Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Research on the Mechanical Properties of Magnetorheological Damping and the Performance of Microprobe Test Process

Journal of Electronic Testing - In order to control the stable and controllable loading of the wafer level microprobe test bench, the magnetorheological (MR) damper used in the existing research...     

The effect of curing on the crystallization of poly(phenylene sulfide)

Summary Poly(phenylene sulfide) (PPS) was cured in the melt and solid states under air and/or nitrogen environments. Crystallization behavior of such cured materials as a function of cure time at 320°C and 255°C was studied via differential scanning calorimetry. It was found, on general, that while short-time curing leads to an increase in crystallization rate, prolonged curing leads to a decrease in both crystallinity and crystallization rate. In contrast to the enhanced crystallization rate caused by curing in nitrogen at the melt state, no significant change of crystallization rate is observed while curing is done in the solid state (in nitrogen).     

An axiom system for sequence-based specification

This paper establishes an axiomatic foundation and a representation theorem for the rigorous, constructive process, called sequence-based specification, of deriving precise specifications from ordinary (informal) statements of functional requirements. The representation theorem targets a special class of Mealy state machines, and algorithms are presented for converting from the set of sequences that define the specification to the equivalent Mealy machine, and vice versa. Since its inception, sequence-based specification has been effectively used in a variety of real applications, with gains reported in quality and productivity. This paper establishes the mathematical foundation independently of the process itself.     

一种基于可信度矩阵的多传感器目标识别方法

为了解决多传感器目标识别中不同等级信息源数据的融合问题,在研究DSmT证据理论的基础上,引入证据可信度矩阵.依据可信度矩阵对证据进行转化,使之可以用传统的方法进行证据融合.将这种方法应用到等级不同的多传感器目标识别中,可以解决传统证据理论只能进行相同等级传感器目标识别的难题.仿真实验表明,该方法提高了目标识别的准确性和有效性.     

一种基于自适应量化嵌入器的隐写方法

感知质量和容量一直是图像隐写算法设计中难以折中的两个要素,如何取得更好的综合性能已吸引了很多研究者的兴趣.提出一种基于自适应量化嵌入器的隐写方法.这一方法通过改变某一载体信号所在子空间的索引来调制秘密信息,自适应特性体现在决定着子空间尺寸的分割码本的设计上.将这种隐写方法用于以2×2图像块为单元的数字图像隐写算法设计中,并将分割码本设计得具备HVS特性以取得较好的折中效果.实验表明,算法在感知质量和容量方面具有较好的综合性能.     

Group interaction analysis in dynamic context.

Computer understanding of human actions and interactions is one of the key research issues in human computing. In this regard, context plays an essential role in semantic understanding of human behavioral and social signals from sensor data. This paper put forward an event-based dynamic context model to address the problems of context awareness in the analysis of group interaction scenarios. Event-driven multilevel dynamic Bayesian network is correspondingly proposed to detect multilevel events, which underlies the context awareness mechanism. Online analysis can be achieved, which is superior over previous works. Experiments in our smart meeting room demonstrate the effectiveness of our approach.     

多级故障诊断系统

介绍了为提高故障诊断的正确率,将一混合故障诊断专家系统中的基于BP神经网络诊断模块、基于自组织神经网络诊断模块和基于小波分析诊断模块设计成多级诊断系统。对多级诊断系统的性能进行了分析,给出了多级诊断系统的拒绝输出策略。