Controlled modification and direct characterization of multimode-fiber refractive-index profiles

A combination of controlled annealing and characterization by scanning probe microscopy (SPM) is used to demonstrate that the refractive-index proffle of a commercially available silica-based optical fiber can be accurately reconfigured for use as an evanescent field sensor. The process relies on the controlled relocation of the silica glass dopants across the fiber cross section through heat treatment and the accurate measurement of the resulting dopant redistribution with SPM and differential etching techniques. The effect of variable annealing along a length of fiber is to produce a mode transformer to couple light from a laser source into the sensing region of the fiber.     

Resonance Raman spectroscopy of photolabile transition metal carbonyls: controlled photoalteration with continuous wave lasers to record spectra of reactants or transient species

A method has been developed that enables resonance Raman spectra of photolabile species in solution to be recorded under conditions where the level of photoalteration is controlled: a low level enables reactant spectra to be recorded, whereas a high level enables the spectra of short-lived transient species to be recorded in real time using continuous-wave (CW) lasers and standard Raman detection equipment. The design includes a sealed flow system, enabling air-sensitive species to be studied under an inert atmosphere. A simple theoretical model has been developed to aid the interpretation of experimental results, and its applicability is demonstrated. Controlled photoalteration and its theory are demonstrated with 413.1-nm excitation of carbonmonoxymyoglobin (MbCO), which generates deoxymyoglobin (deoxy-Mb) on photolysis, and for which the spectra of both species are well established. The methods have also been applied to two air-sensitive, photolabile transition metal carbonyls using 514.5-nm wavelength excitation: for Cp2Mo2(CO)6 (Cp = eta5-C5H5), increasing levels of photoalteration result only in a decrease in the parent band intensities, relative to the solvent bands; for Cp2Fe2(CO)4, increasing levels of photoalteration result in the appearance of additional bands that are assigned to the transient species CpFe(mu-CO)3FeCp, formed following the loss of a CO ligand.     

Atomic resolution of lithium ions in LiCoO2

LiCoO2 is the most common lithium storage material for lithium rechargeable batteries, used widely to power portable electronic devices such as laptop computers. Operation of lithium rechargeable batteries is dependent on reversible lithium insertion and extraction processes into and from the host materials of lithium storage. Ordering of lithium and vacancies has a profound effect on the physical properties of the host materials and the electrochemical performance of lithium batteries. However, probing lithium ions has been difficult when using traditional X-ray and neutron powder diffraction techniques due to lithium's relatively low scattering power when compared with those of oxygen and transition metals. In the work presented here, we have succeeded in simultaneously resolving columns of cobalt, oxygen and lithium atoms in layered LiCoO2 battery material, using experimental focal series of LiCoO2 images obtained at sub-?ngstrom resolution in a mid-voltage transmission electron microscope. Lithium atoms are the smallest and lightest metal atoms, and scatter electrons only very weakly. We believe our observations of lithium to be the first by electron microscopy, and that they show promise for direct visualization of the ordering of lithium and vacancies in transition metal oxides.     

Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans

Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine pathway and of unique structural features in the active site observed by X-ray crystallography, especially in comparison to its human counterpart (TMPKh). Different 5-modified thymidine derivatives, as well as purine and pyrimidine analogues or C-nucleosides were tested on TMPKmt and TMPKh, and the results were rationalized by docking studies. 5-Halogenated 2'-deoxyuridines are the best inhibitors of TMPKmt found and present the highest selectivity indexes in favor of TMPKmt.     

A New Sidelobe Correction Algorithm for Microwave Radiometers: Application to the Envisat Instrument

The antenna temperature measured by a microwave radiometer is converted in brightness temperature (TB) by removing the different contributions that do not come from the main lobe of the antenna. Among them, the Earth contribution in the sidelobes may be significant as for the Environmental Satellite mission due to the antenna position on the platform. In such a case, simple corrections commonly applied on previous altimetry missions are inadequate, and a more accurate correction should be determined. We propose in this paper a new method based on global seasonal tables of contamination. This allows application of an accurate sidelobe correction in space and time in the retrieved TB computation     

成功变革的关键战胜心中的"洞中人"

任何新事物都会遇到抵抗.事情总是这样.每个组织都有一种免疫系统,具备自动袭击任何变化的抗体.     

Design and implementation of a trusted monitoring framework for cloud platforms

Virtualization is a pillar technology in cloud computing for multiplexing computing resources on a single cloud platform for multiple cloud tenants. Monitoring the behavior of virtual machines (VMs) on a cloud platform is a critical requirement for cloud tenants. Existing monitoring mechanisms on virtualized platforms either takes a complete VM as the monitoring granularity, such that they cannot capture the malicious behaviors within individual VMs, or they focus on specific monitoring functions that cannot be used for heterogeneous VMs concurrently running on a single cloud node. Furthermore, the existing monitoring mechanisms have made an assumption that the privileged domain is trusted to act as expected, which causes the cloud tenants’ concern about security because the privileged domain in fact could not act as the tenants’ expectation. We design a trusted monitoring framework, which provides a chain of trust that excludes the untrusted privileged domain, by deploying an independent guest domain for the monitoring purpose, as well as utilizing the trusted computing technology to ensure the integrity of the monitoring environment. Moreover, the feature of fine-grained and general monitoring is also provided. We have implemented the proposed monitoring framework on Xen, and integrated it into OpenNebula. Our experimental results show that it can offer expected functionality, and bring moderate performance overhead.     

Virtual learning environments as sociomaterial agents in the network of teaching practice

This article presents findings related to the sociomaterial agency of educators and their practice in Norwegian education. Using actor-network theory, we ask how Virtual Learning Environments (VLEs) negotiate the agency of educators and how they shape their teaching practice. Since the same kinds of VLE tools have been widely implemented throughout Norwegian education, it is interesting to study how practices are formed in different parts of the educational system. This research is therefore designed as a case study of two different teaching contexts representing lecturers from a higher education institution and teachers from primary schools. Data are collected by means of interviews, online logging of VLE activities and self-reported personal logs. From the analysis of the data, three main networks of aligned interests can be identified. In each of those, the sociomaterial agency of the teaching practice with VLE is crucial in shaping and consolidating the network.