Evaluation of fall arrest harness sizing schemes

OBJECTIVE: This paper evaluated harness sizing schemes and anthropometric criteria for harness design applications. BACKGROUND: Updated harness sizing systems are needed to accommodate diverse populations in the current workforce. METHOD: Three-dimensional torso scan data and human-harness interfaces from 108 women and 108 men were digitally captured. Abounding box approach was employed to quantify the effect of torso shape and size on fall harness fit. RESULTS: A logistic regression model with eight equations was developed and tested to classify more than 96% of participants to the best-fitting size. CONCLUSION: Study outcomes suggested an alternative system of two sizes for women and three sizes for men over the current four-size unisex system. In addition, thigh strap angle and back D ring location could be utilized along with current harness static fit test criteria to further enhance postfall harness fit predictions. APPLICATION: This research could help reduce the risk of worker injury resulting from poor fit, improper size selection, or failure to don the harness properly.     

QQ旋风边下边播

毫无疑问,网络视频是如今互联网的热点,网民热衷于网络视频已不是一两天了.通常下载到自己想要的视频都要费些功夫,但如果你的网速比较高,就完全能够用QQ旋风边下边播功能,做到下载和播放两不误.掌握QQ旋风视频播放和下载这些实用的技巧,将提升你的娱乐生活品质.     

PDF文档处理Foxit Phantom新体验

作为电子文档长期保存格式的PDF/Archive（PDF/A）经中国国家标准化管理委员会批准已成为正式的中国国家标准,并于2009年9月1日起正式实施的公告发布之后,PDF文档格式的使用将会越来越普遍．它已经从单一功能的小范围的个人使用者上升为需要对PDF文档进行综合处理的政府、企业、个人等类型的用户。其实市面上已有一款功能强大的PDF电子文档套件的产品能实现对PDF文档的综合处理,     

不再有遗感解决"99%下载门"问题

"99%下载门"说的就是在IE浏览器或其他下载软件下载网络资源时,进行到99%时就停了,不能结束下载的问题.关于这类问题相信不少朋友都遇到过,那么出现这种情况主要是由什么原因引起的?有什么切实可行的解决办法呢?下面就一起来讨论讨论.     

右键菜单也玩花样

现在是高效率的时代,忙碌上班、忙碌生活.使用电脑同样是这样,我们都希望能通过最便捷的方法,来实现电脑应用需求.在操作系统中,除了桌面快捷方式外,就数右键菜单可以放置一些常用操作,来提升我们的应用效率了.右键菜单怎么玩?下面就精心为大家准备了几个火热技巧,千万别错过.     

Protein engineering of Aspergillus awamori glucoamylase to increase its pH optimum

To increase the pH optimum of glucoamylase (GA), five mutations-S411G, S411A, S411C, S411H and S411D--were designed to destabilize the carboxylate ion form of Glu400, the catalytic base, by removing or weakening the hydrogen bond between Ser411 and Glu400, and thereby raising its pK. The substitution of alanine, histidine and aspartate were also designed to study the additional effects of polarity and both positive and negative charges, respectively. S411G GA had catalytic efficiencies like those of wild-type GA for isomaltose, maltose and maltoheptaose hydrolysis at pH 4.4, while S411A and S411C GAs had 54- 74% and S411H and S411D GAs had only about 6-12% of wild-type catalytic efficiencies. All five mutations increased the pH optimum in the enzyme- substrate complex, mainly by raising pK1 values. S411A is the best performing and most industrially promising of the pH mutants isolated to date. S411A GA increased the pH optimum by 0.8 units for both maltose and maltoheptaose hydrolysis while maintaining a high level of activity and catalytic efficiency. In hydrolysis of 28% DE 10 maltodextrin, S411A GA had a pH optimum of 7 compared with pH 5.6 for wild-type GA, and had higher initial rates of glucose production than wild-type GA at all pH values tested above pH 6.6.      

Pharmacological effects of propylthiouracil on corticosterone secretion in male rats

BACKGROUND: We investigated the direct effects of propylthiouracil (PTU) on corticosterone secretion both in vivo and in vitro. METHODS: Male rats were divided into 4 groups and then injected subcutaneously with saline, PTU, PTU plus thyroxine (T4), or T4 once daily for 2 weeks. After 2 weeks, rats were decapitated or received adrenocorticotropic hormone (ACTH), intravenously. Zona fasciculata-reticularis (ZFR) cells from normal, saline-, PTU-, PTU plus T4-, or T4-treated rats were incubated with ACTH, forskolin, 8-Br-cAMP, deoxycorticosterone (DOC) +/- PTU (1, 2, or 5 mg/mL) at 37 degrees C for 2 hours. Corticosterone concentrations in plasma and cell media, and 3':5'-cyclic adenosine monophosphate (cAMP) production in ZFR cells were determined by radioimmunoassay. The effects of PTU on the activities of steroidogenic enzymes in ZFR cells were measured by the amounts of intermediate steroidal products separated by thin-layer chromatography. RESULTS: The basal and ACTH-stimulated levels of plasma corticosterone in PTU-treated rats were lower as compared to saline-treated animals. Both basal and ACTH-stimulated corticosterone secretion were inhibited by PTU > 2 mg/mL in rat ZFR cells. The cAMP production induced by forskolin was lower in PTU, PTU plus T4, or T4-treated rats than in saline-treated animals. Chronic administration of PTU or PTU plus T4 inhibited the 3 beta-hydroxysteroid dehydrogenase, 21 beta-hydroxylase, and 11 beta-hydroxylase activities. Administration of PTU (1, 2, and 5 mg/mL) suppressed the basal, ACTH, 8-Br-cAMP, forskolin, and DOC-stimulated corticosterone secretion in rat ZFR cells. Likewise, PTU > 2 mg/mL inhibited the ACTH and 8-Br-cAMP-stimulated levels of intracellular cAMP in rat ZFR cells. CONCLUSIONS: These results suggest that PTU counteracts both basal and ACTH-induced adrenal steroidogenesis through their attenuation of the activity of 11 beta-hydroxylase and cAMP production in rat ZFR cells.