic patterns for the assessment of computer screen design quality

The main objective of this study was to develop a modeling framework which would unify different aspects of computer screen design and result in a quantitative criterion for an optimized computer screen format. The fuzzy set‐based linguistic design patterns were utilized as a tool to build this model. The linguistic patterns are based on categories of expressions related closely to natural language and truth values, which are close to a human designer's intuition. The proposed framework is capable of assessing the quality of computer screen design based on existing knowledge in human‐computer interface domain using the fuzzy‐based linguistic pattern approach. Exemplary patterns for an optimal screen density, information grouping, and some aspects of screen layout are presented, along with a sequence of calculations based on the exemplary screen format. This study showed that it is possible to achieve a rational and relatively easy to interpret assessment of different screen designs in the form of the degrees of truth. Such an evaluation criterion reflects the compatibility of a given screen design with the optimal one based on the current knowledge in the field. It is believed that the proposed methodological framework for computer screen design should significantly augment the efforts of human designers.     

Reproducibility of MRI-based white matter tract estimation using multi-fiber probabilistic tractography: effect of user-defined parameters and regions

Objective

There is a pressing need to assess user-dependent reproducibility of multi-fibre probabilistic tractography in order to encourage clinical implementation of these advanced and relevant approaches. The goal of this study was to evaluate both intrinsic and inter-user reproducibility of corticospinal tract estimation.

Materials and methods

Six clinical datasets including motor functional and diffusion MRI were used. Three users performed an independent tractography analysis following identical instructions. Dice indices were calculated to quantify the reproducibility of seed region, fMRI-based end region, and streamline maps.

Results

The inter-user reproducibility ranged 41–93%, 29–94%, and 50–92%, for seed regions, end regions, and streamline maps, respectively. Differences in streamline maps correlated with differences in seed and end regions. Good inter-user agreement in seed and end regions, yielded inter-user reproducibility close to the intrinsic reproducibility (92–97%) and in most cases higher than 80%.

Discussion

Uncertainties related to user-dependent decisions and the probabilistic nature of the analysis should be considered when interpreting probabilistic tractography data. The standardization of the methods used to define seed and end regions is a necessary step to improve the accuracy and robustness of multi-fiber probabilistic tractography in a clinical setting. Clinical users should choose a feasible compromise between reproducibility and analysis duration.

     

Novel 1,3,5-Triazinyl Aminobenzenesulfonamides Incorporating Aminoalcohol,Aminochalcone and Aminostilbene Structural Motifs as Potent Anti-VRE Agents,and Carbonic Anhydrases I,II, VII,IX, and XII Inhibitors

A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs was synthesized as potential human carbonic anhydrase (hCA) inhibitors. The compounds were evaluated on their inhibition of tumor-associated hCA IX and hCA XII, hCA VII isoenzyme present in the brain, and physiologically important hCA I and hCA II. While the test compounds had only a negligible effect on physiologically important isoenzymes, many of the studied compounds significantly affected the hCA IX isoenzyme. Several compounds showed activity against hCA XII; (E)-4-{2-[(4-[(2,3-dihydroxypropyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (31) and (E)-4-{2-[(4-[(4-hydroxyphenyl)amino]-6-[(4-styrylphenyl)amino]-1,3,5-triazin-2-yl)amino]ethyl}benzenesulfonamide (32) were the most effective inhibitors with K_Is = 4.4 and 5.9 nM, respectively. In addition, the compounds were tested against vancomycin-resistant Enterococcus faecalis (VRE) isolates. (E)-4-[2-({4-[(4-cinnamoylphenyl)amino]-6-[(4-hydroxyphenyl)amino]-1,3,5-triazin-2-yl}amino)ethyl]benzenesulfonamide (21) (MIC = 26.33 µM) and derivative 32 (MIC range 13.80–55.20 µM) demonstrated the highest activity against all tested strains. The most active compounds were evaluated for their cytotoxicity against the Human Colorectal Tumor Cell Line (HCT116 p53 +/+). Only 4,4’-[(6-chloro-1,3,5-triazin-2,4-diyl)bis(iminomethylene)]dibenzenesulfonamide (7) and compound 32 demonstrated an IC₅₀ of ca. 6.5 μM; otherwise, the other selected derivatives did not show toxicity at concentrations up to 50 µM. The molecular modeling and docking of active compounds into various hCA isoenzymes, including bacterial carbonic anhydrase, specifically α-CA present in VRE, was performed to try to outline a possible mechanism of selective anti-VRE activity.     

Studies in Carbohydrate Based Glues and Thickeners for Foodstuffs. Part I: Glucose - Sucrose - Apple Pectin Ternary System

Viscosities are given of aqueous solutions of α-D-glucose, sucrose, apple pectin and Arabic gum, as well as of various binary mixtures of these solutions. Aqueous mixtures of α-D-glucose and sucrose exhibit a small increase in viscosity. The addition of apple pectin to the binary mixtures gives solutions of a viscosity of Arabic gum.     

