Keratin 17 gene expression during the murine hair cycle

Treatment of rats with phenytoin (DPH), an anti-epileptic drug, results in lower tissue thyroid hormone (TH) levels and interferes with the metabolic pathway of TH. To test the hypothesis that DPH affects the enterohepatic cycle of TH and, thus, the kinetics of TH turnover, we performed a kinetic experiment (three-compartment analysis) and a steady-state, double-isotope equilibrium experiment in rats treated for 3 weeks with DPH (50 mg/kg body weight per day) and in untreated controls. This included measurements of TH and TH metabolite levels, as well as the activities of enzymes involved in the TH metabolic pathway. DPH treatment resulted in a decrease in the production of thyroxine (T4) (by 25%) and tri-iodothyronine (T3) (by 37%), a decrease in the T3 concentration in all three pools, and a redistribution of T4 from the fast to the slow pool. The amount of T4 increased in intestinal contents and feces by 66% and 71% respectively. Expressed as a fraction of daily TH disposal, fecal loss of T4 was enhanced from 10 to 23% and that of T3 from 16 to 21%. An increase in T4 and T3 UDP-glucuronyltransferase activities was observed, suggesting that the increased fecal loss of T4 and T3 is secondary to an increased biliary output of their glucuronides. The reduced secretion of TH and increased fecal clearance during DPH treatment can lead in the long run to depletion of TH stores.     

A Dual-Fed, Self-Diplexing PIFA and RF Front-End

A dual-fed, self-diplexing planar inverted F antenna and an associated RF front-end are described. It is shown that co-design of the antenna and front-end can be used to double the operational bandwidth, without significant size or performance penalties. Indeed, the use of two feeds allows the antenna to be self-diplexing, which results in improved overall efficiency     

Measurements and analysis of transmitted spectra from LOTUS fission-suppressed hybrid blanket driven by D-T neutrons

The neutron spectra transmitted across a fission-suppressed hybrid blanket and its components, driven by a low intensity 14 MeV Haefely neutron generator, were measured with a 2×2 NE213 detector at LOTUS facility. These experiments have been analyzed with 2D and 3D codes DOT3.5 and MCNP, respectively. The spectral integrals between 15 to 1 MeV show good agreement among the 2D, the 3D, and the NE213 for 15 cm lead, 18 cm beryllium, and 25 cm graphite slabs. However, there are large discrepancies for 6.2 cm stainless steel and 15 cm lithium carbonate slabs. The assemblies involving two or more of these slabs reflect these tendencies. We observe also considerable disagreement over pointwise spectra for a number of assemblies.Work done while on visiting assignment to Institut de Génie Atomique, E.P.F.L.     

MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand

This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid LC-ESI-MS/MS method. Binding of Org25543 at GlyT2 was characterized in kinetic and saturation experiments with an off-rate of 7.07×10⁻³ s⁻¹, an on-rate of 1.01×10⁶ M⁻¹ s⁻¹, and an equilibrium dissociation constant of 7.45 nM. Furthermore, the inhibitory constants of 19 GlyT ligands were determined in competition experiments. The validity of the GlyT2 affinities determined with the binding assay was examined by a comparison with published inhibitory potencies from various functional assays. With the capability for affinity determination towards GlyT2 the developed MS Binding Assays provide the first tool for affinity profiling of potential ligands and it represents a valuable new alternative to functional assays addressing GlyT2.     

Design of Dual-Gate P-type IMOS Based Industrial Purpose Pressure Sensor

Silicon - In this treatise, we have proposed a Single Material Gate–Dual Gate Impact Ionization Metal Oxide Semiconductor (SMG DG-IMOS) based Pressure Sensor. The pressure sensor has the most...     

Influence of heat treatment on tribological behaviors of novel wrought aluminum bronze

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Modelling a circulating fluidized bed riser reactor with gas—solids downflow at the wall

A predictive model was developed for the fully developed zone of a circulating fluidized bed (CFB) riser reactor operating in the fast fluidization regime that overcomes limitations of existing models. The model accounts for the upward flow of gas and solids in the core and downward flow of the two phases in the annulus. Additionally, a numerical solution methodology for the simulation of a riser reactor employing the hydrodynamic model was devised. A simulation was performed using the fast, main Claus reaction to demonstrate the effects of backmixing in the fast fluidization regime. It was found that the molar flow rates of the reactants leaving a fast fluidized CFB riser reactor were significantly higher than those leaving an identical reactor operating in the pneumatic transport regime.     

Study of the composition effect of glass ceramic and silver on poly(vinyl butyral) thermal degradation with thermogravimetric analysis

The thermal degradation of poly(vinyl butyral) (PVB)/glass ceramic, PVB/Ag, and PVB/glass ceramic/Ag composites was investigated with thermogravimetric analysis in nitrogen and air. Thermogravimetric data revealed that the compositions of both inorganic materials in air could greatly influence the thermal degradation of PVB. The degradation reactions of PVB/ceramic and PVB/Ag composites began earlier and accelerated rapidly at lower temperatures. The overall degradation period was obviously shortened for the thermal degradation of PVB/Ag in air, whereas a longer time was required for the PVB/ceramic composite than for PVB. Moreover, dual effects of ceramic and Ag on the thermal degradation of PVB were observed for PVB/ceramic/Ag composites. In addition, the catalytic effects of ceramic and Ag on the degradation reaction of PVB in air were verified with a kinetic analysis. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2142–2149, 2004