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71.
This paper presents an agent-based model of an organization. The model is made of a social network—composed of the different organization workers—and a knowledge network. Workers are assigned tasks, for which they have to use information in the knowledge network. We have modeled the quality of the information by assigning each information item a probability of being wrong. Agents can interact with other agents, who can recommend to them new information items in the knowledge network for the task to be performed. Workers are assigned different information-seeking behavior (passive, active, and learning), governing the way in which they interact with each other. Moreover, indirect interaction is also possible, as a publicly accessible knowledge base contains each agent's preferred information items. The model was implemented in SDML, and its simulation shows that agents quickly learn to discern the better information items for the given task. However, group formation (agents' collaborating by exchanging information) takes longer to stabilize. Additionally, when the quality of items is changed, agents can quickly select the better new knowledge items, and organization performance improves again to a maximum that is only randomly disturbed. 相似文献
72.
73.
Lara Schmitt Stéphanie Buisine Jonathan Chaboissier Améziane Aoussat Frédéric Vernier 《Computers in human behavior》2012
We designed a tabletop brainwriting interface to examine the effects of time pressure and social pressure on the creative performance. After positioning this study with regard to creativity research and human activity in dynamic environments, we present our interface and experiment. Thirty-two participants collaborated (by groups of four) on the tabletop brainwriting task under four conditions of time pressure and two conditions of social pressure. The results show that time pressure increased the quantity of ideas produced and, to some extent, increased the originality of ideas. However, it also deteriorated user experience. Besides, social pressure increased quantity of ideas as well as motivation, but decreased collaboration. We discuss the implications for creativity research and Human–Computer Interaction. Anyhow, our results suggest that the Press factor, operationalized by Time- or Social-pressure, should be considered as a powerful lever to enhance the effectiveness of creative problem solving methods. 相似文献
74.
This paper presents the combined use of meta-modelling and graph grammars for the generation of visual modelling tools for simulation formalisms. In meta-modelling, formalisms are described at a meta-level. This information is used by a meta-model processor to generate modelling tools for the described formalisms. We combine meta-modelling with graph grammars to extend the model manipulation capabilities of the generated modelling tools: edit, simulate, transform into another formalism, optimize and generate code. We store all (meta-)models as graphs, and thus, express model manipulations as graph grammars.We present the design and implementation of these concepts in AToM3 (A_To_ol for M_ulti-formalism, M_eta-M_odelling). AToM3 supports modelling of complex systems using different formalisms, all meta-modelled in their own right. Models in different formalisms may be transformed into a single common formalism for further processing. These transformations are specified by graph grammars. Mosterman and Vangheluwe [18] introduced the term multi-paradigm modelling to denote the combination of multiple formalisms, multiple abstraction levels, and meta-modelling. As an example of multi-paradigm modelling we present a meta-model for the Object-Oriented Continuous Simulation Language OOCSMP, in which we combine ideas from UML class diagrams (to express the OOCSMP model structure), Causal Block Diagrams (CBDs), and Statecharts (to specify the methods of the OOCSMP classes). A graph grammar is able to generate OOCSMP code, and then a compiler for this language (C-OOL) generates Java applets for the simulation execution. 相似文献
75.
Model transformations are central components of most model-based software projects. While ensuring their correctness is vital to guarantee the quality of the solution, current transformation tools provide limited support to statically detect and fix errors. In this way, the identification of errors and their correction are nowadays mostly manual activities which incur in high costs. The aim of this work is to improve this situation. Recently, we developed a static analyser that combines program analysis and constraint solving to identify errors in ATL model transformations. In this paper, we present a novel method and system that uses our analyser to propose suitable quick fixes for ATL transformation errors, notably some non-trivial, transformation-specific ones. Our approach supports speculative analysis to help developers select the most appropriate fix by creating a dynamic ranking of fixes, reporting on the consequences of applying a quick fix, and providing a pre-visualization of each quick fix application. The approach integrates seamlessly with the ATL editor. Moreover, we provide an evaluation based on existing faulty transformations built by a third party, and on automatically generated transformation mutants, which are then corrected with the quick fixes of our catalogue. 相似文献
76.
