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Sebastian Riedle Laetitia C. Pele Don E. Otter Rachel E. Hewitt Harjinder Singh Nicole C. Roy Jonathan J. Powell 《Particle and fibre toxicology》2017,14(1):51
Background
Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma?/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan.Given the variance in human genotypes, which includes variance in genes related to IL-1β secretion, we investigated whether TiO2 particles might, in fact, be more potent pro-inflammatory adjuvants in cells that are genetically susceptible to IL-1β-related inflammation.Methods
We studied bone marrow-derived macrophages from mice with a mutation in the nucleotide-binding oligomerisation domain-containing 2 gene (Nod2 m/m), which exhibit heightened secretion of IL-1β in response to the peptidoglycan fragment muramyl dipeptide (MDP). To ensure relevance to human exposure, TiO2 was food-grade anatase (119?±?45 nm mean diameter?±?standard deviation). We used a short ‘pulse and chase’ format: pulsing with LPS and chasing with TiO2 +/? MDP or peptidoglycan.Results
IL-1β secretion was not stimulated in LPS-pulsed bone marrow-derived macrophages, or by chasing with MDP, and only very modestly so by chasing with peptidoglycan. In all cases, however, IL-1β secretion was augmented by chasing with TiO2 in a dose-dependent fashion (5–100 μg/mL). When co-administered with MDP or peptidoglycan, IL-1β secretion was further enhanced for the Nod2 m/m genotype. Tumour necrosis factor α was triggered by LPS priming, and more so for the Nod2 m/m genotype. This was enhanced by chasing with TiO2, MDP, or peptidoglycan, but there was no additive effect between the bacterial fragments and TiO2.Conclusion
Here, the doses of TiO2 that augmented bacterial fragment-induced IL-1β secretion were relatively high. In vivo, however, selected intestinal cells appear to be loaded with TiO2, so such high concentrations may be ‘exposure-relevant’ for localised regions of the intestine where both TiO2 and bacterial fragment uptake occurs. Moreover, this effect is enhanced in cells from Nod2 m/m mice indicating that genotype can dictate inflammatory signalling in response to (nano)particle exposure. In vivo studies are now merited.33.
A resilient, thermosetting foam system with a bio‐based content of 96 wt % (resulting in 81% of C14) was successfully developed. We implemented a pressurized carbon dioxide foaming process that produces polymeric foams from acrylated epoxidized soybean oil (AESO). A study of the cell dynamics of uncured CO2/ AESO foams proved useful to optimize cure conditions. During collapse, the foam's bulk density increased linearly with time, and the cell size and cell density exhibited power‐law degradation rates. Also, low temperature foaming and cure (i.e. high viscosity) are desirable to minimize foam cell degradation. The AESO was cured with a free‐radical initiator (tert‐butyl peroxy‐2‐ethyl hexanoate, Ti ~ 60°C). Cobalt naphtenate was used as an accelerator to promote quick foam cure at lower temperature (40–50°C). The foam's density was controlled by the carbon dioxide pressure inside the reactor and by the vacuum applied during cure. The viscosity increased linearly during polymerization. The viscosity was proportional to the extent of reaction before gelation, and the cured foam's structure showed a dependence on the time of vacuum application. The average cell size increased and the cell density decreased with foam expansion at a low extent of cure; however, the foam expansion became limited and unhomogeneous with advanced reaction. When vacuum was applied at an intermediate viscosity, samples with densities ~ 0.25 g/cm3 were obtained with small (<1 mm) homogeneous cells. The mechanical properties were promising, with a compressive strength of ~ 1 MPa and a compressive modulus of ~ 20 MPa. The new foams are biocompatible. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 2007 相似文献
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Laetitia Petroni Michel Boussuge David Ryckelynck 《Journal of the European Ceramic Society》2012,32(15):3941-3947
This study concerns high zirconia fused-cast refractories used in the glass industry. In situ temperature measurements have been performed in the casting structure during an actual casting of a tile. A two-dimensional mesh of the casting structure has been developed so as to perform numerical simulations. From temperature recordings, an interfacial heat transfer coefficient between the tile and the graphite mould has been determined, by an inverse method, by fitting the calculated temperatures with those measured. A similar procedure allowed the thermal conductivity and the heat capacity of the surrounding insulating medium to be determined. Then, the numerical model allowed the evolution of the temperature field, within the tile, to be determined. The influences of different parameters (mould thickness and thermal properties of the annealing medium) have been numerically tested, by comparison with the cooling-down kinetics of the tile. 相似文献
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Laetitia Patural Jean-Pierre Korb Alexandre Govin Philippe Grosseau Bertrand Ruot Olivier Devès 《Cement and Concrete Research》2012,42(10):1371-1378
We show how nuclear magnetic spin–lattice relaxation dispersion of proton-water (NMRD) can be used to elucidate the effect of cellulose ethers on water retention and hydration delay of freshly-mixed white cement pastes. NMRD is useful to determine the surface diffusion coefficient of water, the specific area and the hydration kinetics of the cement-based material. In spite of modifications of the solution's viscosity, we show that the cellulosic derivatives do not modify the surface diffusion coefficient of water. Thus, the mobility of water present inside the medium is not affected by the presence of polymer. However, these admixtures modify significantly the surface fraction of mobile water molecules transiently present at solid surfaces. This quantity measured, for the first time, for all admixed cement pastes is thus relevant to explain the water retention mechanism. 相似文献
37.
