电力企业信息统计系统逻辑构架研究与实现

软件构架在对可靠性、可移植性、安全性等性能要求比较高的软件开发过程中起着重要的作用.构架的好坏直接关系到系统的成功与否.根据实际需求,在设计中采用了模块视图分层风格,把系统的责任分解成小模块,使变更被隔离在一个模块内,大大提高了软件复用率,符合企业信息化的发展要求.     

一种电感式接近开关的失效分析方法

电感式接近开关的封装形式中,全金属封装是比较常见的一种类型.目前,市场上的电感式接近开关,包括具有内腔的外壳和设置在内腔中的开关组件,其开关组件多采用环氧树脂固定在内腔中.在这类接近开关的失效分析工作中,由于难以去除金属外壳及内部灌封树脂,常使失效分析工作难以开展.论文结合一款全金属封装的电感式接近开关的失效案例,在不...     

新型多孔镁压缩性能的有限元分析

利用有限元方法建立了激光打孔制备的直孔型多孔镁样品的压缩模型,系统分析了孔隙率、孔径及孔的排布对多孔镁样品压缩性能的影响,初步探讨了多孔镁在压缩过程中的变形规律.模拟计算结果表明,随着孔隙率、孔径的增加和孔的排布角的减小,多孔镁压缩曲线下移,屈服强度和弹性模量随之下降;多孔镁的压缩变形规律符合金属的最小阻力定律.     

富氧炭浸提金工艺在哈德门金矿的应用

介绍了富氧炭浸提金工艺在哈德门金矿二期扩建工程中的应用。在不增加浸出设备的前提下,生产能力由一期的３００ｔ／ｄ提高到６００ｔ／ｄ,浸出时间由３０ｈ缩短为１５ｈ,氰化物消耗下降,而富氧前后浸出率相当;节省了基建投资,降低了生产成本。     

基于空-频域映射与虚警抑制的弱小目标检测算法

为了有效控制红外弱小目标检测过程中的虚警率,提高复杂云背景下的目标检测准确度,提出了基于空域-频域映射与虚警抑制的弱小目标检测算法。根据红外中心像素不同方向上的强度值,构建了方向最大中值滤波器,有效消除噪声;并利用中心像素与其邻域像素的强度差异,形成背景抑制滤波,充分增强弱小目标;考虑云区域的特有属性,联合非线性滤波,定义了云区域识别机制,提取空域映射;引入Butterworth差异低通滤波器,对去噪图像中的显著目标完成初步识别;基于其幅度信息,进行显著目标的精细检测;再利用细显著性检测结果,计算阈值,利用二值分割方法来获取去噪红外图像的频域映射;联合空域映射与频域映射,提取红外图像中的候选目标;根据真实动目标与虚警之间的运动特征差异,利用多尺度改进的管道滤波来抑制虚警,准确识别出真实目标。实验数据表明,相对于已有的弱小目标识别方案,所提方案能够准确地识别出真实目标,拥有更好的ROC特性曲线。     

Cytogenetic and Molecular Marker Analyses of a Novel Wheat–Psathyrostachys huashanica 7Ns Disomic Addition Line with Powdery Mildew Resistance

