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排序方式: 共有488条查询结果,搜索用时 31 毫秒
71.
Dr.-Ing. Dierk Raabe Dr.-Ing. Martin Hölscher Dr.-Ing. Mathias Dubke Dipl.-Ing. Karl-Heinz Hanke Dr.-Ing. Herbert Pfeifer Professor Dr. rer. nat. Dr. h.c. Kurt Lücke 《国际钢铁研究》1993,64(7):359-363
The textures and the mechanical properties of a strip cast, cold rolled and recrystallized ferritic stainless steel with 16% Cr have been investigated and compared to conventionally processed hot band. The strip cast initial material exposed three improvements. First, the textures were weaker and more homogeneous through the sheet thickness. Second, it revealed a higher Lankfort value and third, the complete elimination of the ridging phenomenon. 相似文献
72.
For some years a lot of effort has been put into improving the human-computer interface in CAD-systems. After a short introduction on input problems in design processes, some of this work is reported here as well as a fairly new method, handsketching. In the third part of this paper a special system called CASUS is thoroughly explained from the user's point of view. A fourth part deals with the authors' conviction that psychological theories and methods are necessary in order to create still better interfaces. In the last chapter the system presented with all its interface features is compared to some human factor considerations discussed before. No attention is paid to the fact that very often the quality of work is changed by introducing CAD-systems. Though the designer's situation can be very often improved much more by designing his entire work, this paper lays claim only to designing a tool for the designer's hand. 相似文献
73.
Die Löslichkeit von Tellur in Eisen wurde durch licht- und elektronenmikroskopische Prüfung von Fe–Te-Legierungen auf Ausscheidungen bestimmt. In α-Eisen bei 700°C sind etwa 50 ppm und bei 850°C 120 ppm löslich, in γ-Eisen lösen sich bei 930°C 5 ppm und bei 1000°C 22 ppm Te. Bei höheren Konzentrationen wird FeTe0,9 festgestellt. In Fe–Mn–Te-Legierungen wird das Te als Mangantellurid gebunden, dieses bildet Einschlüsse gemeinsam mit Mangansulfid. In Fe–Ti–Te-Legierungen wird nur ein kleiner Anteil Te in Titansulfiden gelöst. Tellur segregiert an die Korngrenzen von α- und γ-Eisen und bewirkt interkristallinen Bruch. Die mit AES bestimmten Korngrenzenkonzentrationen nehmen mit der Lösungskonzentration zu und erreichen bei Überschreiten der Löslichkeit einen Sättigungswert. Die Korngrenzensegregation nimmt mit zunehmender Temperatur ab. Tellur bewirkt eine auffallende Facettierung der Korngrenzflächen, es entstehen Strukturen mit Terrassen und Stufen. Die Proben brechen hierdurch bereits während der Auslagerung an den Korngrenzen auf und zeigen Kornzerfall. In Mn-haltigen Proben wird keine Korngrenzensegregation des Te beobachtet, wenn das Tellur völlig vom Mangan abgebunden ist; in diesem Fall ist der interkristalline Anteil der Bruchflächen sehr gering. Die chemische Bestimmung von Tellur in Eisen und Stählen kann sehr vorteilhaft mit der Atomabsorptionsspektroskopie durchgeführt werden, es wurden die Flammen- und die Graphitrohrmethode untersucht. Die Bestimmung kleiner Tellurgehalte in Stählen durch Atomisieren im Graphitrohr wird durch Chlorid, Chrom, Mangan und Nickel beeinflußt. Zu einer deutlichen Optimierung des Atomisierungsablaufs führt das Atomisieren von einer in das Graphitrohr eingeführten Plattform. Lediglich Mangan vermindert dann die Intensität des Absorptionssignals. Es wird eine Nachweisgrenze von 0,2 ppm Tellur bei einer relativen Standardabweichung von 30% erreicht. Mit der Flammentechnik gelingt die Bestimmung bis zu 50 ppm Tellur. 相似文献
74.
75.
Christoph Treskatis Peter Volgnandt Heimo Wessollek Päivi Puronpää-Schäfer Susanne Gerbl-Rieger Karl-Heinz Blank 《Grundwasser》1998,3(3):117-128
Long-term well efficiency is affected by increased approach velocity and turbulence due to reduced screen slot size and porosity in the gravel pack. Using preventive maintenance for well rehabilitation is an essential guard against the development of non-soluble incrustations of Fe- and Mn-(hydr)oxides. Anorganic acids destroy the microorganisms participated in well clogging and control mineral recrystallization. Minerals such as Fe-(hydr)oxides, Siderite or Calcite reduce the effective storage of the gravel pack and result in an inefficient well. Organic acids used in combination with ligands dissolve consolidated compounds by creating a new source of nutrients for germination. Surveillance of well efficiency and changes of drawdown can help to reduce the effort of chemicals for well rehabilitation. Using surging by back wash procedures or high-velocity, horizontal jetting techniques at an early stage of biochemical development aid to keep well efficiency at a high level. 相似文献
76.
PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy 总被引:4,自引:0,他引:4
Hess-Stumpp H Haberey M Thierauch KH 《Chembiochem : a European journal of chemical biology》2005,6(3):550-557
The angiogenesis inhibitor PTK 787/ZK 222584 (PTK/ZK) blocks all known VEGF receptor (VEGFR) tyrosine kinases, including the lymphangiogenic VEGFR3, in the lower nanomolar range. From a panel of 100 kinases only PDGFR, c-kit, and c-fms are inhibited beyond those in the nanomolar range. PTK/ZK functions as a competitive inhibitor at the ATP-binding site of the receptor kinase as shown here in kinetic experiments. The VEGF signal blockade in microvascular endothelial cells (MVEC) results in a blockade of MVEC proliferation (IC50=30 nM), without affecting the proliferation of normal tissue cells and tumor cells. The efficacy of PTK/ZK depends on its continuous presence within the endothelial target cells. Early removal attenuates its antiproliferative activity in vitro. Growth inhibition of endothelial cells is fully reversible as demonstrated by "washout" experiments. Without inhibiting tumor cell proliferation directly, PTK/ZK results in a significant retardation of tumor growth in a number of experimental tumor models of different tissue origin. Combination of PTK/ZK with an antiandrogen revealed additive effects on tumor-growth inhibition. Treatment efficacy was monitored both by tumor weight and by the determination of serum concentrations of the surrogate marker PSA. PTK/ZK is currently being investigated in patients with different solid tumor types for its therapeutic utility. Preliminary data from phase I/II clinical trials of PTK/ZK as a monotherapy suggested a positive safety and tolerability profile, which we interpret to be a consequence of the high selectivity of the drug for a limited number of kinases. Preliminary response, time to progression, and overall survival data were promising.1 Based on these encouraging results, PTK/ZK is currently in Phase III clinical trials for metastatic colorectal cancer. 相似文献
77.
Roth G Freund S Möhrle B Wöllner K Brünjes J Gauglitz G Wiesmüller KH Jung G 《Chembiochem : a European journal of chemical biology》2007,8(3):323-331
Screening for small peptidic affinity tags for the detection of ubiquitin and ubiquitinated proteins yielded the dodecapeptide amide DPDELRFNAIAL-NH(2) as a specific ubiquitin-interacting ligand. A peptide collection--based on crystal structures with ubiquitin-interacting proteins--was designed and confirmed by sequence comparison of ubiquitin-interacting motifs. Four independent physical detection methods demonstrated that the peptide binds to monomeric ubiquitin with an affinity of about 10 muM and with fast on and off rates. Fluorescence correlation spectroscopy with fluorescent peptides showed specific interaction with ubiquitin. Reflectometric interference spectroscopy with surface-immobilized peptides and isothermal calorimetry measurements confirmed the specific binding of ubiquitin and fast rate constants. (1)H,(15)N heteronuclear NMR localised the interaction site across the beta sheet of ubiquitin. The peptide aligns well with the ubiquitin-interacting motif and represents a lead structure for the rational design of high-affinity tags for targeting ubiquitinated protein in vitro and in vivo. 相似文献
78.
79.
The heat transfer through layers of casting flux has been studied with a laboratory set-up which consists of a water-cooled heat flux probe made of copper and an electrically heated steel plate with a trough to hold the flux sample. The measured heat flux density values were converted to system conductivities ksys which contain the radiation/conduction conductivity in the flux layer and the contact resistance at the probe side. It was found that ksys is almost independent from the layer thickness. Ten commercial casting fluxes were investigated and the data for ksys are given as functions of composition and strand surface temperature. 相似文献
80.
The heat flux densities through thin layers of casting slag have been measured with a soft cooling heat flux probe which made smooth probe/slag interfaces. Thus the contact resistance was avoided. The evaluated effective thermal conductivities were applied, together with the data on the contact resistance, to compute the “system conductivities” existing in the continuous casting “system” water cooled copper/slag/strand. The refractive index and absorption spectrum were measured and used to deduce functions for the radiative and conductive (phonon) conductivities. Although precise values could not be obtained, due to the many assumptions involved, the data indicate that the conductive conductivity does not change drastically at high temperatures and on melting. 相似文献