Using Latent Trait Modeling to Conceptualize an Alcohol Problems Continuum.

Recent research points toward the viability of conceptualizing alcohol problems as arrayed along a continuum. Nevertheless, modern statistical techniques designed to scale multiple problems along a continuum (latent trait modeling; LTM) have rarely been applied to alcohol problems. This study applies LTM methods to data on 110 problems reported during in-person interviews of 1,348 middle-aged men (mean age=43) from the general population. The results revealed a continuum of severity linking the 110 problems, ranging from heavy and abusive drinking, through tolerance and withdrawal, to serious complications of alcoholism. These results indicate that alcohol problems can be arrayed along a dimension of severity and emphasize the relevance of LTM to informing the conceptualization and assessment of alcohol problems. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Identifying Psychopathy Subtypes on the Basis of Personality Structure.

The authors used model-based cluster analysis to identify subtypes of criminal psychopaths on the basis of differences in personality structure. Participants included 96 male prisoners diagnosed as psychopathic, using the Psychopathy Checklist Revised (PCL-R; R. D. Hare, 1991). Personality was assessed using the brief form of the Multidimensional Personality Questionnaire (MPQ-BF; C. J. Patrick, J. J. Curtin, & A. Tellegen, 2002). The best-fitting model yielded two clusters. Emotionally stable psychopaths were characterized by low Stress Reaction and high Agency. Aggressive psychopaths were characterized by high Negative Emotionality, low Constraint, and low Communion. These results suggest that psychopaths as defined by the PCL-R includes distinct subtypes, distinguishable in terms of personality structure, that may reflect different etiologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Insight into the Impact of Oxidative Stress on the Barrier Properties of Lipid Bilayer Models

As a new field of oxidative stress-based therapy, cold physical plasma is a promising tool for several biomedical applications due to its potential to create a broad diversity of reactive oxygen and nitrogen species (RONS). Although proposed, the impact of plasma-derived RONS on the cell membrane lipids and properties is not fully understood. For this purpose, the changes in the lipid bilayer functionality under oxidative stress generated by an argon plasma jet (kINPen) were investigated by electrochemical techniques. In addition, liquid chromatography-tandem mass spectrometry was employed to analyze the plasma-induced modifications on the model lipids. Various asymmetric bilayers mimicking the structure and properties of the erythrocyte cell membrane were transferred onto a gold electrode surface by Langmuir-Blodgett/Langmuir-Schaefer deposition techniques. A strong impact of cholesterol on membrane permeabilization by plasma-derived species was revealed. Moreover, the maintenance of the barrier properties is influenced by the chemical composition of the head group. Mainly the head group size and its hydrogen bonding capacities are relevant, and phosphatidylcholines are significantly more susceptible than phosphatidylserines and other lipid classes, underlining the high relevance of this lipid class in membrane dynamics and cell physiology.     

Descriptive matrix factorization for sustainability Adopting the principle of opposites

Climate change, the global energy footprint, and strategies for sustainable development have become topics of considerable political and public interest. The public debate is informed by an exponentially growing amount of data and there are diverse partisan interest when it comes to interpretation. We therefore believe that data analysis methods are called for that provide results which are intuitively understandable even to non-experts. Moreover, such methods should be efficient so that non-experts users can perform their own analysis at low expense in order to understand the effects of different parameters and influential factors. In this paper, we discuss a new technique for factorizing data matrices that meets both these requirements. The basic idea is to represent a set of data by means of convex combinations of extreme data points. This often accommodates human cognition. In contrast to established factorization methods, the approach presented in this paper can also determine over-complete bases. At the same time, convex combinations allow for highly efficient matrix factorization. Based on techniques adopted from the field of distance geometry, we derive a linear time algorithm to determine suitable basis vectors for factorization. By means of the example of several environmental and developmental data sets we discuss the performance and characteristics of the proposed approach and validate that significant efficiency gains are obtainable without performance decreases compared to existing convexity constrained approaches.     

Convex Relaxation of a Class of Vertex Penalizing Functionals

We investigate a class of variational problems that incorporate in some sense curvature information of the level lines. The functionals we consider incorporate metrics defined on the orientations of pairs of line segments that meet in the vertices of the level lines. We discuss two particular instances: One instance that minimizes the total number of vertices of the level lines and another instance that minimizes the total sum of the absolute exterior angles between the line segments. In case of smooth level lines, the latter corresponds to the total absolute curvature. We show that these problems can be solved approximately by means of a tractable convex relaxation in higher dimensions. In our numerical experiments we present preliminary results for image segmentation, image denoising and image inpainting.     

Parametric Fires for Structural Design

The authorities, the construction association, and a number of companies in Denmark have supported the author writing a guide for design of building structures for parametric fires. The guide is published by the ministry as a supplement to the building regulations. However, consultants and contractors have asked for a reference in English in order to make the guide-lines and the background for them available internationally. The paper therefore presents recommendations from the design guide especially concerning how to assess parametric design fires based on the opening factor method for large compartments. Findings leading to the guide-lines are discussed, and it is indicated what a safe design fire model means for structural design and how it differs from a safe design fire model for evacuation. Furthermore, the paper includes some experiences from the application of the design guide in practise especially concerning implementation of consequences of the latest development of the building technology, where low-energy windows and step-noise damping give rise to changes of the design fires.     

Optimization of bistable viscoelastic systems

We consider the flow of a viscoelastic fluid in a symmetric cross geometry. For small driving pressures the flow is symmetric, but beyond a certain critical pressure the symmetric flow becomes unstable; two stable asymmetric solutions appear, and forcing of the unstable symmetric flow beyond the critical pressure gives rise to increased hydraulic resistance. We have combined a state-of-the-art implementation for viscoelastic flow modeling with topology optimization in a high level finite element package (COMSOL). We use this framework on the cross geometry with the aim to reduce the critical driving pressure corresponding to the point of bistability, such that the effect is enhanced. The point of bistability is, however, not explicitly contained in the solution, so we opt for a heuristic approach based on the dissipation ratio between the asymmetric and unstable symmetric flow solutions. We find a design that significantly reduces the driving pressure required for bistability, and furthermore is in agreement with the approach followed by experimental researchers. Furthermore, by comparing the two asymmetric solutions, we succesfully apply the same approach to a problem with two fluids meeting in the cross.