This work is devoted to the experimental investigation and theoretical modeling of biological products with high initial moisture content which implies significant volume contraction. Firstly, experimental equipment which was designed to continuously determine variations in the global moisture content and in the temperature of the sample is introduced. Furthermore, the equipment is controlled by a PC which records experimental information in real time. In particular, measurement of the radial and temporal distributions of moisture content and temperature during the drying process of the homogeneous porous media potato are given. The mean moisture content and temperature curves are also given. 相似文献
77.
Lara Naurath Christoph Weidner Thomas R. Rüde Andre Banning 《Mine Water and the Environment》2011,30(3):231-236
Sodium fluorescein (uranine) is one of the most popular fluorescent dyes for tracer experiments due to its chemical properties,
low detection limits and low costs. As a limiting factor, it is generally assumed that Na-fluorescein cannot be properly detected
under acid conditions because of weak fluorescence intensities at the standard excitation wavelength (490 nm). This laboratory
study introduces a method to quantify Na-fluorescein in low pH waters without having to raise pH to alkaline conditions, which
spares the time- and cost-intensive filtration of hydroxide precipitates prior to analysis. It was applied for recovery tests
in water samples from five mining sites in Germany. These were buffered to pH 1.5 where Na-fluorescein shows a second fluorescence
intensity maximum at an excitation wavelength of 438 nm. The method had satisfying recovery rates although, as expected, a
higher detection limit compared to standard wavelength and pH. High Fe contents in the waters are a limiting factor—the impact
of increasing Fe concentrations at a constant dye spike was evaluated and yielded a distinct negative trend between Fe and
detected Na-fluorescein, probably due to Fe-fluorescein complexation. However, good recovery can be expected in mine waters
with up to ≈100 mg L−1 Fe. The method of standard addition offers a potential calculative solution for higher Fe concentrations, resulting in significantly
better Na-fluorescein recovery rates, compared to direct measurements. The method introduced here represents a promising approach
for improving Na-fluorescein applicability in acid environments. 相似文献
78.
River fragmentation is a process highly detrimental for fish survival by impeding their migrations. Although fragmentation by big dams has been studied, there is still a big deficiency of data related to small barriers. This study was designed as a detailed, local-scale analysis of several chosen river stretches in the Sandomierz Basin, Poland. It aimed to: (1) map all natural and artificial barriers in the study area, (2) assess the impacts of these barriers on fish migration, (3) compare findings to existing databases, and (4) make recommendations for improved barrier management. Ten lowland rivers covering a total 424 km length were surveyed by river walkovers and kayak surveys, with all the barriers mapped and all the artificial structures assessed for fish migration using the ICE protocol protocol for ecological continuity. There were 67 beaver dams and 89 artificial barriers recorded, with only 24% of the latter being included in national databases. The average artificial barrier density in all the surveyed rivers was 0.2 barriers/km and varied from 0.75 barriers/km in first order streams to 0.01 barriers/km in sixth order river. The findings revealed that 18% of the barriers were passable for all fish species, with 35% totally impassable. The analysis of specific barrier parameters indicated that water depth at the barrier had a greater influence on fish passability than the barrier height. Several barriers were proposed for removal to specifically improve the potential for fish migration. 相似文献
79.
