Implications of proxy caching for provisioning networks and servers

In this paper, we examine the potential benefits of Web proxy caches in improving the effective capacity of servers and networks. Since networks and servers are typically provisioned based on a high percentile of the load, we focus on the effects of proxy caching on the tail of the load distribution. We find that, unlike their substantial impact on the average load, proxies have a diminished impact on the tail of the load distribution. The exact reduction in the tail and the corresponding capacity savings depend on the nature of the workload and the percentile of the load distribution chosen for provisioning networks and servers-the higher the percentile, the smaller the savings. For workloads considered in this study, compared with over a 50% reduction in the average load, the savings in network and server capacity was only 20%-35% for the 99th percentile of the load distribution. We also find that while proxies can be somewhat useful in smoothing out some of the burstiness in Web workloads; the resulting workload continues, however, to exhibit substantial burstiness and a heavy-tailed nature. We identify one-time requests for large objects to be the limiting factor that diminishes the impact of proxies on the tail of load distribution. We conclude that, while proxies are immensely useful to users due to the reduction in the average response time, they are less effective in improving the capacities of networks and servers.     

Platelet and neutrophil distributions in pump oxygenator circuits. III. Influence of nitric oxide gas infusion

The authors used quantitative gamma scintigraphy to evaluate the influence of nitric oxide gas on platelet and neutrophil deposition in Cobe Duo microporous oxygenators during cardiopulmonary bypass (CPB). The effects of nitric oxide gas on circulating platelet and neutrophil counts and platelet function also were assessed. Animals were prepared by standard methods. Cells were harvested, labeled (111 In platelet and 99mTc neutrophil), infused, and recirculated. Nitric oxide gas, a guanylate cyclase pathway promoter, was infused int he Duo gas port at 500 ppm (t = 0-60 min), increased to 1,000 (t = 60-80 min), and stopped (final, 10 min). Images were taken at 10-15 min intervals during CPB. Standard isotope image corrections were made. No differences between nitric oxide gas and control experiments were observed for flow, pressure, hematocrit, or replacement volume. Nitric oxide gas infusion significantly (p < 0.05) reduced both platelet adherence to the oxygenator and in vitro platelet aggregation. Neutrophil adhesion tended to be lower, and circulating platelet and neutrophil counts tended to be higher with nitric oxide gas infusion. Results of in vitro aggregometry studies using rabbit platelets indicate that the class V phosphodiesterase inhibitor zaprinast can strongly enhance the inhibitory effects of nitric oxide. The authors conclude nitric oxide gas is a promising platelet sparing agent in the setting of CPB.     

Depth-Resolved Porosity Investigation of EB-PVD Thermal Barrier Coatings Using High-Energy X-rays

Demands for designing prime reliant, energy-efficient, and high-performance thermal barrier coatings (TBCs) in gas turbines have led to a growing interest toward comprehensive microstructural characterization. Here we investigate the novel use of high-energy X-rays for small-angle X-ray scattering (SAXS), together with wide-angle scattering and radiography, for the depth-resolved characterization of TBCs grown by electron beam physical vapor deposition (EB-PVD). The coating microstructure is found to consist of columns perpendicular to the substrate, extending through the thickness, with a [001] growth texture and significant intercolumnar porosity. In addition, overshadowing effects during deposition together with gas entrapment give rise to nanoscale intracolumnar porosity consisting of featherlike and globular pores. Radiography showed an increase in the total porosity, from 15% near the substrate to 25% near the coating surface, which is ascribed to an increase in the intercolumnar spacing at the top of the coating. By contrast, the small-angle scattering studies, which are sensitive to fine features, showed the pore internal surface area to be greatest near the substrate.     

A dynamic model for predicting the motion of solder droplets during assembly

The dynamic motion of a solder droplet during assembly is a complex, unsteady, free surface problem involving surface tension and viscous effects. The motion of the droplet is coupled with the motion of the component or chip to be assembled and involves dynamic contact lines. A methodology based on a non-uniform rational b-spline (NURBS) discretization has been developed for the dynamic analysis of the droplet motion. A surface energy based formulation has been developed to incorporate the surface tension effects. The developed methodology leads to an updated Lagrangian scheme with a Galerkin in space and Least square in time formulation. The NURBS representation used for the spatial discretization enables the method to handle problems involving complex droplet geometries. The ability of the NURBS representation to provide both global and local control, along with the least square method used in this methodology, enables us to develop an unconditionally stable time integration scheme which can be optimized to achieve desired accuracy and numerical dissipation efficiently. A sample problem of droplet shape evolution has been solved to demonstrate the path prediction capability of the proposed methodology. In future, the method can be applied to solve various real world dynamic motion problems associated with droplets.     

Electrodialytic transport properties of heterogeneous cation‐exchange membranes prepared by gelation and solvent evaporation methods

The heterogeneous cation‐exchange membranes were prepared by employing two different methods: immersing the cation‐exchange resin‐loaded membranes in gelation bath; evaporating the solvent upon casting a uniform solution of cation‐exchange resin on a glass plate. The effect of resin loading on the electrochemical properties of the membranes was evaluated. The permselectivity of these heterogeneous membranes and transport number of calcium ions relative to sodium ions was evaluated with respect to the extent of resin loading and the methods of preparation. It is found that the membrane potential, transport number, permselectivity, and relative transport number are prominently high in the solvent evaporation method compared with the gelation method. The transport number of calcium ions relative to sodium ions in the solvent evaporation method increased monotonously with increasing resin loading. However, the increase of resin loading did not influence much on the relative transport numbers in the gelation method. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 198–207, 2006     

Degraded Gaussian multirelay channel: capacity and optimal power allocation

We determine the capacity region of a degraded Gaussian relay channel with multiple relay stages. This is done by building an inductive argument based on the single-relay capacity theorem of Cover and El Gamal. For an arbitrary distribution of noise powers, we derive the optimal power distribution strategy among the transmitter and the relays and the best possible improvement in signal-to-noise ratio (SNR) that can be achieved from using a given number of relays. The time-division multiplexing operation of the relay channel in the wideband regime is analyzed and it is shown that time division does not achieve minimum energy per bit.     

Importance of protein kinase C for normal development of transmitter release properties in embryonic chick sympathetic neurons in culture

Three new dammarane-type triterpenoid saponins, bacopasaponins A, B and C, of biological interest have been isolated from the reputed Indian medicinal plant Bacopa monniera and identified as 3-O-alpha-L-arabinopyranosyl-20-O-alpha-L-arabinopyranosyl-+ ++jujubogenin, 3-O-[alpha-L-arabinofuranosyl (1--> 2)alpha-L-arabinopyranosyl]pseudojujubogenin and 3-O-[beta-D-glucopyranosyl (1 -->3)[alpha-L-arabinofuranosyl (1--> 2)]alpha-L-arabinopyranosyl]pseudojujubogenin by spectroscopic methods and some chemical transformations. The hitherto undetermined configurations at C-20 and C-22 of pseudojujubogenin were elucidated by phase-sensitive ROESY, and 1H and 13C signals of the saponins were assigned by DEPT, 1H-1H COSY, HSQC and HMBC techniques.