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151.
152.
Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
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155.
Chinh Ngo Radhika Mehta Kanchan Aggarwal Audrey G. Fikes Dr. Ines C. Santos Dr. Sylvester M. Greer Prof. Dr. Emily L. Que 《Chembiochem : a European journal of chemical biology》2019,20(8):1003-1007
One-third of all proteins are estimated to require metals for structural stability and/or catalytic activity. Desthiobiotin probes containing metal binding groups can be used to capture metalloproteins with exposed active-site metals under mild conditions so as to prevent changes in metallation state. The proof-of-concept was demonstrated with carbonic anhydrase (CA), an open active site, Zn2+-containing protein. CA was targeted by using sulfonamide derivatives. Linkers of various lengths and structures were screened to determine the optimal structure for capture of the native protein. The optimized probes could selectively pull down CA from red blood cell lysate and other protein mixtures. Pull-down of differently metallated CAs was also investigated. 相似文献
156.
Kooij Julian F. P. Flohr Fabian Pool Ewoud A. I. Gavrila Dariu M. 《International Journal of Computer Vision》2019,127(3):239-262
International Journal of Computer Vision - Anticipating future situations from streaming sensor data is a key perception challenge for mobile robotics and automated vehicles. We address the problem... 相似文献
157.
P. Carrasqueira H. Rocha J. M. Dias T. Ventura B. C. Ferreira M. C. Lopes 《International Transactions in Operational Research》2023,30(1):206-223
Radiation therapy is a technology-driven cancer treatment modality that has experienced significant advances over the last decades, due to multidisciplinary contributions that include engineering and computing. Recent technological developments allow the use of noncoplanar volumetric modulated arc therapy (VMAT), one of the most recent photon treatment techniques, in clinical practice. In this work, an automated noncoplanar arc trajectory optimization framework designed in two modular phases is presented. First, a noncoplanar beam angle optimization algorithm is used to obtain a set of noncoplanar irradiation directions. Then, anchored in these directions, an optimization strategy is proposed to compute an optimal arc trajectory. The computational experiments considered a pool of twelve difficult head-and-neck tumor cases. It was possible to observe that, for some of these cases, the optimized noncoplanar arc trajectories led to significant treatment planning quality improvements, when compared with coplanar VMAT treatment plans. Although these experiments were done in a research environment treatment planning software (matRad), the conclusions can be of interest for a clinical setting: automated procedures can simplify the current treatment workflow, produce high-quality treatment plans, making better use of human resources and allowing for unbiased comparisons between different treatment techniques. 相似文献
158.
Measurement Techniques - A comparative analysis of the results of estimation of measurement uncertainty is conducted. The results are obtained by a method described in the Handbook on the... 相似文献
159.
Tolmachev A. M. Kuznetsova T. A. Fomenkov P. E. 《Protection of Metals and Physical Chemistry of Surfaces》2021,57(3):433-436
Protection of Metals and Physical Chemistry of Surfaces - The conditions for carrying out molecular dynamics calculations of adsorption isotherms of gases and vapors in micropores of active carbons... 相似文献
160.
El-Denglawey A. Issa Shams A. M. Saddeek Yasser B. Tekin H. O. Zakaly Hesham M. H. 《Journal of Inorganic and Organometallic Polymers and Materials》2021,31(10):3934-3942
Journal of Inorganic and Organometallic Polymers and Materials - This work aimed to investigate the impact of Lead-fluoride based glasses via theoretical and simulation techniques on mechanical and... 相似文献