The Web and social networks

The sheer volume of Web data, together with its low signal-to-noise ratio, make it difficult for text-based search engines to locate high-quality pages. Analyzing the links between Web sites has dramatically improved the Web search experience and spawned research into the Web's link structure. This research includes graph-theoretic studies of connectivity, which have shown the Web to have strong similarities with social networks. Self-similarity is pervasive in social networks. While researchers have observed Web self-similarity in other contexts, finding a fractal structure in a graph theoretic setting adds further evidence to the Web's small-world social nature. Thus, researchers seek to explain and exploit the human behavior implicit in the Web's evolving structure. How can we combine the power of Web networks with networks resulting from other human activity? Accomplishing this goal represents knowledge management's key challenge and opportunity.     

Communicating violence risk assessments.

This Current Issues section of the American Psychologist examines recent advances in violence risk assessment, especially communications about risks of violence. Assessments of violence risk are required of most clinical psychologists. As research on violence begins to make possible more reliable estimates of risk, clinicians must have ways to use and communicate that information effectively. The three articles in this section identify and explore how we can begin to meet this challenge. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On the Bursty Evolution of Blogspace

We propose two new tools to address the evolution of hyperlinked corpora. First, we define time graphs to extend the traditional notion of an evolving directed graph, capturing link creation as a point phenomenon in time. Second, we develop definitions and algorithms for time-dense community tracking, to crystallize the notion of community evolution. We develop these tools in the context of Blogspace, the space of weblogs (or blogs). Our study involves approximately 750 K links among 25 K blogs. We create a time graph on these blogs by an automatic analysis of their internal time stamps. We then study the evolution of connected component structure and microscopic community structure in this time graph. We show that Blogspace underwent a transition behavior around the end of 2001, and has been rapidly expanding, not just in metrics of scale but also in metrics of community structure and connectedness. By randomizing link destinations in Blogspace, but retaining sources and timestamps, we introduce a concept of randomized Blogspace. Herein, we observe similar evolution of a giant component, but no corresponding increase in community structure. Having demonstrated the formation of micro-communities over time, we then turn to the ongoing activity within active communities. We extend recent work of Kleinberg (2002) to discover dense periods of bursty intra-community link creation. Furthermore, we find that the blogs that give rise to these communities are significantly more enduring than an average blog. An extended abstract of this paper appeared in the 12th International World Wide Web Conference, 2003.     

Quantitative thin-layer chromatography/mass spectrometry analysis of caffeine using a surface sampling probe electrospray ionization tandem mass spectrometry system

Quantitative determination of caffeine on reversed-phase C8 thin-layer chromatography plates using a surface sampling electrospray ionization system with tandem mass spectrometry detection is reported. The thin-layer chromatography/electrospray tandem mass spectrometry method employed a deuterium-labeled caffeine internal standard and selected reaction monitoring detection. Up to nine parallel caffeine bands on a single plate were sampled in a single surface scanning experiment requiring 35 min at a surface scan rate of 44 mum/s. A reversed-phase HPLC/UV caffeine assay was developed in parallel to assess the mass spectrometry method performance. Limits of detection for the HPLC/UV and thin-layer chromatography/electrospray tandem mass spectrometry methods determined from the calibration curve statistics were 0.20 ng injected (0.50 muL) and 1.0 ng spotted on the plate, respectively. Spike recoveries with standards and real samples ranged between 97 and 106% for both methods. The caffeine content of three diet soft drinks (Diet Coke, Diet Cherry Coke, Diet Pepsi) and three diet sport drinks (Diet Turbo Tea, Speed Stack Grape, Speed Stack Fruit Punch) was measured. The HPLC/UV and mass spectrometry determinations were in general agreement, and these values were consistent with the quoted values for two of the three diet colas. In the case of Diet Cherry Coke and the diet sports drinks, the determined caffeine amounts using both methods were consistently higher (by approximately 8% or more) than the literature values.     

Street children in Latin America

Worldwide, millions of children live on the streets. These children typically have access to neither health care nor education. Sometimes subjected to violence in the home before taking to the street, street children are seen by many as worthless, and many countries have used violent and punitive measures to eliminate them. New approaches have recently been implemented to return these children to society and their families. In the case of South America, children who are on the street are home-based and spend much of the day on the street, but have some family support and usually return home at night. Children of the street are street-based children who spend most days and nights on the street and are functionally without family support. Studies suggest that 80-90% of street children in Latin America have some contact with their families. Surveys also indicate that street children in Latin America are 8-17 years old, with 9 years old being the average age upon entering the street. Girls comprise 10-15% of street children and Black and mixed race children may be over-represented among street children in the region. Both published and unpublished research findings are used to shed light upon the status of street children in South America. The authors consider how many street children there may be, why there are street children, the problems they encounter, and what can be done to help them.     

