Helical CT of the breast: detection of intraductal spread and multicentricity of breast cancer

PURPOSE: This study was performed to evaluate the clinical utility of postcontrast helical CT (HCT) scan for the detection of intraductal spread (DS) and multicentricity of breast cancer. MATERIALS AND METHODS: DS and multicentricity in 84 patients with invasive ductal carcinoma were evaluated by preoperative postcontrast HCT. The HCT protocol of 3-mm section width and 3 mm/sec table speed was used with the patients in a supine position. Scanning started 70sec after beginning the intravenous injection of 90 ml (27 gI) of contrast material at the rate of 1.5 ml/sec. The three-dimensional images were displayed. RESULTS: Eighty-four of 84 main tumors (100%) were shown as enhanced masses by postcontrast HCT. The sensitivity and specificity of HCT for the detection of DS and multicentricity were 60.0% (18/30) and 88.9% (48/54), and 88.9% (16/18) and 90.9% (60/66), respectively. When DS and multicentric lesions were combined, the sensitivity and the specificity were 76.3% (29/38) and 89.1% (41/46), respectively. CONCLUSION: HCT of the breast is effective in detecting DS and multicentric lesions of breast cancer and might be useful in helping surgeons to successfully perform breast-conserving surgery.     

Implementation of the periodic boundary condition in thefinite-difference time-domain algorithm for FSS structures

A method for implementing the general Floquet boundary condition in the finite-difference time-domain algorithm (FDTD) is presented. The Floquet type of phase shift boundary condition is incorporated into the time-domain analysis by illuminating the structure with a combination of sine and cosine excitations to generate a phasor representation of the solution at each time step. With this approach, the characteristics of periodic structures comprised of arbitrarily shaped inhomogeneous geometries can be computed for an arbitrary angle of incidence. Theoretical results are compared for various planar frequency selective surfaces (FSS) and for one with a three-dimensional element, e.g., a thick, double, concentric square loop     

The regulation of membrane 125I- and 86Rb+ permeability in a virally transformed cell line (NCL-SG3) derived from the human sweat gland epithelium

We have explored the factors that may regulate membrane permeability in a cell line (NCL-SG3) derived from the human sweat gland epithelium. Ionomycin increased the rate of 125I-efflux from preloaded cells and this action appeared to be due to an increase in intracellular free calcium ([Ca2+]i). The ionomycin-evoked increase in 125I- efflux was reduced in cells that were exposed either to barium or to valinomycin in the presence of a high concentration of external potassium. It thus appears that a fraction of the ionomycin-evoked increase in 125I- efflux is due to the activation of potassium channels and experiments using 86Rb+ also suggested that ionomycin increased the rate of potassium efflux, an effect which was totally abolished by barium. Blockade of Na(+)-K(+)-2Cl- cotransport and of Cl- -HCO3- exchange reduced the basal rate of 125I- efflux and the ionomycin-evoked increase in 125I-efflux from control cells and from cells depolarized by valinomycin. These transport systems thus contribute to anion efflux, although [Ca2+]i-dependent chloride channels also appear to be present. Acetylcholine increases [Ca2+]i in the secretory cells of human sweat glands, but this neurotransmitter did not increase [Ca2+]i in NCL-SG3 cells and so membrane permeability was not under cholinergic control. Adrenaline did not increase [Ca2+]i, but this hormone did evoke cyclic-3',5'-adenosine monophosphate (cyclic AMP) production. However, membrane permeability was not under adrenergic control, as the cells did not appear to express functional, cyclic AMP-dependent anion channels. This may be because they were not fully differentiated under the culture conditions. ATP consistently evoked a dose-dependent increase in anion efflux that appeared to be mediated by [Ca2+]i. The increase in [Ca2+]i was initiated by the release of calcium from a limited internal store and was subsequently sustained by calcium influx. UTP and ADP also increased [Ca2+]i, whereas adenosine, AMP and alpha,beta-methylene ATP were without effect. These data thus suggest that a subclass of type 2 purine receptor, which is functionally coupled to phosphoinositidase C, is present in these cells.     

Effect of functional groups on the triboelectric charging property of polymer particles

Triboelectrification of small polymer particles (< 10 microns) in which various functional groups are introduced by addition of substituted comonomers is studied. The particles are produced by suspension polymerization and mechanical crushing of larger particles. The effect of the different production methods on the particle is described. The particles produced by the polymerization method have a spherical shape with a smooth surface, and those produced by the crushing method have an irregular shape. Studies show that particles that have easily ionizable functional groups are charged more effectively. It is believed the iontransfer route is the dominant mechanism in the triboelectrification charging of the particle. The magnitude of charge becomes saturated after 0.5% addition of substituted comonomers in the particles. The particles produced by the polymerization method have a tendency to be charged effectively compared with those produced by the crushing method. © 1994 John Wiley & Sons, Inc.     

