LSS: an S-Plus/R program for the accelerated failure time model to right censored data based on least-squares principle

Due to lack of proper inference procedure and software, the ordinary linear regression model is seldom used in practice for the analysis of right censored data. This paper presents an S-Plus/R program that implements a recently developed inference procedure [Z. Jin, D.Y. Lin, Z. Ying, On least-squares regression with censored data, Biometrika 93 (2006) 147-161] for the accelerated failure time model based on the least-squares principle. The program is user-friendly and yields outputs similar to S-Plus/R function 1m.     

A Compact Fourth-Order Finite Difference Scheme for Unsteady Viscous Incompressible Flows

In this paper, we extend a previous work on a compact scheme for the steady Navier–Stokes equations [Li, Tang, and Fornberg (1995), Int. J. Numer. Methods Fluids, 20, 1137–1151] to the unsteady case. By exploiting the coupling relation between the streamfunction and vorticity equations, the Navier–Stokes equations are discretized in space within a 3×3 stencil such that a fourth order accuracy is achieved. The time derivatives are discretized in such a way as to maintain the compactness of the stencil. We explore several known time-stepping approaches including second-order BDF method, fourth-order BDF method and the Crank–Nicolson method. Numerical solutions are obtained for the driven cavity problem and are compared with solutions available in the literature. For large values of the Reynolds number, it is found that high-order time discretizations outperform the low-order ones.     

一种通用的数据类型——十进制浮点数

为智能仪表提供一种“十进制浮点数”,其特点是值域宽、值准确,它能代替整、长整型、三字节浮点数、四字节浮点数、BCD码数。用它通信可简化和统一仪表的通信协议,为制定仪表通用通信协议标准创造条件。     

提取抽油井液位回音信号中液位值的方法

分析了抽油井液位回音曲线的特性,给出了检测曲线中特性脉冲的电路原理,介绍了根据统计规律计算声速和液位值的方法,该方法与计算机结合可以消除在测量中人为读数和干扰的影响,使得测量变得精确、方便、直接。此方法在实际中已得到了较好的应用。     

我国城市排水体系中重点推广基于Web及“Infranet＋Indtranet＋Internet”一体化技术的SCADA控制系统

从城市排水行业背景的角度介绍了基于Web及“Infranet Intranet Internet”一体化模式,这是当前工业自动化系统的发展方向,对城市排水事业建设具有巨大的促进作用。     

Studying the protein-protein interactions in the postsynaptic density by means of immunoabsorption and chemical crosslinking

Postsynaptic densities (PSDs), isolated from porcine cerebral cortices, are large disk-shaped aggregates consisting of hundreds of different proteins. To study the protein-protein interactions in such complex supramolecules, we developed a procedure to break up the PSD's overall structure, while preserving some interactions between individual proteins. Using the resulting PSD sample and an indirect immunoabsorption procedure, PSD-95 was isolated along with the α- and β-subunits of calcium calmodulin-dependent protein kinase II (CaMKIIα and CaMKIIβ), α-tubulin, β-tubulin, and Chapsyn110. Similarly, CaMKIIα was isolated along with CaMKIIβ, α-tubulin, β-tubulin, and small amounts of PSD-95. The proteins isolated from PSDs treated with a cleavable bifunctional crosslinking reagent were further subjected to diagonal gel electrophoresis analysis, and the results indicated that CaMKIIα resides next to α-tubulin in the PSD. Overall, the results obtained here suggest that within the PSD, large aggregates of CaMKIIα, CaMKIIβ, α-tubulin, and β-tubulin may occur that indirectly associate with PSD-95 and Chapsyn110. Such a protein organization would allow interactions with F-actin in the cytoplasm and with proteins, such as N-methyl-D-aspartate receptors, which reside on the postsynaptic membrane. Furthermore, it would facilitate binding to proteins such as the various microtubule-associated proteins that reside in the core region of the PSD.     

Neuroproteomics and its applications in research on nicotine and other drugs of abuse

The rapidly growing field of neuroproteomics is able to track changes in protein expression and protein modifications underlying various physiological conditions, including the neural diseases related to drug addiction. Thus, it presents great promise in characterizing protein function, biochemical pathways, and networks to understand the mechanisms underlying drug dependence. In this article, we first provide an overview of proteomics technologies and bioinformatics tools available to analyze proteomics data. Then we summarize the recent applications of proteomics to profile the protein expression pattern in animal or human brain tissues after the administration of nicotine, alcohol, amphetamine, butorphanol, cocaine, and morphine. By comparing the protein expression profiles in response to chronic nicotine exposure with those appearing in response to treatment with other drugs of abuse, we identified three biological processes that appears to be regulated by multiple drugs of abuse: energy metabolism, oxidative stress response, and protein degradation and modification. Such similarity indicates that despite the obvious differences among their chemical properties and the receptors with which they interact, different substances of abuse may cause some similar changes in cellular activities and biological processes in neurons.     

Performance evaluation of a dental handpiece in simulation of clinical finishing using a novel 2DOF in vitro apparatus

This paper reports on the performance evaluation of a dental handpiece in simulation of clinical finishing using a novel two-degrees-of-freedom (2DOF) in vitro apparatus. The instrumented apparatus consisted of a two-dimensional computer-controlled coordinate worktable carrying a dental handpiece, a piezoelectric force dynamometer, and a high-speed data acquisition and signal conditioning system for simulating the clinical operations and monitoring the dental finishing processes. The performance of the dental handpiece was experimentally evaluated with respect to rotational speed, torque, and specific finishing energy under the applied clinical finishing conditions. The results show that the rotational speeds of the dental handpiece decreased by increasing either the depth of cut or the feed rate at a constant clinically applied air pressure and water flowrate. They also decreased when increasing both the tangential and normal finishing forces. The specific finishing energy decreased with an increase in either depth of cut or feed rate, while the finishing torque increased as either the depth of cut or the feed rate was increased. Implications of these results were to provide guidance for proper applications of dental handpieces in clinical practice.