The first damage-free top-down fabrication processes for a two-dimensional array of 7 nm GaAs nanodiscs was developed by using ferritin (a protein which includes a 7 nm diameter iron core) bio-templates and neutral beam etching. The photoluminescence of GaAs etched with a neutral beam clearly revealed that the processes could accomplish defect-free etching for GaAs. In the bio-template process, to remove the ferritin protein shell without thermal damage to the GaAs, we firstly developed an oxygen-radical treatment method with a low temperature of 280?°C. Then, the neutral beam etched the defect-free nanodisc structure of the GaAs using the iron core as an etching mask. As a result, a two-dimensional array of GaAs quantum dots with a diameter of ~ 7 nm, a height of ~ 10 nm, a high taper angle of 88° and a quantum dot density of more than 7 × 10(11) cm(-2) was successfully fabricated without causing any damage to the GaAs. 相似文献
It is demonstrated that patterned inorganic phosphor films consisting of rare earth ion doped nanoparticles (RE‐NPs) can be fabricated on plastic sheets using calcination‐ and etching‐free photolithography. Green up‐conversion luminescence and near‐infrared (NIR) fluorescence appears from the RE‐NPs that are prepared from Y2O3 doped with 1 mol% Er3+ and 0.85 mol% Yb3+. The diameter of the RE‐NPs is estimated to be about 300 nm using dynamic light scattering. Visible transmittance of the RE‐NP film fabricated by dip‐coating is more than 90%. Patterned RE‐NP films are obtained by dip‐coating the RE‐NPs on patterned photoresist films fabricated by UV exposure through a photomask, followed by selective removal of the photoresist. Optical, fluorescence, scanning electron, atomic force, and Kelvin probe force microscopies are used for the characterization of the patterned RE‐NP films. The present methodology enables fabrication of patterned RE‐NP films, not only on inorganic substrates but also on plastic sheets, with low cost and material consumption. 相似文献
The increasing use of nanomaterials has raised concerns about their potential risks to human health. Recent studies have shown that nanoparticles can cross the placenta barrier in pregnant mice and cause neurotoxicity in their offspring, but a more detailed understanding of the effects of nanoparticles on pregnant animals remains elusive. Here, we show that silica and titanium dioxide nanoparticles with diameters of 70 nm and 35 nm, respectively, can cause pregnancy complications when injected intravenously into pregnant mice. The silica and titanium dioxide nanoparticles were found in the placenta, fetal liver and fetal brain. Mice treated with these nanoparticles had smaller uteri and smaller fetuses than untreated controls. Fullerene molecules and larger (300 and 1,000 nm) silica particles did not induce these complications. These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups. 相似文献
Journal of Infrared, Millimeter, and Terahertz Waves - A pixel in an uncooled microbolometer terahertz (THz) focal plane array (FPA) has a suspended structure above read-out integrated circuit... 相似文献
Objective: The hepatic metabolism of six compounds newly synthesized as retinoid X receptor agonists was characterized in rat and human liver microsomes to examine the relationship between their hepatic metabolism profiles and side chain structures, considering the interspecies difference.
Materials and methods: The compounds used have a 6-[N-ethyl-N-(3-alkoxy-4-isopropylphenyl)amino]nicotinic or 6-[N-ethyl-N-(4-alkoxy-3-isopropylphenyl)amino]nicotinic acid skeleton, in which the isopropoxy, isobutoxy or cyclopropylmethoxy group is employed for the alkoxy group. These compounds were incubated with the microsomes, and their Michaelis--Menten parameters were determined. The incubation study was also performed with various cytochrome P450 (CYP) inhibitors to examine their susceptibilities to the inhibitors. In addition, a molecular docking simulation was conducted to assess the compound’s spatial configuration with the CYP isoform when necessary.
Results: The Michaelis--Menten parameters determined are comparable between rats and humans for the compounds having 3-isobutoxy, 4-isobutoxy, 4-isopropoxy and 4-cyclopropylmethoxy groups. However, it was indicated that all compounds except that having the 3-isobutoxy group are metabolized in a different manner between rats and humans. That is, the extent of the contribution of each CYP isozyme is different between those two species. A molecular docking simulation showed that the spatial configuration of the compound to be associated with CYP2D6 markedly changes depending on whether the isobutoxy group is situated at the 3- or 4-position.
