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排序方式: 共有205条查询结果,搜索用时 15 毫秒
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Electrospray Encapsulation of Hydrophilic and Hydrophobic Drugs in Poly(L‐lactic acid) Nanoparticles
Hanna Valo Leena Peltonen Satu Vehviläinen Milja Karjalainen Risto Kostiainen Timo Laaksonen Jouni Hirvonen 《Small (Weinheim an der Bergstrasse, Germany)》2009,5(15):1791-1798
An electrospray method is developed for preparation of beclomethasone‐dipropionate‐ and salbutamol‐sulfate‐loaded biodegradable poly(L ‐lactic acid) nanoparticles. Different set‐up parameters for electrospraying are examined on particle size, and preparation conditions are optimized for producing spherical‐drug‐loaded nanoscale particles by controllable processing parameters. Polylactide (PLA)–drug nanoparticles with average diameters of around 200 nm are achieved in a stable cone‐jet mode with a flow rate of 4 µL min?1, polymer concentration of 1%, and ammonium hydroxide content of 0.05%. Morphology and size of the drug–polymer nanoparticles are analyzed by scanning electron microscopy and transmission electron microscopy. Changes in the crystallinity of the PLA polymer and the model drugs are detected by X‐ray powder diffraction, and the absence of molecular interactions are confirmed by thermal analyses. The results indicate clearly that electrospraying is a potential method for producing polymeric nanoparticles and for encapsulating both hydrophilic and hydrophobic drugs efficiently into the nanoparticles. 相似文献
123.
Leena Nebhani Christopher Barner‐Kowollik 《Advanced materials (Deerfield Beach, Fla.)》2009,21(34):3442-3468
The performance of solid substrates is not only governed by their molecular constitution, but is also critically influenced by their surface constitution at the solid/gas or solid/liquid interface. In here, we critically review the use of orthogonal chemical transformations (so‐called click chemistry) to achieve efficient surface modifications of materials ranging from gold and silica nanoparticles, polymeric films, and microspheres to fullerenes as well as carbon nanotubes. In addition, the functionalization of surfaces via click chemistry with biomolecules is explored. Although a large host of reactions fulfilling the click‐criteria exist, pericyclic reactions are most frequently employed for efficient surface modifications. The advent of the click chemistry concept has led—as evident from the current literature—to a paradigm shift in current approaches for materials modification: Away from unspecific and nonselective reactions to highly specific true surface engineering. 相似文献
124.
Endotoxins associated with cyanobacteria and their removal during drinking water treatment 总被引:7,自引:0,他引:7
The aim of this study was to investigate endotoxin concentrations in cyanobacterial water blooms and strains, and to assess the removal of endotoxins during drinking water treatment. Endotoxin concentrations were measured from 151 hepatotoxic, neurotoxic and non-toxic cyanobacterial water blooms by using Limulus amebocyte lysate (LAL) assay, and the results were compared to bacterial data. Endotoxin activities ranged from 20 to 3.8 x 10(4) endotoxin units (EU) per ml. Endotoxicity of the samples correlated with phycobiliprotein concentration that was used to assess cyanobacterial abundance, heterotrophic plate count, and Aeromonas spp. but it did not correlate with the number of coliforms or streptococci. The high endotoxin concentrations occasionally detected in the water bloom samples were probably due to Gram negative bacteria that existed together with cyanobacteria since the 26 axenic cyanobacterial strains from different genera that were studied showed very low endotoxin activity. No differences in endotoxin activity were detected between hepatotoxic, neurotoxic and non-toxic strains. Removal of endotoxins during drinking water treatment was studied at nine waterworks that previously had been associated with high numbers of cyanobacteria and that used different processes for water purification. Endotoxin concentration in raw waters ranged from 18 to 356 EU ml(-1). The treatment processes reduced 59-97% of the endotoxin activity; in the treated water the concentration ranged from 3 to 15 EU ml(-1). The most significant reduction occurred at the early stages of water treatment, during coagulation, settling and sand filtration. Activated carbon filtration either increased or had no effect on endotoxin concentration. Ozonation and chlorination had little effect on the endotoxin concentrations. 相似文献
125.
Mervi T. Hyvnen Olga A. Smirnova Vladimir A. Mitkevich Vera L. Tunitskaya Maxim Khomutov Dmitry S. Karpov Sergey P. Korolev Merja R. Hkkinen Marko Pietil Marina B. Gottikh Jouko Vepslinen Leena Alhonen Alexander A. Makarov Sergey N. Kochetkov Heather M. Wallace Tuomo A. Keinnen Alex R. Khomutov 《International journal of molecular sciences》2022,23(9)
The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhibits polyamine uptake and targets ornithine decarboxylase (ODC), the rate-limiting enzyme of polyamine biosynthesis, for proteasomal degradation. Here we report, for the first time, that polyamines induce dimerization of mouse recombinant full-length OAZ1, forming an (OAZ1)2-Polyamine complex. Dimerization could be modulated by functionally active C-methylated spermidine mimetics (MeSpds) by changing the position of the methyl group along the Spd backbone—2-MeSpd was a poor inducer as opposed to 1-MeSpd, 3-MeSpd, and Spd, which were good inducers. Importantly, the ability of compounds to inhibit polyamine uptake correlated with the efficiency of the (OAZ1)2-Polyamine complex formation. Thus, the (OAZ1)2-Polyamine complex may be needed to inhibit polyamine uptake. The efficiency of polyamine-induced ribosomal +1 frameshifting of OAZ1 mRNA could also be differentially modulated by MeSpds—2-MeSpd was a poor inducer of OAZ1 biosynthesis and hence a poor downregulator of ODC activity unlike the other MeSpds. These findings offer new insight into the OAZ1-mediated regulation of polyamine homeostasis and provide the chemical tools to study it. 相似文献
126.