CNS tissue Cu/Zn superoxide dismutase (SOD1) mutations in motor neurone disease (MND)

DNA extracted from CNS tissue of 79 cases of motor neurone disease (MND) was screened by single strand conformation analysis (SSCA) and heteroduplex analysis (HA) for mutations in the Cu/Zn superoxide dismutase (SOD1) gene. The aims were to determine whether somatic mutations of SOD1 may underlie some cases of MND and to characterize the genetic abnormalities by sequencing, for subsequent correlation with the molecular pathological phenotype. In 3 cases a point mutation was found in exon 4: E100G in one familial case, and I113T in two cases (one familial, one sporadic). Two cases had previously undescribed mutations in the 3' untranslated region (3'UTR) of SOD1 and one case had a single base substitution in the intronic sequence upstream from exon 2. None of these patients had a positive family history. Non-CNS tissue was available for 3 out of the 6 cases in whom changes were found. In all 3 the same changes were consistently found in both CNS and non-CNS tissue, excluding the presence of somatic mutations in SOD1. We investigated many MND blood samples and normal controls for the presence of the 3'UTR deletions. We found the 4 bp deletion in 1/90 sporadic MND patients and 1/209 non-MND controls. If the 3'UTR deletions are pathogenic, they would have to operate via a loss of the function mechanism, and further work is necessary to define their significance.     

Facilitatory effect of thinking about movement on magnetic motor-evoked potentials

BACKGROUND: The plasma level of endothelin-1 is locally increased during cooling but the net vasoconstrictor effect will be dependent on temperature effects on the vascular smooth muscle reactivity in response to the polypeptide. The aim of this study was to investigate the effect of cooling on the vascular smooth muscle response to endothelin-1 in human and rat veins. METHODS: Registration of vascular smooth muscle activity in vitro in vessel preparations from normal subjects. SETTING: Laboratory. PATIENTS AND ANIMALS: Superficial hand veins from 14 patients undergoing hand surgery and external jugular veins from 14 rats. INTERVENTIONS: Effects of endothelin-1, after denudation of the endothelium and during cooling, were compared with controls without these interventions. RESULTS: At 37 degrees C, endothelin-1 induced a concentration-dependent contraction in the human hand and rat jugular veins. The sensitivity to endothelin-1 was enhanced in segments without endothelium. At 37 degrees C, no relaxation in response to endothelin-1 was observed. Cooling to 10 degrees C did not alter precontraction achieved by endothelin-1 at 37 degrees C in the human hand veins, while it depressed the precontraction in the rat jugular vein. The effect of cold was reversible. Removal of the endothelium did not alter the response to cooling. CONCLUSIONS: The maintained reactivity in response to endothelin-1 during cooling of the human vessels suggests that the reported increase in endothelin-1 levels due to local cooling could contribute in the pathophysiology of peripheral vasospasm in humans.     

A case for automated large-scale semantic annotation

This paper describes Seeker, a platform for large-scale text analytics, and SemTag, an application written on the platform to perform automated semantic tagging of large corpora. We apply SemTag to a collection of approximately 264 million web pages, and generate approximately 434 million automatically disambiguated semantic tags, published to the web as a label bureau providing metadata regarding the 434 million annotations. To our knowledge, this is the largest scale semantic tagging effort to date.We describe the Seeker platform, discuss the architecture of the SemTag application, describe a new disambiguation algorithm specialized to support ontological disambiguation of large-scale data, evaluate the algorithm, and present our final results with information about acquiring and making use of the semantic tags. We argue that automated large-scale semantic tagging of ambiguous content can bootstrap and accelerate the creation of the semantic web.     

The development of structural integrity criteria for austenitic components

The high ductility and resistance to tearing of austenitic stainless steels, allied to the geometry and loading conditions of the European fast reactor (EFR), result in the prediction of large critical through-thickness crack sizes for EFR components. Based on this understanding of large critical crack sizes, simplified methods have been developed for the assessment of the leak-before-break behaviour of these components. The methods described avoid the need for detailed analysis of crack shape development during cyclic loading, and thus greatly reduce the calculational requirements compared with more common methods used for the assessment of known or postulated defects in high energy pressurised components. Simplifications used in the assessment of leak-tightness in EFR components are also identified.