In vivo imaging of brain nicotinic acetylcholine receptors with 5-[123I]iodo-A-85380 using single photon emission computed tomography

The distribution and kinetics of 5-[123I]iodo-A-85380, a novel ligand for brain nicotinic acetylcholine receptors (nAChRs), were evaluated in the Rhesus monkey using single photon emission computed tomography (SPECT). Peak levels of radioactivity were measured in brain at 90 min after injection of the tracer. Accumulation of radioactivity was highest in the thalamus, intermediate in the frontal cortex and basal ganglia, and lowest in the cerebellum. The ratio of specific to nonspecific binding (V3") in the thalamus, estimated from the (thalamic-cerebellar)/cerebellar radioactivity ratio, reached a value of 6 at 4 h post-injection. Specific binding was reduced by subcutaneous injection of 1 mg/kg cytisine at 2.25 h after injection of radiotracer. At 2.5 h after cytisine administration, radioactivity in the thalamus was reduced by 84%, in the frontal cortex, by 76%, and in the basal ganglia, by 57% of the level measured at the time of cytisine administration, demonstrating that the binding was reversible. On the basis of these findings, together with other data indicating high affinity, receptor subtype selectivity, low nonspecific binding and lack of toxicity in animals, 5-[123I]iodo-A-85380 appears to be a promising ligand for SPECT imaging of nAChRs in the human brain.     

Semiconductor optical amplifier array coupled to uncoated flat-endfibers with integrated beam expanders and TiO2 antireflectioncoatings

We present a novel coupling scheme consisting of an integrated beam expander, a specifically tailored TiO₂ antireflection coating, optical index matching gel, and uncoated flat-end single-mode fiber (SMF). This scheme was used to package four-channel semiconductor optical amplifier arrays. Far-field profiles for each discrete amplifier in the array are typically 80 and 150 FWHM, perpendicular and parallel to the junction plane, respectively. The TiO₂ AR coating overcomes the indices mismatching of fiber glass and InP based device, and reduce optical reflection to 0.002% at 1.55 μm. Misalignment tolerance in the l-dB excess loss range, for a discrete channel, is typically 5 μm vertically and 8 μm laterally. The average coupling loss is 4.3 dB per facet for the devices measured. Fiber coupled small signal gain for the amplifiers is typically 11.6 dB and a saturation output power of 3.0 dBm. The method of characterization and optimization of the TiO₂ coating is discussed     

The design of a collaborative interface for narration to support reconciliation in a conflict

This paper is about the development of a face-to-face collaborative technology to support shifting attitudes of participants in conflict via a narration task. The work is based on two cultural elements: conflict resolution theory and the design of a collaboration enforcing interface designed specifically for the task. The general claim is that participants may achieve a greater understanding of and appreciation for the other’s viewpoint under conditions that support partaking in a tangible joint task and creating a shared narration. Specifically, a co-located interface for producing a joint narration as a tool for favoring reconciliation is presented and discussed. The process based on this technology implicitly includes classical steps in conflict resolution approaches, such as escalation and de-escalation. Our goal is to show that this interface is effective and constitutes an alternative to a typical face-to-face moderated discussion.     

Design of reconfigurable manufacturing systems

This paper explains the rationale for the development of reconfigurable manufacturing systems, which possess the advantages both of dedicated lines and of flexible systems. The paper defines the core characteristics and design principles of reconfigurable manufacturing systems (RMS) and describes the structure recommended for practical RMS with RMS core characteristics. After that, a rigorous mathematical method is introduced for designing RMS with this recommended structure. An example is provided to demonstrate how this RMS design method is used. The paper concludes with a discussion of reconfigurable assembly systems.     

Application-Level Fault Tolerance as a Complement to System-Level Fault Tolerance

As multiprocessor systems become more complex, their reliability will need to increase as well. In this paper we propose a novel technique which is applicable to a wide variety of distributed real-time systems, especially those exhibiting data parallelism. System-level fault tolerance involves reliability techniques incorporated within the system hardware and software whereas application-level fault tolerance involves reliability techniques incorporated within the application software. We assert that, for high reliability, a combination of system-level fault tolerance and application-level fault tolerance works best. In many systems, application-level fault tolerance can be used to bridge the gap when system-level fault tolerance alone does not provide the required reliability. We exemplify this with the RTHT target tracking benchmark and the ABF beamforming benchmark.     

Drawing directed graphs using quadratic programming

We describe a new method for visualization of directed graphs. The method combines constraint programming techniques with a high performance force-directed placement (FDP) algorithm. The resulting placements highlight hierarchy in directed graphs while retaining useful properties of FDP; such as emphasis of symmetries and preservation of proximity relations. Our algorithm automatically identifies those parts of the digraph that contain hierarchical information and draws them accordingly. Additionally, those parts that do not contain hierarchy are drawn at the same quality expected from a nonhierarchical, undirected layout algorithm. Our experiments show that this new approach is better able to convey the structure of large digraphs than the most widely used hierarchical graph-drawing method. An interesting application of our algorithm is directional multidimensional scaling (DMDS). DMDS deals with low-dimensional embedding of multivariate data where we want to emphasize the overall flow in the data (e.g., chronological progress) along one of the axes.     