127.
Katja Eubler Pia Rantakari Heidi Gerke Carola Herrmann Annika Missel Nina Schmid Lena Walenta Shibojyoti Lahiri Axel Imhof Leena Strauss Matti Poutanen Artur Mayerhofer 《International journal of molecular sciences》2021,22(9)
The cation channel TRPV2 is known to be expressed by murine macrophages and is crucially involved in their functionality. Macrophages are frequent cells of the mouse testis, an immune-privileged and steroid-producing organ. TRPV2 expression by testicular macrophages and possible changes associated with age or inflammation have not been investigated yet. Therefore, we studied testes of young adult and old wild-type (WT) and AROM+ mice, i.e., transgenic mice overexpressing aromatase. In these animals, inflammatory changes are described in the testis, involving active macrophages, which increase with age. This is associated with impaired spermatogenesis and therefore AROM+ mice are a model for male infertility associated with sterile inflammation. In WT animals, testicular TRPV2 expression was mapped to interstitial CD206+ and peritubular MHC II+ macrophages, with higher levels in CD206+ cells. Expression levels of TRPV2 and most macrophage markers did not increase significantly in old mice, with the exception of CD206. As the number of TRPV2+ testicular macrophages was relatively small, their possible involvement in testicular functions and in aging in WT mice remains to be further studied. In AROM+ testis, TRPV2 was readily detected and levels increased significantly with age, together with macrophage markers and TNF-α. TRPV2 co-localized with F4/80 in macrophages and further studies showed that TRPV2 is mainly expressed by unusual CD206+MHC II+ macrophages, arising in the testis of these animals. Rescue experiments (aromatase inhibitor treatment and crossing with ERαKO mice) restored the testicular phenotype and also abolished the elevated expression of TRPV2, macrophage and inflammation markers. This suggests that TRPV2+ macrophages of the testis are part of an inflammatory cascade initiated by an altered sex hormone balance in AROM+ mice. The changes in testis are distinct from the described alterations in other organs of AROM+, such as prostate and spleen. When we monitored TRPV2 levels in another immune-privileged organ, namely the brain, we found that levels of TRPV2 were not elevated in AROM+ and remained stable during aging. In the adrenal, which similar to the testis produces steroids, we found slight, albeit not significant increases in TRPV2 in both AROM+ and WT mice, which were associated with age. Thus, the changes in the testis are specific for this organ. 相似文献
128.
ABSTRACTDetection and localisation of contacts using sensor array play a significant role in the area of array signal processing. In this paper, a new beam-forming analysis for broad-banded quadratic frequency modulated (QFM) signals using generalised time–frequency transform (GTFT) is presented by extending the conventional fractional Fourier transform (FrFT). As FrFT is constrained to the analysis of linear chirps, detection using GTFT is found to be the appropriate selection for higher-order chirps with the suitable choice of the kernel. The parameters of the QFM signal is extracted using the polynomial chirplet transform time–frequency distribution method. Subsequently, the direction of arrival (DoA) estimation algorithms viz. conventional beam-former (CBF), minimum variance distortionless response (MVDR), multiple signal classification (MUSIC) and minimum norm (MN) are re-cast using the quadratic steering vector derived for QFM chirps and hence renamed as GTFT-CBF, GTFT-MVDR, GTFT-MUSIC and GTFT-MN, respectively. The efficacy of the algorithm is validated through various signals including practical sonar array data. It is seen from the theoretical analysis as well as simulations that GTFT-MUSIC excels other DoA (bearing) estimation techniques. The GTFT analysis on back propagated signals using sonar array aided in effective underwater channel modelling. 相似文献
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130.
Leena Kapoor 《国际可持续能源杂志》2019,38(7):692-700
This work aims to utilise the experimental approach to perform the analysis of three-biomass feed stocks – bamboo, mustard and camellia and to provide insight into the operation and design of pyrolysis processes. Experiments on biomass fast pyrolysis were performed in a fixed bed (tubular) reactor at a temperature of 500°C and a residence time of 2?min under the constant flow of nitrogen. The analysis of pyrolysis gases and bio oil produced by pyrolysis was done using GC-MS and GC-TCD. Hydrous pyrolysis of biomasses was performed in a high-pressure autoclave for the temperature range 250–400°C and at a pressure of 20?bar with 30?min of residence time. Experiments were conducted both with and without the use of a catalyst. The pyrolysis vapour is made to pass through the catalyst bed of ZSM-5 (Si/Al?=?35). The results for all the biomass samples are then compared. 相似文献