Powdery mildew caused by Blumeria graminis f. sp. tritici is a devastating disease that reduces wheat yield and quality worldwide. The exploration and utilization of new resistance genes from wild wheat relatives is the most effective strategy against this disease. Psathyrostachys huashanica Keng f. ex P. C. Kuo (2n = 2x = 14, NsNs) is an important tertiary gene donor with multiple valuable traits for wheat genetic improvement, especially disease resistance. In this study, we developed and identified a new wheat—P. huashanica disomic addition line, 18-1-5—derived from a cross between P. huashanica and common wheat lines Chinese Spring and CSph2b. Sequential genomic and multicolor fluorescence in situ hybridization analyses revealed that 18-1-5 harbored 21 pairs of wheat chromosomes plus a pair of alien Ns chromosomes. Non-denaturing fluorescence in situ hybridization and molecular marker analyses further demonstrated that the alien chromosomes were derived from chromosome 7Ns of P. huashanica. The assessment of powdery mildew response revealed that line 18-1-5 was highly resistant at the adult stage to powdery mildew pathogens prevalent in China. The evaluation of agronomic traits indicated that 18-1-5 had a significantly reduced plant height and an increased kernel length compared with its wheat parents. Using genotyping-by-sequencing technology, we developed 118 PCR-based markers specifically for chromosome 7Ns of P. huashanica and found that 26 of these markers could be used to distinguish the genomes of P. huashanica and other wheat-related species. Line 18-1-5 can therefore serve as a promising bridging parent for wheat disease resistance breeding. These markers should be conducive for the rapid, precise detection of P. huashanica chromosomes and chromosomal segments carrying Pm resistance gene(s) during marker-assisted breeding and for the investigation of genetic differences and phylogenetic relationships among diverse Ns genomes and other closely related ones.     

柔性夹具技术研究

为适应快速多变的市场需求,制造企业需要设计并应用柔性夹具。介绍了柔性夹具的发展及特点,给出了柔性夹具的设计依据,并从零件结构及工艺、组成元件确定、强度与精度保证等方面分析了柔性夹具的设计方法。     

Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and have therefore become a focus in the development of cell-based immunotherapy. iNKT cells attack tumor cells using multiple mechanisms with a high efficacy; however, their clinical application has been limited because of their low numbers in cancer patients and difficulties in infiltrating solid tumors. In this study, we aimed to overcome these critical limitations by using α-GalCer, a synthetic glycolipid ligand specifically activating iNKT cells, to recruit iNKT to solid tumors. By adoptively transferring human iNKT cells into tumor-bearing humanized NSG mice and administering a single dose of tumor-localized α-GalCer, we demonstrated the rapid recruitment of human iNKT cells into solid tumors in as little as one day and a significantly enhanced tumor killing ability. Using firefly luciferase-labeled iNKT cells, we monitored the tissue biodistribution and pharmacokinetics/pharmacodynamics (PK/PD) of human iNKT cells in tumor-bearing NSG mice. Collectively, these preclinical studies demonstrate the promise of an αGC-driven iNKT cell-based immunotherapy to target solid tumors with higher efficacy and precision.     

喹禾糠酯原药的高效液相色谱分析

采用高效液相色谱法对喹禾糠酯的总酯含量进行分析,流动相为乙腈-水(体积比为7:3),使用Hypersil C18色谱柱和具有可变波长的紫外检测器.该方法的标准偏差为0.29%,变异系数为0.32%,回收率为99.56%,线性相关系数为O.9999.     

A Quantitative Genetic Study of Sclerotinia Head Rot Resistance Introgressed from the Wild Perennial Helianthus maximiliani into Cultivated Sunflower (Helianthus annuus L.)

Sclerotinia head rot (HR), caused by Sclerotinia sclerotiorum, is an economically important disease of sunflower with known detrimental effects on yield and quality in humid climates worldwide. The objective of this study was to gain insight into the genetic architecture of HR resistance from a sunflower line HR21 harboring HR resistance introgressed from the wild perennial Helianthus maximiliani. An F₂ population derived from the cross of HA 234 (susceptible-line)/HR21 (resistant-line) was evaluated for HR resistance at two locations during 2019–2020. Highly significant genetic variations (p < 0.001) were observed for HR disease incidence (DI) and disease severity (DS) in both individual and combined analyses. Broad sense heritability (H²) estimates across environments for DI and DS were 0.51 and 0.62, respectively. A high-density genetic map of 1420.287 cM was constructed with 6315 SNP/InDel markers developed using genotype-by-sequencing technology. A total of 16 genomic regions on eight sunflower chromosomes, 1, 2, 10, 12, 13, 14, 16 and 17 were associated with HR resistance, each explaining between 3.97 to 16.67% of the phenotypic variance for HR resistance. Eleven of these QTL had resistance alleles from the HR21 parent. Molecular markers flanking the QTL will facilitate marker-assisted selection breeding for HR resistance in sunflower.