A portable device for intensive care brain function monitoring with event-related potentials

Monitoring level of consciousness or depth of sedation is essential in modern intensive care units and emergency rooms. Current methods are based on spontaneous EEG providing only indirect information on the reactivity of the brain. Measurement of auditory event-related potentials (ERPs) has been shown to have additional potential for evaluation of the level of consciousness. Unfortunately, compact and easy-to-use devices are not commercially available. In this study a portable battery-powered device for clinical auditory ERP measurements was designed, constructed and validated. The device consists of a five-channel data logger and a 16-bit stereo audio stimulator. The signals are digitized with a 22-bit sigma-delta analogue-to-digital converter and stored to a PC Card hard disk. Prior to the in vivo application, the device was validated with extensive technical tests. Importantly, the RMS noise amplitude of the EEG channels was found to be less than 1 mivroV and the delivered auditory stimulus intensity corresponded accurately the settings (mean difference 0.2+/-0.5 dB). In addition to technical tests the device was successfully validated in vivo. To summarize, a novel portable instrument for measurement of auditory event-related potentials in intensive care environment is introduced.     

Optimal approximation of signal priors

In signal restoration by Bayesian inference, one typically uses a parametric model of the prior distribution of the signal. Here, we consider how the parameters of a prior model should be estimated from observations of uncorrupted signals. A lot of recent work has implicitly assumed that maximum likelihood estimation is the optimal estimation method. Our results imply that this is not the case. We first obtain an objective function that approximates the error occurred in signal restoration due to an imperfect prior model. Next, we show that in an important special case (small gaussian noise), the error is the same as the score-matching objective function, which was previously proposed as an alternative for likelihood based on purely computational considerations. Our analysis thus shows that score matching combines computational simplicity with statistical optimality in signal restoration, providing a viable alternative to maximum likelihood methods. We also show how the method leads to a new intuitive and geometric interpretation of structure inherent in probability distributions.     

Hard and soft magnetic materials for electromagnetic microactuators

An important aspect of the development of electromagnetic microactuators is the search for suitable materials as well as the development of the respective deposition and patterning processes. Within the Collaborative Research Center 516 “Design and Fabrication of Active Microsystems”, it is the task of the subproject B1 “fabrication of magnetic thin films for electromagnetic microactuators” to perform these investigations. The materials of interest can be divided into two groups: hard magnetic materials and soft magnetic materials. Materials with optimized properties and fabrication processes have been developed within both groups. An example is Samarium–Cobalt (SmCo), which can either be deposited using magnetron sputtering as Sm₂Co₁₇ with a very high energy product or in the SmCo₅ phase using gas flow sputtering with very high deposition rates. In the area of soft magnetic materials, investigations on Nickel-Iron (NiFe) especially NiFe81/19 were followed by the evaluation of NiFe45/55, which features a higher saturation flux density B _s and relative permeability μ _r. Furthermore, current investigations focus on Cobalt-Iron (CoFe) and its further increased saturation flux density B _s and relative permeability μ _r. Current tasks include the stabilization of the fabrication processes to achieve good material properties (i.e. electroplating of CoFe) or a shortening (e.g. by using heated substrates during deposition) by using process alternative not used so far. Another topic is the integration into fabrication processes, i.e. the investigation of process stability and compatibility.     

Relationships between process, microstructure and properties of molded zirconia micro specimens

Due to size effects the mechanical behavior of micro-components with dimensions in the range of some 100 μm and structure details of about 10 μm differs markedly from those of larger components. This is a crucial aspect for the design of micro-components for applications where demands for high strength are critical. The present study, which was performed in the frame of the Collaborative Research Centre 499 (SFB 499), approaches this issue by investigating the relationship between production process, microstructure and the mechanical properties of micro-specimens made from zirconia using two different feedstocks. The specimens were produced by a sintering process. The sintering temperature was varied between 1,300 and 1,500°C. Mechanical and tribological behavior of the specimens was determined by three-point bending tests as well as static and sliding friction tests, respectively. Properties derived from these tests were then correlated to the surface states in the specimens such as porosity, edge radius and roughness. The strength of the micro-specimens was found to be significantly influenced by these surface features. Whilst low porosity alone is not sufficient for high strength, notch effects resulting from pores as well as surface roughness can lower the strength. With increasing edge radius the strength of the material also increases. The porosity, edge radius and surface roughness were mathematically correlated with the strength to allow for a forecast. Within the SFB 499 feedstocks with specific properties were designed and reliable processes were developed to guarantee desirable surface roughness and porosity in the specimens. A characteristic bending strength of about 2,000 MPa is realizable in the micro-specimens within a good statistical reliability. The tribological tests revealed that the wear properties of the zirconia micro-components are strongly dependent on the quality of the feedstock.     

Directed model checking with distance-preserving abstractions

In directed model checking, the traversal of the state space is guided by an estimate of the distance from the current state to the nearest error state. This paper presents a distance-preserving abstraction for concurrent systems that allows one to compute an interesting estimate of the error distance without hitting the state explosion problem. Our experiments show a dramatic reduction both in the number of states explored by the model checker and in the total runtime.     

Phase-retardation and full-polarization analysis of soft-x-ray synchrotron radiation close to the carbon K edge by use of a multilayer transmission filter

We have produced a multilayer transmission filter with 100 periods of Cr/C to achieve a significant phase retardation while maintaining good transmission for photon energies just below the carbon K edge. This device was installed into a polarimeter behind the SX700/3 monochromator at the Berlin synchrotron radiation laboratory, BESSY. The phase-retardation properties were observed as theoretically predicted. Agreement between experiment and calculation could be obtained by introduction of a rather small interface roughness in the simulation code (σ = 0.65 nm rms). An observed phase retardation of 5° was sufficient to permit, for the first time we believe, a complete and unambiguous polarization analysis of soft-x-ray synchrotron radiation (265-eV photon energy) with primary standards.     

Index-distributed planar microlenses for three-dimensional micro-optics fabricated by silver-sodium ion exchange in BGG35 substrates

Fabrication of planar microlens arrays by silver-sodium ion exchange is possible by using a new glass type, optimized for this technology. Because of its nonlinear diffusion response it is well suited to the fabrication of microlens arrays. We show that the diffusion coefficient can be described theoretically by an exponential concentration dependence. The parameters of the planar microlenses are measured interferometrically and by imaging experiments. Because of the specific index distribution, new evaluation techniques for the determination of lens parameters from interferometric measurements have been applied. We also present a simple model that relates the achievable lens parameters to the diffusion conditions.     

Simulation and analysis of pollen coronas

By numerical simulation of light scattering by birch and pine pollen grains, we create color plates of coronas with vertical elliptical shapes and strong brightenings, respectively. The shape of the pollen is modeled by the union of n ellipsoids. The Fraunhofer integral is solved by the use of the fast Hartley transform. The sensitivity of the patterns to pollen orientation, Sun elevation, and pollen shape and size is discussed. Good agreement is obtained with amazing photographs made by a Finnish network of amateur astonomers, in the case of strong vertical orientation of the pollen axis.