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排序方式: 共有345条查询结果,搜索用时 17 毫秒
31.
K Kono F Ichihara H Iizuka T Sekikawa Y Matsumoto 《Canadian Metallurgical Quarterly》1997,71(6):978-981
We established gastric cancer-specific CD8+ T-cell (T(CD8+)) lines derived from different lymphocyte sources in the same patients by repeated stimulation with mitomycin-C-treated autologous tumor cells with low-dose interleukin-2, and we compared recognition patterns among the T(CD8+) derived from solid tumor, lymph node metastasis and ascites in the same patient (n = 3) to determine their similarities and differences for therapeutic purposes. We confirmed that gastric cancer-specific T(CD8+) lines can be isolated, in a MHC class I-restricted manner, from solid tumors, metastatic lymph nodes and malignant ascites. T(CD8+) lines derived from tumor-infiltrating lymphocytes (TIL) in solid tumor recognized autologous tumor cells derived from solid tumor, but not autologous tumor cells derived from ascites or metastatic lymph node, while T(CD8+) lines derived from tumor-associated lymphocytes (TAL) in malignant ascites recognized autologous tumor cells derived from ascites, but not tumor cells from solid tumor or metastatic lymph node. Furthermore, T(CD8+) lines derived from regional lymph node lymphocytes (RLNL) recognized autologous tumor cells derived from metastatic lymph nodes, but not tumor cells derived from ascites. No significant differences were seen in MHC class I expression among the tumors derived from solid tumor, lymph node metastasis or ascites in the same patient. This suggests that there are differences of recognition patterns among the TILs, TALs and RLNLs in the same patient and that it is important to consider the source of lymphocytes, e.g., a combination of TILs, TALs and RLNLs, for adoptive immunotherapy in gastric cancer patients. 相似文献
32.
Tatsuyuki Kawamura Tomohiro Fukuhara Hideaki Takeda Yasuyuki Kono Masatsugu Kidode 《Personal and Ubiquitous Computing》2007,11(4):287-298
In this paper we propose an object-triggered human memory augmentation system named “Ubiquitous Memories” that enables a user
to directly associate his/her experience data with physical objects by using a “touching” operation. A user conceptually encloses
his/her experiences gathered through sense organs into physical objects by simply touching an object. The user can also disclose
and re-experience for himself/herself the experiences accumulated in an object by the same operation. We implemented a prototype
system composed basically of a radio frequency identification (RFID) device. Physical objects are also attached to RFID tags.
We conducted two experiments. The first experiment confirms a succession of the “encoding specificity principle,” which is
well known in the research field of psychology, to the Ubiquitous Memories system. The second experiment aims at a clarification
of the system’s characteristics by comparing the system with other memory externalization strategies. The results show the
Ubiquitous Memories system is effective for supporting memorization and recollection of contextual events. 相似文献
33.
A new formulation of the finite-element method to analyze nonreciprocal waveguides in magneto-photonic crystals (MPCs) is proposed. Accurate solutions of light propagations for two different directions are obtained by the asymmetrical input condition. As numerical examples, the performance of a waveguide-type optical isolator in MPCs designed by the eigenmode analyses is confirmed by using this method. Subsequently, an effective way to enhance the nonreciprocity of the optical isolator is shown. 相似文献
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Sera from 23 patients with idiopathic thrombocytopenic purpura (ITP), 14 patients with aplastic anemia with severe thrombocytopenia and healthy control subjects were tested for the presence of fibrinogen/fibrin degradation products (FDP), using the tanned red cell hemagglutination inhibition immunoaassay. The concentrations of circulating FDP of ITP patients (mean 12.01 mug/ml) were significantly higher than those of the patients with aplastic anemia (mean 4.01 mug/ml, p less than 0.05) or normal controls (mean 3.10 mug/ml, p less than 0.001). The patients with untreated ITP with very low platelet counts had higher levels of FDP than those of the treated group (p less than 0.01). Serum FDP and a battery of other coagulation-fibrinolysis tests were serially carried out over a period of 10 weeks in two patients with ITP. The initially high FDP promptly decreased as circulating platelets increased in response to steroid in both patients, while plasma fibrinogen, euglobulin lysis time, prothrombin time and partial thromboplastin time remained essentially normal during the course of observation. The exact source of the increased serum FDP in ITP was not established, but a few possible mechanisms responsible for this abnormality were discussed. 相似文献
37.
OBJECTIVES: The purpose of this study was to examine the temporal relation between the development of a third heart sound during the course of evolving heart failure and associated hemodynamic abnormalities. BACKGROUND: Although various theories have been proposed to explain the origin of the third heart sound, the exact origin of this sound remains unknown. METHODS: Studies were performed in seven dogs in which heart failure was produced by multiple sequential intracoronary micro-embolizations. Hemodynamic studies including ventriculography, pulsed wave Doppler echocardiography and intracardiac phonocardiography were performed at baseline, at the time at third heart sound was first heard and at 6 and 24 weeks after onset of the third heart sound. RESULTS: All dogs developed a third heart sound at 9 +/- 2 weeks after the initial embolization. The onset of the sound was accompanied by an increase in left ventricular chamber stiffness relative to the baseline value (0.25 +/- 0.03 vs. 0.14 +/- 0.01 mm Hg/ml) (p < 0.05) and mean deceleration of early mitral inflow velocity (1,040 +/- 90 vs. 590 +/- 40 cm/s per s) (p < 0.05). CONCLUSIONS: These data indicate that the onset of a third heart sound during the course of evolving heart failure occurs coincident with the development of increased left ventricular chamber stiffness and the manifestation of rapid deceleration of early mitral inflow velocity. These findings are consistent with a myocardial vibratory origin of this sound. 相似文献
38.
The viscosity lowering of toluene solutions of isobutylene-isoprene rubber, polyisobutylene, and ethylene-propylene rubber in the reaction with dicumyl peroxide was investigated. By using the kinetic equations for the reaction of rubber with peroxide which had been derived previously by KIRIYAMA et al. the results of the experiments are discussed. 相似文献
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40.
Y Nonomura H Yoneda T Sakai Y Inayama Y Kono J Koh J Sakai Y Inada A Takai H Asaba 《Canadian Metallurgical Quarterly》1996,93(2-3):138-141
We investigated point mutations of the APP gene in 66 patients with sporadic Alzheimer's disease (AD) and 180 normal individuals by use of the PCR (polymerase chain reaction) method. Both the AD patients and the normal individuals were Japanese. We extracted DNA from blood samples using the phenol-chloroform method and amplified exons 16 and 17 of the APP gene by PCR. PCR products were digested by MBO-II (exon 16) and BCL-1(exon 17). Electrophoresis was carried out with 3% agarose gel and the separated fragments were stained with ethidium bromide. In addition we investigated other point mutations of exons 16 and 17 by use of the PCR-SSCP (single stranded conformation polymorphisms) method, and found no fragments that exhibited point mutations in the AD patients and normal individuals. These findings indicate that the presence of point mutation of the APP gene is not a major cause of AD in the Japanese population. 相似文献