Conclusion: A slight difference in the side chain structures markedly alters the compound’s metabolic profile, which amplifies the interspecies difference regarding the profile, increasing the difficulty in characterizing the profile in humans with the structural-property relationship and interspecies extrapolation. 相似文献
The effect of high‐pressure oxygen (HPO) annealing on the electrical, magnetic, and magnetoelectric (ME) properties of room‐temperature multiferroic BaSrCo2Fe11AlO22 ceramics was investigated. The electrical resistivity of the ceramics was found to strongly depend on the partial oxygen pressure during annealing at 1040°C. Samples annealed under ~10 atm of oxygen exhibited a resistivity of up to 1.6 × 109 Ω·cm at room temperature, more than two orders of magnitude higher than that of samples without oxygen annealing. Thermally stimulated current and complex impedance measurements suggested that the enhancement of the resistivity by the HPO annealing originated from a decrease in the amount of defects related to oxygen vacancies and an increase in the resistance of grains and interfaces. HPO annealing also affects the magnetic‐field response of spiral magnetic ordering, which is ascribed to the ME properties. Furthermore, samples subjected to HPO annealing exhibited a lower contribution of the space charges trapped at the grain boundaries and/or defects to the magnitude of the measured magnetoelectrically induced electric polarization P. The present results indicate that HPO annealing is an effective method to evaluate authentic ME effects in multiferroic BaSrCo2Fe11AlO22 ceramics. 相似文献
Fatty acid monoesters of the title compound (DHSred), of variable carbon chain length (propionate, laurate, myristate, palmitate, and stearate), were synthesized, and their antioxidant capacities were evaluated by means of a lipid peroxidation assay with lecithin/cholesterol liposomes. The selenides with long alkyl chains exhibited significant antioxidant activity (IC50=9–34 μM ) against accumulation of lipid hydroperoxide. Incorporation of the myristate into the liposome was ≈50 % by EPMA analysis. Intermediacy of the selenoxide was examined by NMR. In addition, enhancement of interfacial redox catalytic activity was observed for the myristate, but not for PhSeSePh and edaravone, in a PhCl/H2O biphasic peroxidation assay. These results suggested that a combination of a hydrophilic selenide moiety as a redox center with a long alkyl chain is an effective approach to selenium antioxidants with interfacial glutathione‐peroxidase‐like (GPx‐like) activity. The activity can be controlled by the alkyl chain length. 相似文献
The aim of the present study is to propose innovative predictive models for shear capacity of reinforced concrete (RC) exterior joints in terms of multiple soft computing techniques. Existing models were evaluated and by a preliminary sensitivity analysis, seven parameters including compressive strength of concrete, product of the yield stress and the reinforcement ratio of the joint stirrups, the effective width of the joint panel, cross‐sectional column width, beam tensile longitudinal reinforcement ratio, beam compressive longitudinal reinforcement ratio, and column longitudinal reinforcement ratio were considered. Then, a large data set having the details of experimental programs on shear capacity of exterior RC beam–column joints was provided. The experimental data were utilized in developing the proposed models. After verification of the new models against available database, their efficiency compared with existing models was confirmed. Finally, a sensitivity analysis was performed in order to find the relative importance of each input parameter on the shear strength of RC joints. The results indicated that the beam reinforcement is the most important factor in shear capacity estimation of exterior RC beam–column connections. 相似文献
During the course of our studies to develop new uses for the Noni (Morinda citrifolia) root, 10 anthraquinones, rubiadin (1), rubiadin 1-methyl ether (2), lucidin (3), damnacanthol (4), 1,3-dihydroxy-2-methoxymethylanthraquinone (5), 3-hydroxy-1-methoxy-2-methoxymethylanthraquinone (6), nordamnacanthal (7), damnacanthal (8), sorandidiol (9) and morindone (10), were isolated. Compounds 5, 6, 7, 8 and 10 exhibited remarkable inhibition against the activities of animal pols, and compound 10 was the strongest inhibitor in the anthraquinones investigated. Among mammalian pols, compound 10 inhibited the pol activities of A- (pol γ), B- (pols α, δ and ε) and Y- (pols η, ι and κ) families, but did not influence the activities of X-family pols (pols β, λ and terminal deoxynucleotidyl transferase). The tendency of pol inhibition showed a positive correlation with the suppression of human colon cancer cell HCT116 growth. These results suggested that the Noni root containing anthraquinones may be used as an anticancer functional food. 相似文献