Nuno Vale Mariana Pereira Joana Santos Catarina Moura Lara Marques Diana Duarte 《International journal of molecular sciences》2023,24(1)
Chemotherapy is the main treatment for most early-stage cancers; nevertheless, its efficacy is usually limited by drug resistance, toxicity, and tumor heterogeneity. Cell-penetrating peptides (CPPs) are small peptide sequences that can be used to increase the delivery rate of chemotherapeutic drugs to the tumor site, therefore contributing to overcoming these problems and enhancing the efficacy of chemotherapy. The drug combination is another promising strategy to overcome the aforementioned problems since the combined drugs can synergize through interconnected biological processes and target different pathways simultaneously. Here, we hypothesized that different peptides (P1–P4) could be used to enhance the delivery of chemotherapeutic agents into three different cancer cells (HT-29, MCF-7, and PC-3). In silico studies were performed to simulate the pharmacokinetic (PK) parameters of each peptide and antineoplastic agent to help predict synergistic interactions in vitro. These simulations predicted peptides P2–P4 to have higher bioavailability and lower Tmax, as well as the chemotherapeutic agent 5-fluorouracil (5-FU) to have enhanced permeability properties over other antineoplastic agents, with P3 having prominent accumulation in the colon. In vitro studies were then performed to evaluate the combination of each peptide with the chemotherapeutic agents as well as to assess the nature of drug interactions through the quantification of the Combination Index (CI). Our findings in MCF-7 and PC-3 cancer cells demonstrated that the combination of these peptides with paclitaxel (PTX) and doxorubicin (DOXO), respectively, is not advantageous over a single treatment with the chemotherapeutic agent. In the case of HT-29 colorectal cancer cells, the combination of P2–P4 with 5-FU resulted in synergistic cytotoxic effects, as predicted by the in silico simulations. Taken together, these findings demonstrate that these CPP6-conjugates can be used as adjuvant agents to increase the delivery of 5-FU into HT-29 colorectal cancer cells. Moreover, these results support the use of in silico approaches for the prediction of the interaction between drugs in combination therapy for cancer. 相似文献
80.
Petra Buri Ivana arapar Dijana Pavi
i-Hamer Ines Kova
i Lara Jurkovi Maja Dutour Sikiri Darija Domazet Jurain Nevenka Mikac Niko Ba
i Daniel Mark Lyons 《International journal of molecular sciences》2023,24(1)
Silver nanoparticles represent a threat to biota and have been shown to cause harm through a number of mechanisms, using a wide range of bioassay endpoints. While nanoparticle concentration has been primarily considered, comparison of studies that have used differently sized nanoparticles indicate that nanoparticle diameter may be an important factor that impacts negative outcomes. In considering this, the aim of the present study was to determine if different sizes of silver nanoparticles (AgNPs; 10, 20, 40, 60 and 100 nm) give rise to similar effects during embryogenesis of Mediterranean sea urchins Arbacia lixula and Paracentrotus lividus, or if nanoparticle size is a parameter that can modulate embryotoxicity and spermiotoxicity in these species. Fertilised embryos were exposed to a range of AgNP concentrations (1–1000 µg L−1) and after 48 h larvae were scored. Embryos exposed to 1 and 10 µg L−1 AgNPs (for all tested sizes) showed no negative effect in both sea urchins. The smaller AgNPs (size 10 and 20 nm) caused a decrease in the percentage of normally developed A. lixula larvae at concentrations ≥50 µg L−1 (EC50: 49 and 75 μg L−1, respectively) and at ≥100 µg L−1 (EC50: 67 and 91 μg L−1, respectively) for P. lividus. AgNPs of 40 nm diameter was less harmful in both species ((EC50: 322 and 486 μg L−1, for P. lividus and A. lixula, respectively)). The largest AgNPs (60 and 100 nm) showed a dose-dependent response, with little effect at lower concentrations, while more than 50% of larvae were developmentally delayed at the highest tested concentrations of 500 and 1000 µg L−1 (EC50(100 nm); 662 and 529 μg L−1, for P. lividus and A. lixula, respectively. While AgNPs showed no effect on the fertilisation success of treated sperm, an increase in offspring developmental defects and arrested development was observed in A. lixula larvae for 10 nm AgNPs at concentrations ≥50 μg L−1, and for 20 and 40 nm AgNPs at concentrations >100 μg L−1. Overall, toxicity was mostly ascribed to more rapid oxidative dissolution of smaller nanoparticles, although, in cases, Ag+ ion concentrations alone could not explain high toxicity, indicating a nanoparticle-size effect. 相似文献