On gracefully degrading multiprocessors with multistageinterconnection networks

The behavior of a multiprocessing system with a multistage interconnection network is studied in the presence of faulty components. Measures for the connectivity and performance of these systems are proposed, including the average number of operational paths, the average number of accessible processors and memories, the average number of fault-free processors (memories) that are connected to an accessible memory (processor), the bandwidth, and the processing power of the system. Based on these measures, a tight upper bound for the maximal fully connected system is suggested. The gracefully degrading system is then compared, through some numerical examples, to a system whose faulty components are repaired upon failure. Based on these comparisons, the anticipated reduction in system performance can be estimated and consequently, appropriate maintenance policies can be determined     

Robust Superlubricity of Gold–Graphite Heterointerfaces

Noncommensurate 2D interfaces hold great promise toward low friction and nanoelectromechanical applications. For identical constituents, the crystals interlock at specific rotational configurations leading to high barriers for slide. In contrast, nonidentical constituents comprising different lattice parameters should enable robust superlubricity for all rotational configurations. This is however not the case for gold–graphite interfaces, as both theory and experiments show scaling behavior of the sliding force as a function of the interface contact area. By simulating the sliding force for gold–graphite interfaces, this work shows that the origin for high force barriers at special angular configurations is a result of commensurability between the moiré structure and the contact geometry. Consequently, this paper suggests new geometries that can potentially overcome such commensurability effects to enable robust superlubricity.     

The pharmacokinetics and pharmacodynamics of the oral iron chelator deferiprone (L1) in relation to hemoglobin levels

Recently, we demonstrated that administration of the orally active iron chelating agent deferiprone (1,2-dimethyl-3-hydroxypyrid-4-one (L1)) at 6-hour intervals results in significantly greater urinary iron excretion than that induced during administration of the drug at 12-hour intervals. That study was conducted in thalassemia patients, all of whom had received a packed red cell transfusion of 15 cc/kg. 72 hours prior to evaluation of urinary iron excretion, at a time when endogenous erythropoiesis would be expected to be at its lowest. In clinical practice however, thalassemia patients, suppression of endogenous erythropoiesis is not sustained between transfusions. We set out to determine the influence that administration of deferiprone has on urinary iron excretion at lower hemoglobin concentrations, immediately prior to transfusion. We hypothesized that hemoglobin levels will affect the ability of deferiprone to chelate iron. Ten regularly transfused patients with homozygous beta-thalassemia (HBT) aged mean +/- SD, 20.9 +/- 4.7, range 13 - 27 years, receiving long-term therapy with deferiprone, were treated with deferiprone 75 mg/kg/day, administered every 6 hours (or every 12 hours) for 72 hours immediately prior to a blood transfusion in the first month. One month later each patient received the other of the 2 dosing regimens for 72 hours immediately prior to transfusion. The deferiprone-induced 24-hour urinary iron excretion was similar during both dosing regimens; 0.56 +/- 0.45 mg/kg when L1 was given every 6 hours and 0.48 +/- 0.52 mg/kg when L1 was administered every 12 hours (p = 0.79). However, the calculated 24-hour area under the plasma concentration-time curve (AUC0-24) of deferiprone was significantly lower when deferiprone was administered at 6-hour intervals (6,762.8 +/- 1,601.6 mg*min/l), than that observed when deferiprone was administered every 12 hours (8,250.1 +/- 1,235.7 mg*min/l) (p = 0.04). The pharmacokinetics of deferiprone when administered immediately prior to transfusions are different from those following transfusions. More studies assessing total body iron excretion are needed to determine the contribution of the fecal route in iron excretion.     

Histological changes induced by CO2 laser microprobe specially designed for root canal sterilization: in vivo study

Sixty-six class-II CAD/CAM-manufactured ceramic inlays (Cerec) were placed in 27 patients. Each patient received at least one inlay luted with a dual-cured resin composite and one inlay luted with a chemically cured resin composite. The inlays were examined 5 years after luting using the California Dental Association (CDA) criteria. Eighty-nine percent of the 66 inlays were rated 'satisfactory'. During the follow-up period replacement was required for 3 inlays because of inlay fractures (4.5%) and 1 inlay because of fracture of the tooth substance (1.5%). All those inlays were luted with the dual-cured resin composite luting agent. Of the remaining 62 inlays the CDA rating 'excellent' was given to 84% for color, 97% for surface, and 81% for anatomic form. 'Excellent' margin integrity was seen in 52% of the dual-cured resin composite luted inlays and in 61% of the chemically cured resin composite luted inlays. No statistically significant (P> 0.05) difference was observed between the two luting agents.     