Erythritol,a New Raw Material for Food and Non-food Applications

In response to an increasing demand from consumers for healthier and calorie controlled foods, Cerestar has developed a new food ingredient, erythritol. Erythritol can be produced from starch by a full biotechnological process, combining enzymatic and fermentative conversions. The use of an osmophilic yeast allows the fermentation step to be performed at high dry substance, giving an economic advantage. An extremely pure end product is then easily obtained by final crystallisation. Erythritol is structurally a polyol and shares the health properties of other polyols such as being toothfriendly and safe for diabetics. However, it offers in addition two very important nutritional advantages: a lower calorific value (0.3 Kcal/g) and a good tolerance. This is due to its low molecular weight, which allows erythritol to be rapidly absorbed from the small intestine, with subsequent excretion in the urine. Fermentation in the colon is therefore excluded and any resulting gastro-intestinal discomfort avoided. The combination of these properties makes erythritol a unique low calorie bulk sweetener. From a functionality point of view, erythritol is a moderately sweet bulking agent with a cooling taste: workability is similar to other polyols. It has a taste profile close to that of sucrose and may therefore improve the taste quality of a blend with intense sweeteners. Its low solubility and ease of crystallisation, make erythritol very suitable for applications which require a crystalline sweetener, such as chocolate. Other potential application areas are bakery, table-top and confectionery. Presently erythritol is under evaluation to establish beyond any doubt its safety and to obtain food approval as a new, low calorie, bulk sweetener. Potential non-food applications of erythritol are in polymers, fine chemicals and pharmaceutical intermediates.     

The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment

This study investigates the effect of Dexamethasone (Dex) treatment on blood and skeletal muscle metabolites level and skeletal muscle activity of enzymes related to energy metabolism after long-duration swimming. To evaluate whether Dex treatment, swimming, and combining these factors act on analyzed data, rats were randomly divided into four groups: saline treatment non-exercise and exercise and Dex treatment non-exercised and exercised. Animals in both exercised groups underwent long-lasting swimming. The concentration of lipids metabolites, glucose, and lactate were measured in skeletal muscles and blood according to standard colorimetric and fluorimetric methods. Also, activities of enzymes related to aerobic and anaerobic metabolism were measured in skeletal muscles. The results indicated that Dex treatment induced body mass loss and increased lipid metabolites in the rats’ blood but did not alter these changes in skeletal muscles. Interestingly, prolonged swimming applied after 9 days of Dex treatment significantly intensified changes induced by Dex; however, there was no difference in skeletal muscle enzymatic activities. This study shows for the first time the cumulative effect of exercise and Dex on selected elements of lipid metabolism, which seems to be essential for the patient’s health due to the common use of glucocorticoids like Dex.     

Classifying the risk of work related low back disorders due to manual material handling tasks

Work related low back disorders (LBDs) due to manual lifting tasks (MLTs) have long been recognized as one of the main occupational disabling injury that affects the quality of life of the industrial working population in the U.S. There have been a number of intensive research efforts devoted to understanding the phenomena of LBDs and building classification models that could effectively distinguish between high risk and low risk MLTs that contribute to LBDs. As of today, however, such models and the occupational exposure limits of different risk factors causing LBDs as well as the guidelines preventing them have not yet been fully proposed. One of the first efforts to comprehend the nature and phenomenon of LBDs was undertaken by Marras et al. (1993). They created a seminal data set and used it to build logistic regression (LR) models to identify significant variables and classify MLTs into high risk and low risk with respect to LBDs. Since then a number of studies have used the same data set to build and test various classifiers to detect the likelihood of LBDs due to manual material handling jobs. This paper summarizes and critiques the previous studies. It also employs this data set to build and test seven classification models, two of which have not been applied in this context yet. The parameters of the models have been calibrated for the best performance, and the models were constructed and validated on the full set and the reduced set of features. Though the performances of our best models are better than those reported in National Institute for Occupational Health and Safety (NIOHS) Guides and two of our previous studies, they are generally less optimistic than those reported in several other studies; this paper proposes a systematic and more reliable approach to creating and validating classifiers to distinguish between low and high risk MLTs that contribute to LBDs.     

The location of a resistive shunt harmonic impedance along a distribution feeder and its influence on harmonic propagation

Although complete compensation is only possible using true active filters, resistive shunt harmonic impedances (SHI) have been shown to provide a considerable reduction of the harmonic propagation. In this paper, the harmonic mitigation potential of a resistive SHI is discussed concerning its influence on the voltage distortion profile along a typical distribution feeder, with the location of the SHI along the feeder as a parameter. Although the distortion values are dependent on the SHI location, it is shown that the end of the feeder is generally a good location to install the SHI, especially when the power system parameters can vary or are unknown. Calculations are performed on a typical radial distribution feeder. Both the power factor correction capacitors and the non-linear loads are concentrated in single nodes. The linear loads are disconnected to obtain the worst case for the voltage distortion. Also some measurements on a scale model of a typical distribution feeder are done and the experimental results confirm the results obtained from simulations.     

e-R&D – Effectively Managing Process Diversity

Managing process diversity becomes increasingly relevant in software development. Software organizations typically do not work on the greenfield and thus need to integrate external workflows with R&;D internal workflow management and heterogeneous development and maintenance processes. To stay competitive with its software development, Alcatel has put in place an orchestrated improvement program of its processes and the underlying engineering tools environment. Why do we call this “e-R&;D”? For two reasons. These improvement activities necessarily fit into the wider context of Alcatel's business process improvement and corporate e-business initiatives. The “e-R&;D” also means enabling of interactive R&;D processes and increasing collaborative work across the globe. At Alcatel we realized, during a substantial reengineering of our development and industrialization processes, that the approach to acquire an off-the-shelf process and tailor it to our needs was not applicable. Different processes need to be seamlessly integrated to avoid inconsistencies and inefficiency caused by replicated work. Specific focus is given within this article on how we manage process diversity in a product line where various components are embedded in individual architectures, asking for different but defined development and maintenance processes depending on pre-selected criteria.