Spontaneous Generation of Magnetic Flux in Superconductors: Testing the Model

The Kibble-Zurek scenario of the generation of topological defects, applied to superconductors, predicts the spontaneous formation of magnetic flux during a rapid quench through T^c. The predicted amount of net flux scales as the 1/8 power of the cooling rate, and as the square root of the circumference of the sample. Our experimental data is broadly consistent with the first prediction, while the second one is yet to be tested. We describe a proposed experiment to test this prediction. In addition, we describe additional observations of spontaneous flux generated through a different mechanism. PACS numbers: 05.70.Ln, 74.40.+k, 11.27.+d.     

Full-duplex optical transmission using self-heterodyne lasertransceivers

The use of semiconductor diode lasers simultaneously as heterodyne receivers and lightwave transmitters in a full-duplex single optical fiber transmission system is reported. A transmission distance of 16 km, limited by Rayleigh backscattering, is obtained at a bit rate of 40 Mb/s for this simple system, which requires no optical couplers or photodiodes. The proposed operation is analogous to that of the so-called autodyne radio receiver in which the local oscillator circuit also performs the heterodyne mixing. The optical counterpart is called a self-heterodyne mixer and offers the same frequency selectivity and tunability as a conventional heterodyne detector but with reduced receiver complexity. In the self-heterodyne receiver, an optical signal to be detected is introduced directly into the lasing cavity by coupling the signal into the laser through an uncoated cleaved end facet. Changes in the optical cavity field, which result from interference between the lasing mode and the injected signal, modulate the rate of stimulated carrier recombination and thus produce a change in the injection current. This alternating current component is detected and amplified in the laser active region bias     

An interactive VLSI CAD tool for yield estimation

The yield of a VLSI chip depends on the sensitivity of the chip to defects occurring during the fabrication process, among other factors. To predict this sensitivity, one usually needs to compute the so-called critical area (A_c), which reflects how many and how large the defects must be in order to result in a circuit failure. The main computational problem in yield estimation is to calculate A_c efficiently for complicated, irregular layouts. A novel approach is suggested for this problem that results in an algorithm that will solve it efficiently. This paper provides an interactive, accurate, and fast method for the evaluation of critical area as a design tool; the tool utilizes good visual feedback to allow layout improvement for higher yield. The algorithm is compared to other yield-prediction methods, which use either the Monte Carlo approach (VLASIC) or a deterministic approach (SCA); the algorithm is shown to be faster. It also has the advantage that it can graphically show a detailed `defect sensitivity map' that can assist a chip designer in improving the yield of his/her layout     

Sequential use of intravenous and oral acyclovir in the therapy of varicella in immunocompromised children

BACKGROUND: Immunocompromised children are at risk for disseminated varicella infections. Standard management involves hospitalization and intravenous acyclovir for 7 to 10 days. This approach is expensive, is inconvenient and may not be necessary. We undertook a pilot study to assess the safety and efficacy of an alternative approach that utilized a combination of intravenous (i.v.) followed by oral (p.o) acyclovir in a cohort of immunocompromised children. METHODS: The cohort consisted of 26 immunocompromised children between the ages of 1.5 and 12.7 years (mean, 6.3). Therapy was commenced with i.v. acyclovir (1500 mg/m2/day in 3 divided doses). Concurrent management included holding or reducing immunosuppressive therapy (by 50%) and administering varicella-zoster immunoglobulin in 69% (11 of 16) of cases where exposure to chickenpox was recognized. Patients were eligible to switch to p.o therapy after receiving a minimum of 48 h of i.v. acyclovir therapy provided they were afebrile; had no new lesions for 24 h; had no internal organ involvement and were able to tolerate oral medications. Patients were observed in hospital for a further 24 h and then discharged provided they remained well. Oral acyclovir was continued for a total of 7 to 10 days (i.v. plus p.o). RESULTS: Of the 26 patients 25 were successfully switched from i.v. to p.o after 4.1 +/- 1.2 days (mean +/- SD) (range, 2.3 to 6) Children had fever for a mean of 2.0 +/- 1.6 days (range, 0 to 5) and developed new lesions for 2.9 +/- 0.7 days (range, 2 to 4). All 25 patients switched to p.o therapy had resolution of their disease and no patient required resumption of i.v. therapy. CONCLUSIONS: The sequential use of i.v. followed by p.o acyclovir is feasible in the treatment of varicella in immunocompromised children and results in a reduction in duration of intravenous therapy and hospitalization.