Implementation of metal-free ring-opening polymerization in the preparation of aliphatic polycarbonate materials 总被引:1,自引:0,他引:1
Laetitia Mespouille Olivier Coulembier Michal Kawalec Andrew P. Dove Philippe Dubois 《Progress in Polymer Science》2014
Environmental concerns along with the need to develop aliphatic polycarbonate materials free of any toxic compounds have driven scientists to implement macromolecular engineering processes by replacing potentially toxic and carcinogenic metal-based catalysts traditionally used for the ring-opening polymerization of cyclic carbonates by organic compounds. This issue is of particular importance as aliphatic polycarbonates are gaining increasing credibility for biomedical applications owing to their biocompatibility and bioresorbability. This review provides a complete account of the various metal-free catalysts that has been developed so far as well as comprehensive investigations on the related polymerization mechanisms. 相似文献
38.
A pulsed field gradient and NMR imaging investigations of the water retention mechanism by cellulose ethers in mortars 总被引:1,自引:0,他引:1
Laetitia Patural Patrice Porion Alexandre Govin Bertrand Ruot 《Cement and Concrete Research》2010,40(9):1378-1385
The study presented in this paper is devoted to improve the knowledge on the influence of cellulose ethers (CE) on the freshly-mixed mortars water retention. Indeed, this crucial property is the most important imparted by these polysaccharides. One of the assumptions proposed to explain this phenomenon is that CE acts as diffusion barrier to the water. To test this hypothesis, the CE effect on the self-diffusion coefficient of water in solution and on the water mobility between two fresh cement pastes was studied by Nuclear Magnetic Resonance. CE does not significantly modify the water self-diffusion coefficient in CE solution or in admixed cement pastes. Moreover the interdiffusion imaging experiments demonstrated that the water diffusion at the paste/paste interface is not affected by the presence of cellulosic admixture. 相似文献
39.
Laure Monnereau Laetitia Urbanczyk Jean-Michel Thomassin Michaël Alexandre Christine Jérôme Isabelle Huynen Christian Bailly Christophe Detrembleur 《Polymer》2014
Supercritical carbon dioxide readily induced foaming of various polymers. In that context, supercritical CO2 was applied to carbon nanotubes based polycarbonate nanocomposites to ensure their foaming. Surprisingly, efficient foaming only occurs when low pressure is applied while at high pressure, no expansion of the samples was observed. This is related to the ability of supercritical carbon dioxide to induce crystallization of amorphous polycarbonate. Moreover, this behaviour is amplified by the presence of carbon nanotubes that act as nucleating agents for crystals birth. The thermal behaviour of the composites was analysed by DSC and DMA and was related to the foaming observations. The uniformity of the cellular structure was analysed by scanning electron microscopy (SEM). By saturating the polycarbonate nanocomposites reinforced with 1 wt% of MWNTs at 100 bar and 100 °C during 16 h, microcellular foams were generated, with a density of 0.62, a cell size ranging from 0.6 to 4 μm, and a cellular density of 4.1 × 1011 cells cm−3. The high ability of these polymeric foams to absorb electromagnetic radiation was demonstrated at low MWNT content as the result of the high affinity of the polycarbonate matrix for MWNTs, and therefore to the good MWNTs dispersion. 相似文献
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