The evaluation of SCC defects of steel pipe using a high-energy X-ray CT sc anner

The X-ray computed CT scanner, capable of producing sharp tomograms, was expected to become a practical and revolutional means in nondestructive inspection in the industrial field.In Japan, the development of the Linac X-ray CT scanner is under way for the inspection of SCC in welds of a nuclear power plant. For development of the Linac-CT, the preliminary experiments for the inspection of SCC artificial defects were performed using a 420 kVp industrial X-ray CT scanner (TOSCANER 4200) which had been developed by Toshiba Corporation. This paper includes the background of this program and the summary of preliminary experiments for X-ray CT.     

Solid-solution composition and powder high-speed steel properties

Translated from Poroshkovaya Metallurgiya, No. 4(316), pp. 52–54, April, 1989.     

A 1.8-V operation RF CMOS transceiver for 2.4-GHz-band GFSK applications

This paper describes a single-chip RF transceiver LSI for 2.4-GHz-band Gaussian frequency shift-keying applications, such as Bluetooth. This chip uses a 0.18-/spl mu/m bulk CMOS process for lower current consumption. The LSI consists of almost all the required RF and IF building blocks: a transmit/receive antenna switch, a power amplifier, a low noise amplifier, an image rejection mixer, channel-selection filters, a limiter, a received signal strength indicator, a frequency discriminator, a voltage controlled oscillator, and a phase-locked loop synthesizer. The bandpass filter for channel selection was difficult to achieve since it operates at a low supply voltage. However, because large interference is roughly rejected at the output of the image rejection mixer and a wide-input-range bandpass filter with an optimized input bias is realized, the transceiver can operate at a supply voltage of 1.8 V. In the IF section, we adopted a circuit design using the minimum number of passive elements, resistors and capacitors, for a lower chip area of 10.2 mm/sup 2/.     

A role of a tip geometry on STM images

Scanning tunnelling microscopes operable in both ultrahigh vacuum (UHV) and aqueous conditions are described with emphasis on a tip geometry. An atomically resolved STM image was obtained for the Si(111)-Mo√3 surface in UHV condition and changes of a diffraction grating surface in aqueous condition due to an electrochemical reaction were monitored.     

Prevalence and characteristics of exercise-induced asthma in children

We have evaluated the prevalence and the characteristics of exercise-induced asthma (EIA) in a group of 71 patients with a prior history of mild, moderate or severe asthma (42 males and 29 females), aged 6-16 years-old. Measurements of the forced expiratory volume in 1 second (FEV1) were obtained before and at regular intervals up to 8 hours following exercise. As a control, the same patients were evaluated at similar time intervals on another day when they had not been submitted to an exercise challenge. Using pre-exercise FEV1 values as the reference, 32 patients (45.1%) had a positive exercise challenge, defined as a fall in FEV1 value equal to or greater than 15% from baseline following exercise. Among the patients with a positive exercise challenge, the majority (23/32, 71.8%) had an immediate response alone, with no significant changes in FEV1 within the 8-hour follow-up. However, a subgroup of patients (9/32, 28.1%) had both an immediate and a late-phase response to exercise. During the control day, no significant fall in FEV1 were observed. In keeping with previous investigations, no correlation was found between a history of EIA and a positive exercise challenge in the present study. Positive exercise challenges were found more frequently among patients with moderate and severe asthma than patients with mild asthma.     

Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD

Acute graft-versus-host disease (aGVHD) remains a major barrier to a wider application of allogeneic bone marrow transplantation (BMT). Although this complication is mainly dependent on donor-derived T lymphocytes, very little information is available concerning the mechanism of lethality. In this study, we investigated both the expression of Fas/Fas-ligand (FasL) and lymphocyte subset reconstitution in patients who underwent HLA-matched related allogeneic BMT (n = 16) and normal donors (n = 10), and several distinct features were observed. First, the reconstitutions of CD3+ and CD56+ cells were different between the aGVHD+ and aGVHD- group. In particular, the percentage of CD3-CD56+ cells was significantly decreased in patients with aGVHD (P < 0.01). Second, the expansion of CD8+ (P = 0.01) and CD8+ CD28- T cells (P = 0.03) was a characteristic finding in patients with aGVHD. Finally, we found that the percentages of Fas+CD8+, Fas+HLA-DR+ and FasL+ CD8+ cells were significantly increased. Fas antigen was highly coexpressed on most of the lymphocyte subsets, especially on CD8+ cells (P < 0.01), and also, significantly higher coexpression of FasL on CD8+ cells was found in patients with aGVHD (P < 0.01). In summary, an increase in the percentage of CD8+ cells which express Fas and its ligand in patients with aGVHD after BMT points to a possible role for the Fas/FasL pathway in the effector phase of aGVHD.