Shot-noise limited,supercontinuum-based optical coherence tomography

We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography (SD-OCT) with an axial resolution of ...     

Enhanced automatic detection of human settlements using Sentinel-1 interferometric coherence

This article presents an experiment in which multi-temporal interferometric coherence calculated from 6-days Sentinel-1A and Sentinel-1B image pairs and backscatter intensity σ° are jointly used for the extraction of built-up areas in the framework of the symbolic machine learning classification. The results obtained with the proposed approach confirm the enhanced capabilities of discriminating built-up areas when using coherence information in comparison to two available global human settlement layers derived: (1) from Landsat optical data and (2) from Sentinel-1 ground range detected data and based on backscatter intensity σ° only. The experiment carried out in The Netherlands Randstad area is expected to be indicative of the results obtainable for urban areas having similar structures and types of built-up.     

The physical and physiological workload of refuse collectors

In order to secure a safer and healthy work situation, the heavy physical loads imposed on 23 refuse collectors (aged 26-54) working in the city of Haarlem, in The Netherlands, were studied in a series of three experiments between 1984 and 1987. The aims were respectively (1) to study the load for workers collecting dustbins or polythene bags; (2) to introduce changes to reduce the load to avoid exceeding the overload criteria by individual refuse collectors; and (3) to investigate the effects of interventions to improve the efficiency of refuse collecting. The maximal isometric lifting force (Fmax) and the maximal aerobic power (VO2max) of 23 refuse collectors were measured in the laboratory. Fmax was measured with an isometric dynamometer pulling with one arm from the floor; the mean value was 912 (+/- 127)N. VO2max was measured running on a treadmill; the mean value was 43.3 (+/- 0.8)ml O2 per kg body mass per min. The physical load on the oxygen transport system was measured through work analysis and by a continuous registration of the heart rate over three working days. Criteria for overload were set at a mean external load of 20% Fmax and a mean energy expenditure of 30% VO2max and an energy expenditure of 50% VO2max or more for a maximum of 60 min per day. Replacement of dustbins by polythene bags resulted in a 70% increase in the total amount of refuse collected, an increase in throwing frequency, but a lower mean load per throw, and no significant differences in the mean heart rate over the working day. When polythene bags were used the mean values did not exceed the overload criteria, but 39% of the individual collectors did have a workload that was too high with respect to one of the criteria. In the last experiment the collectors were advised to reduce their work load by (a) lifting no more than two bags at a time; (b) reducing their walking pace; and (c) taking more breaks. Although compliance with the recommendations was good, and the weight lifted and the walking speed decreased, the physiological load remained the same. This may have been caused by a 15% increase in the total amount of refuse that had to be collected at that time.     

Resource pool management: Reactive versus proactive or let’s be friends

The consolidation of multiple workloads and servers enables the efficient use of server and power resources in shared resource pools. We employ a trace-based workload placement controller that uses historical information to periodically and proactively reassign workloads to servers subject to their quality of service objectives. A reactive migration controller is introduced that detects server overload and underload conditions. It initiates the migration of workloads when the demand for resources exceeds supply. Furthermore, it dynamically adds and removes servers to maintain a balance of supply and demand for capacity while minimizing power usage. A host load simulation environment is used to evaluate several different management policies for the controllers in a time effective manner. A case study involving three months of data for 138 SAP applications compares three integrated controller approaches with the use of each controller separately. The study considers trade-offs between: (i) required capacity and power usage, (ii) resource access quality of service for CPU and memory resources, and (iii) the number of migrations. Our study sheds light on the question of whether a reactive controller or proactive workload placement controller alone is adequate for resource pool management. The results show that the most tightly integrated controller approach offers the best results in terms of capacity and quality but requires more migrations per hour than the other strategies.     

Observed and perceived parental overprotection in relation to psychosocial adjustment in preadolescents with a physical disability: The mediational role of behavioral autonomy.

The purpose of this study was to test a mediational model of associations between parental overprotectiveness (OP), behavioral autonomy, and psychosocial adjustment in 68 families with 8- and 9-year-old preadolescents with spina bifida and a demographically matched sample of 68 families with able-bodied children. Measures included questionnaire and observational assessments of parental OP; parent and child reports of behavioral autonomy; and parent, child, and teacher reports of preadolescent adjustment. On the basis of both questionnaire and observational measures of OP, mothers and fathers of children with spina bifida were significantly more overprotective than their counterparts in the able-bodied sample, although this group difference was partially mediated by children's cognitive ability. Both questionnaire and observational measures of parental OP were associated with lower levels of preadolescent decision-making autonomy as well as with parents being less willing to grant autonomy to their offspring in the future. For the questionnaire measure of OP, and only for the spina bifida sample, the mediational model was supported such that parental OP was associated with less behavioral autonomy, which was, in turn, associated with more externalizing problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans

In response to carbohydrate deprivation or prolonged fasting the ketone bodies, β‐hydroxybutyrate (βHB) and acetoacetate (AcAc), are produced from the incomplete β‐oxidation of fatty acids in the liver. Neither βHB nor AcAc are well utilized for synthesis of sterols or fatty acids in human or rat liver. To study the effects of ketones on cholesterol homeostasis a novel βHB ester (KE) ((R)‐3‐hydroxybutyl (R)‐3‐hydroxybutyrate) was synthesized and given orally to rats and humans as a partial dietary carbohydrate replacement. Rats maintained on a diet containing 30‐energy % as KE with a concomitant reduction in carbohydrate had lower plasma cholesterol and mevalonate (?40 and ?27 %, respectively) and in the liver had lower levels of the mevalonate precursors acetoacetyl‐CoA and HMG‐CoA (?33 and ?54 %) compared to controls. Whole liver and membrane LDL‐R as well as SREBP‐2 protein levels were higher (+24, +67, and +91 %, respectively). When formulated into a beverage for human consumption subjects consuming a KE drink (30‐energy %) had elevated plasma βHB which correlated with decreased mevalonate, a liver cholesterol synthesis biomarker. Partial replacement of dietary carbohydrate with KE induced ketosis and altered cholesterol homeostasis in rats. In healthy individuals an elevated plasma βHB correlated with lower plasma mevalonate.     

Ärztliche Schweigepflicht bei Kindeswohlgefährdung

Definition of the problem Medical confidentiality, which is one of the main pillars of medical ethics, has taken a decisive role in the latest discussions about the improvement of child protection laws. Inexplicit and plurivalent arrangements and procedures of how to legally handle child abuse cases when persons with legal custody refuse to take further support are seen as an obstacle for effective child protection. Arguments Non-specific legal regulations lead to task uncertainty and hesitation on the side of health care professionals, which can result in the delay or even prevention of necessary actions. Therefore, new laws on the federal level have been passed in order to establish certainty with regard to professional secrecy and in order to foster networking among the actors in the field of child protection. Conclusion The paper analyses and discusses these legal attempts at strengthening child protection. Although some of the federal laws have the potential of clarification, the great number of laws and their explication restricts their impact.