A new method for the electro-optical measuring of fast high voltage pulses

This report describes a new method for measuring fast high voltage electric pulses based on one particular application of the Kerr effect. This work was carried out in order to further the development of optical particle detectors. At the present time with our method, the minimum risetime of the measured pulse reaches the nanosecond domain while the maximum voltage is limited only by the physical dimension of the electro-optical transducer.The measuring principle chosen requires a new calibration method in order to reconstruct the observed signal.The use of nitrobenzol as the active liquid allows the continuous modification of the cell sensitivity over a ratio of 1 to 3 without changing the geometry of the cell.     

Novel NMDA antagonists: replacement of the pyridinium ring of 6,11-ethanobenzo[b]quinolizinium cations with heteroisoquinolinium cations

Replacement of the pyridinium ring of 6,11-ethanobenzo[b]quinolizinium cations with thiazolium (4a and 4b) and N-methylimidazolium (4c and 4d) resulted in equipotent compounds in the [3H]TCP binding assay. The corresponding N-methyl-1,2,4-triazolium analogs were less potent in this assay. The thiazolium derivative 4b, with a Ki = 2.9 nM, is being evaluated as a possible neuroprotective N-methyl-D-aspartic acid (NMDA) antagonist.     

Antihyperglycemic activity of phenolics from Pterocarpus marsupium

Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after i.p. administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the effect was comparable to that of 1,1-dimethylbiguanide (metformin).