Economic Value of Combined Best Practice Use

This paper measures the value of best practices based on data taken from the Construction Industry Institute Benchmarking and Metrics database. A three-step process provides the basis for measuring the potential benefits of increased best practice use. First, a practice use index is derived to model the way in which best practices are utilized on actual projects. The index combines data from eight best practices to create a single measure of practice utilization. Second, a project performance index, combining cost and schedule metrics, is derived as an indicator of overall project performance. Third, the practice use index is correlated with cost, schedule, and overall project performance metrics. Both owners and contractors benefit from increased practice use. Potential cost savings for owners range from $1.7 to $3.4 million, depending on industry group and project size. Potential cost savings for contractors are higher, averaging $7.2 million for the typical $88 million heavy industrial project. Benefits from schedule reductions are most apparent for owners. On large building projects, schedule reductions for owners average 27 weeks. Finally, improvements in overall project performance on the order of 30% are observed for both owners and contractors.     

A Fair Assessment of Evaluation Tools for the Murine Microbead Occlusion Model of Glaucoma

Despite being one of the most studied eye diseases, clinical translation of glaucoma research is hampered, at least in part, by the lack of validated preclinical models and readouts. The most popular experimental glaucoma model is the murine microbead occlusion model, yet the observed mild phenotype, mixed success rate, and weak reproducibility urge for an expansion of available readout tools. For this purpose, we evaluated various measures that reflect early onset glaucomatous changes in the murine microbead occlusion model. Anterior chamber depth measurements and scotopic threshold response recordings were identified as an outstanding set of tools to assess the model’s success rate and to chart glaucomatous damage (or neuroprotection in future studies), respectively. Both are easy-to-measure, in vivo tools with a fast acquisition time and high translatability to the clinic and can be used, whenever judged beneficial, in combination with the more conventional measures in present-day glaucoma research (i.e., intraocular pressure measurements and post-mortem histological analyses). Furthermore, we highlighted the use of dendritic arbor analysis as an alternative histological readout for retinal ganglion cell density counts.     

Impact of parboiling conditions on Maillard precursors and indicators in long-grain rice cultivars

The effect of steaming conditions (mild, intermediate and severe) during parboiling of five different long-grain rice cultivars (brown rice cultivars Puntal, Cocodrie, XL8 and Jacinto, and a red rice) on rice colour, and Maillard precursors and indicators was investigated. Rice colour increased with severity of parboiling conditions. Redness increased more than yellowness when parboiling brown rice. Parboiling turned red rice black. It changed the levels of glucose, fructose, sucrose, and maltose. Losses of the non-reducing sugar, sucrose were caused by both leaching into the soaking water and enzymic conversion, rather than by thermal degradation during steaming. Concentrations of the reducing sugars, glucose and fructose, in intermediately parboiled rice were higher than those of mildly parboiled rice. After severe parboiling, glucose levels were lower than those of intermediately parboiled rice, while fructose levels were higher. These changes were ascribed to the sum of losses in the Maillard reaction (MR), formations as a result of starch degradation and isomerisation of glucose into fructose. It was clear that the ε-amino group of protein-bound lysine was more affected by parboiling conditions and loss in MRs, than that of free lysine. Low values of the MR indicators furosine and free 5-hydroxymethyl-2-furaldehyde (HMF) in processed brown and red rices were related to mild parboiling, whereas high furosine and low free HMF levels were indicative of rices being subjected to intermediate processing conditions. High furosine and high free HMF contents corresponded to severe hydrothermal treatments. The strong correlation (r = 0.89) between the free HMF levels and the increase in redness of parboiled brown rices suggested that Maillard browning was reflected more in the red than in the yellow colour.     

Auditory babble and cognitive efficiency: Role of number of voices and their location.

Four experiments investigated the disruptive effect on short-term memory of irrelevant babble speech. With monaural presentation, 1 voice and 2 voices produced roughly the same degree of disruption, but babble of 6 voices reduced errors significantly. The same pattern was shown when the speech was in a language that the participants did not understand. As the number of voices in the babble was increased from 1 to 6, the function relating the number of voices to errors was monotonic only over part of the range. Allocating each voice to a different spatial location restored its disruptive capacity, compared with a condition where 6 voices came from the 1 location. In practice, the disruptive effect of irrelevant speech will be less where the number of voices is greater (such as in large office spaces), but acoustic conditions that help localization of individual voices will increase disruption. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Phonological similarity in the irrelevant speech effect: Within- or between-stream similarity?

Irrelevant background speech disrupts serial recall of visually presented lists of verbal material. In 4 experiments, the hypothesis that this disruption is due to the phonological similarity of the irrelevant sound and the list to be recalled was tested. In Experiment 1, item length was controlled and a large irrelevant speech effect was found, but the effect of phonological similarity was small and confined to recency. In Experiment 2, words in the irrelevant stream were used, and the experiment showed an irrelevant speech effect in which phonological similarity played a small part. Experiments 3 and 4 found that similarity (rhyming) within the irrelevant sound stream decreased the level of disruption, and the effect was more marked when the visually presented lists contained items that did not rhyme with one another. Rather than supporting a phonological similarity hypothesis, the results support a changing state hypothesis. (PsycINFO Database Record (c) 2010 APA, all rights reserved)