Nanoscale Calculation of Proton-Induced DNA Damage Using a Chromatin Geometry Model with Geant4-DNA

Monte Carlo simulations can quantify various types of DNA damage to evaluate the biological effects of ionizing radiation at the nanometer scale. This work presents a study simulating the DNA target response after proton irradiation. A chromatin fiber model and new physics constructors with the ELastic Scattering of Electrons and Positrons by neutral Atoms (ELSEPA) model were used to describe the DNA geometry and the physical stage of water radiolysis with the Geant4-DNA toolkit, respectively. Three key parameters (the energy threshold model for strand breaks, the physics model and the maximum distance to distinguish DSB clusters) of scoring DNA damage were studied to investigate the impact on the uncertainties of DNA damage. On the basis of comparison of our results with experimental data and published findings, we were able to accurately predict the yield of various types of DNA damage. Our results indicated that the difference in physics constructor can cause up to 56.4% in the DNA double-strand break (DSB) yields. The DSB yields were quite sensitive to the energy threshold for strand breaks (SB) and the maximum distance to classify the DSB clusters, which were even more than 100 times and four times than the default configurations, respectively.     

实测卫星频谱占用状态拟合与预测方法

由于在不同时间、不同空间卫星接收数据底噪是动态起伏的,传统建模固定门限的方法存在缺陷。本文在时间维度上对卫星频谱感知数据的频谱占用模型进行分析,利用自适应阈值法确定噪声门限,对卫星频谱数据进行预处理,得到卫星频谱占用长度序列。为对卫星频谱的态势进行有效的统计分析,利用泊松分布和指数分布方法对频谱占用时间长度序列的概率密度曲线进行拟合,得到了适用于卫星频谱占用时间序列的概率分布模型。基于所得的卫星频谱占用状态模型,通过两状态马尔可夫链计算出卫星信道某一频点的状态转移矩阵,从而预测出信道占用和空闲的概率。利用卫星频谱感知数据构建的数据集进行反向传播(BP)神经网络训练,预测某一频点的占用长度。通过计算BP神经网络与传统的长短期记忆(LSTM)神经网络预测法的均方根误差(RMSE),得到LSTM神经网络的RMSE为2.208 1,BP神经网络的RMSE为0.172 8。评估结果表明,BP神经网络准确度高。     

电动机固态节能起动器在皮带输送机上的应用

文中介绍了固态节能起动器的工作原理,并在某港务公司的3台皮带运输机上分别对它们进行了安装固态节能起动器前后功耗的对比现场测试,结果显示,安装节能起动器后,可降低起动电流、减少有功损耗和无功损耗,提高了功率因数。     

动态事件触发机制下二阶多智能体系统完全分布式控制

本文研究了无向通信拓扑下二阶多智能体系统的一致性问题, 分别针对有领导者和无领导者的情形, 设计 了一类基于辅助动态变量的完全分布式事件触发控制策略, 该策略具有参数较少且易调等特点. 智能体自身的触 发函数满足条件时才向邻居广播自身的状态信息, 有效避免了连续通信, 减少了系统能量耗散. 每个智能体的控制 协议和触发函数都只用到自身的状态和邻居触发时刻的状态, 不涉及邻居的实时状态信息, 也不依赖通信拓扑网络 的任何全局信息. 利用代数图论以及Lyapunov稳定性理论, 证明在所提出的控制策略下, 二阶多智能体系统能够实 现渐近一致性, 且不存在Zeno行为. 仿真示例进一步验证了理论结果的有效性.     

Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics

Stanene(Sn)-based materials have been extensively applied in industrial production and daily life,but their potential biomedi-cal application remains largely un...     

一种新型的适应于MANET的基于移动代理的对等入侵检测系统

移动自组织网络(Mobile Ad hoc Networks,MANET)是一种开放性的媒介系统,从而很容易受到黑客的入侵.提出了一种有效的适应于MANET的入侵检测系统,叫做MAPIDS(Mobile Agent-based Peer-to-peer Intrusion Detection System).该系统一旦发现网络中的可疑行为,就会引发一次集体投票过程,以确定该可疑行为是否是入侵行为,并根据投票结果作出相应的进一步处理.相比于其他同样基于集体决策机制的入侵检测系统,MAPIDS节省了更多的网络带宽和电池能耗,并且该系统不存在稀疏节点问题.     

Occurrence and characteristics of Vibrio vulnificus in retail marine shrimp in China

Vibrio vulnificus is a gram-negative bacterium that naturally occurs in estuarine waters and marine environment. Consumption of seafood contaminated with V. vulnificus or exposure to the contaminated water causes septicemia, gastroenteritis or wound infections in humans. This study aimed at identifying the prevalence of V. vulnificus in shrimps in Chinese seafood market. From June to September 2009, 239 samples encompassing six shrimp species were collected from ten cities in China. To quantify the prevalence and the levels of V. vulnificus in shrimps, the most probable number (MPN) method was used combining with the polymerase chain reaction (PCR) which was used to classify the isolates by detecting V. vulnificus hemolysin gene (vvhA). One hundred and forty out of 239 samples were positive for V. vulnificus, with the geometric mean level at 153.3 MPN/g. The prevalence and levels of V. vulnificus in shrimps varied in different geographic areas, with the values for the samples in the South cities (179.6 MPN/g) remarkably higher than that in the North cities (7.6 MPN/g). In addition, we found that 61.7% (79/128) of the V. vulnificus positive samples contained C-type (Clinical) strains and 8 contained E-type (Environmental) strains. The antimicrobial susceptibility of the isolates to 12 antibiotics was tested as well. Most of the 169 isolates remained susceptible to the majority of antimicrobials tested, whereas some strains tend to be less sensitive to amikacin, ampicillin, tetracycline and gentamicin. In conclusion, V. vulnificus is commonly found in retail marine shrimp in Chinese seafood market, and most of the shrimp samples contained C-type strains, which may pose a potential threat to human health.     

PUR热熔胶和装订涂布系统

<正>PUR热熔胶(Poly Urethan Reactive Hotmelt Adhesive,聚氨酯反应型热熔胶)已经历了从第一代到第二、第三代的改进,现在正向UV热熔胶发展。为什么在书籍上要改用PUR热熔胶,它与EVA(乙烯-醋酸乙烯)热熔胶性能有何差异?如果对PUR热熔胶缺少正确的认识,装订出的书籍的质量与生产效率就会大打折扣。适用PUR热熔胶的涂布设备有     

Fretting wear behavior of bulk amorphous steel

Fretting wear of Fe₄₁Co₇Cr₁₅Mo₁₄C₁₅B₆Y₂ bulk metallic glass (BMG) was investigated using the ball-on-disc measurement. The wear behaviors of the samples roughly follow the classical Archard wear law at room temperature. The influence of temperature on wear resistance (R_w) and microhardness (H_v) was evaluated. A good linear correlation was found between R_w and H for the Fe-based BMG. The results indicate that the hardness softening is responsible for the decrease of R_w at high temperature. The wear mechanism at high temperature was elucidated through the analysis of oxidation and debris morphology on the wear scar. Compared with traditional crystalline steels and other non-ferrous metal-based glassy alloys, the bulk amorphous steel shows higher wear resistance and hardness, which promotes its application as an advanced engineering material.