4.5 Gbit/s modelocked extended-cavity laser with a monolithically integrated electroabsorption modulator

An electroabsorption modulator has been monolithically integrated with an extended-cavity laser, which incorporates a Bragg reflector. Actively modelocked at the fundamental cavity resonance frequency of 4.5 GHz, the laser provides a train of 6.3 ps pulses with a centre wavelength of 1544 nm onto which data is encoded by the modulator. This 4.5 Gbit/s single-chip transmitter is suitable for systems employing short optical pulses.<>     

Software-Based Failure Detection and Recovery in Programmable Network Interfaces

Emerging network technologies have complex network interfaces that have renewed concerns about network reliability. In this paper, we present an effective low-overhead fault tolerance technique to recover from network interface failures. Failure detection is based on a software watchdog timer that detects network processor hangs and a self-testing scheme that detects interface failures other than processor hangs. The proposed self-testing scheme achieves failure detection by periodically directing the control flow to go through only active software modules in order to detect errors that affect instructions in the local memory of the network interface. Our failure recovery is achieved by restoring the state of the network interface using a small backup copy containing just the right amount of information required for complete recovery. The paper shows how this technique can be made to minimize the performance impact to the host system and be completely transparent to the user.     

Are there sex differences in neuropsychological functions among patients with schizophrenia?

OBJECTIVE: Studies of sex differences in neuropsychological performance in schizophrenia report inconsistent results, due in part to methodological artifacts. The study presented here was specifically designed to examine sex differences in neuropsychological performance. It was hypothesized that schizophrenic women would exhibit fewer neuropsychological deficits than schizophrenic men and that their performance would be more similar to that of normal women than schizophrenic men's performance would be to that of normal men. METHOD: Thirty-one outpatients with DSM-III-R-defined schizophrenia were systematically sampled from an extensive service network serving a large urban catchment area for seriously mentally ill persons. Twenty-seven normal comparison subjects were matched within sex on the basis of age, parental socioeconomic status, ethnicity, and handedness. An extensive neuropsychological test battery was administered, and multivariate analysis of variance was used to test for the effects of sex and group and sex-by-group interactions. RESULTS: Male patients were significantly impaired across all functions in comparison with normal male subjects and on tests of attention, verbal memory, and executive functions in comparison with female patients. Female patients performed significantly worse than female normal comparison subjects only on tests of attention, executive functions, visual memory, and motor functions. CONCLUSIONS: The findings suggest that women with schizophrenia may be less vulnerable to particular cognitive deficits, especially those involving verbal processing, than schizophrenic men.     

Multifunctional Magnetic Optical Sensor Particles with Tunable Sizes for Monitoring Metabolic Parameters and as a Basis for Nanotherapeutics

Magnetic optical sensor particles with multifunctional cores and shells are synthesized via a facile nanoprecipitation method and the subsequent modification of the particle shell. The hydrophobic particle core includes optical oxygen indicators, a light harvesting system, photosensitizers, and magnetic nanoparticles. Further functionalities are introduced by modifying the shell with enzymes, antibodies, multiple layers of polyelectrolytes, stimuli‐responsive polymers, and luminescent indicator dyes. The hydrodynamic diameter is tunable by varying different precipitation parameters.     

Comment on `Nonplanar VLSI arrays with high fault-tolerancecapabilities'

In the above-named work (see ibid., vol.38, p.51-7, April 1989), S. Lafiti and A. El-Amawy apply, in a straightforward manner, the method developed by A.D. Singh (1985) to calculate lower bounds for the yield of nonplanar interstitial redundancy topologies of processor arrays with spare processors. In their introduction, they claim that the models suggested by I. Koren and D.K. Pradhan (1987) are highly theoretical since the number of states in the Markov model might be very large and the determination of the transition rates might be intractable. They add that applying some empirical rules, as suggested by Koren and Pradhan (1987), can lead to unrealistic results and may require a large number of computations. They also claim that the model of Koren and Pradhan does not suggest an algorithm to replace faulty elements. They conclude that a simpler model, like the one proposed by Singh, is needed for calculating the yield of fault-tolerant processor arrays. In the present comment, Koren and Pradhan respond to the above comments and attempt to clarify the differences between their yield analysis and that of Singh     

Scalable reconfigurable equipment design principles

Scalability is one of six key characteristics found in reconfigurable manufacturing systems. Scalable systems satisfy changing capacity requirements efficiently through system reconfiguration, and in the flexible manufacturing literature this capability is called expansion flexibility. The development of modular scalable machine tools is a necessary precursor to achieving scalable systems. Unfortunately, there is little work describing the design of scalable machines. This paper establishes the need for scalable machines and a basis for evaluating and describing them. Applicable metrics are defined, and an architecture for scalable machines is presented. Two examples illustrate the scalable architecture. Finally, a design parameter based on a mathematical approach is presented to determine the optimal number of modules to be included on a modular scalable machine. This as a design parameter is important because it limits machine size and the number of module interfaces included in the base machine structure.