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921.
922.
Chengli Wang Zhiwei Fang Ailun Yi Bingcheng Yang Zhe Wang Liping Zhou Chen Shen Yifan Zhu Yuan Zhou Rui Bao Zhongxu Li Yang Chen Kai Huang Jiaxiang Zhang Ya Cheng Xin Ou 《光:科学与应用(英文版)》2021,(8):1474-1484
The realization of high-quality (Q) resonators regardless of the underpinning material platforms has been a ceaseless pursuit, because the high-Q resonators pro... 相似文献
923.
Chunxia Qiao Ming Lv Xinying Li Xiaoling Lang Shouqin Lv Mian Long Yan Li Shusheng Geng Zhou Lin Beifen Shen Jiannan Feng 《工程(英文)》2021,7(11):1566-1576
Fully human antibodies have minimal immunogenicity and safety profiles. At present, most potential antibody drugs in clinical trials are humanized or fully human. Human antibodies are mostly generated using the phage display method (in vitro) or by transgenic mice (in vivo); other methods include B lymphocyte immortalization, human–human hybridoma, and single-cell polymerase chain reaction. Here, we describe a structure-based computer-aided de novo design technology for human antibody generation. Based on the complex structure of human epidermal growth factor receptor 2 (HER2)/Herceptin, we first designed six short peptides targeting the potential epitope of HER2 recognized by Herceptin. Next, these peptides were set as complementarity determining regions in a suitable immunoglobulin frame, giving birth to a novel anti-HER2 antibody named “HF,” which possessed higher affinity and more effective anti-tumor activity than Herceptin. Our work offers a useful tool for the quick design and selection of novel human antibodies for basic mechanical research as well as for imaging and clinical applications in immune-related diseases, such as cancer and infectious diseases. 相似文献
924.
Tianhao Wu Zhenzhen Qin Yanbo Wang Yongzhen Wu Wei Chen Shufang Zhang Molang Cai Songyuan Dai Jing Zhang Jian Liu Zhongmin Zhou Xiao Liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding Zhijun Ning Yabing Qi Yiqiang Zhang Liyuan Han 《纳微快报(英文)》2021,(10):113-130
Perovskite solar cells (PSCs) emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from ... 相似文献
925.
Automated rangeland vegetation cover and density estimation using ground digital images and a spectral-contextual classifier 总被引:2,自引:0,他引:2
A method to estimate vegetation cover, density and background brightness parameters in a rangeland environment from low-altitude digital images is presented. A digital still-frame camera, mounted on a 5.2 m pole, is used to acquire images of the ground. The acquired images are then processed using an unsupervised spectral-contextual classifier to extract quantitative measurements automatically. The test results show that the extracted cover measures from the fully automated procedure provide an accuracy of 0.89 to 0.99, measured in kappa, compared with 0.36 to 0.58 and 0.79 to 0.95 from k -means clustering and maximum likelihood supervised classifications respectively. For the clump density measure, the proposed method had an error level ranging from 0 to -62%-hundreds of times less than those produced from both k -means and maximum likelihood classifications. The presented method overcomes human subjectivity inherent in other commonly used ground investigation methods for estimating vegetation cover. The results provide an accurate and objective reference for the calibration of models which relate the spectral reflectance recorded by remote sensors to quantitative measures of range condition. 相似文献
926.
927.
不规则钢筋砼板的塑性理论计算 总被引:1,自引:0,他引:1
不规则钢筋砼板的计算,目前尚无明确的方法和统一的计算结果。本探讨不规则的钢筋砼板在极限状态下承载能力的计算方法。用屈服线分析法求板的承载能力的数值解,对角部效应的影响提出了补偿内力功的概念,采用局部配置板顶钢盘的方法。 相似文献
928.
提出了一种新型单级Buck-Boost光伏逆变器的拓扑结构。该拓扑只需要五个功率开关和两个电力二极管,结构简单紧凑,无需直流分裂电容,开关频率低,通过占空比的调节,能在一个功率级内产生幅值高于或低于输入直流电压的交流电压,适用于AC模块。详细分析了所提逆变器的工作原理,并利用状态空间平均法建立了系统数学模型。利用串联谐振环节能实现所有开关的零电流开通和辅助开关的零电流关断,减小了开关损耗,提高了系统效率。采用SPWM控制方法,在Matlab/Simulink环境下建立了控制系统的仿真模型。仿真结果验证了该变换器的优点和SPWM控制方法的有效性。 相似文献
929.
930.
Ideas, hopes, and disappointments related to a quarter-century research into the laws of power industry development and its relations with society are reviewed; new hypotheses concerning the character and characteristics of these relations are formulated, and some preliminary results of the quantitative verification of these hypotheses are presented. The scope of future investigations is outlined and difficulties encountered in the attempts to collect the necessary retrospective information are considered. 相似文献