The Neurovascular Unit Dysfunction in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Histopathologically, AD presents with two hallmarks: neurofibrillary tangles (NFTs), and aggregates of amyloid β peptide (Aβ) both in the brain parenchyma as neuritic plaques, and around blood vessels as cerebral amyloid angiopathy (CAA). According to the vascular hypothesis of AD, vascular risk factors can result in dysregulation of the neurovascular unit (NVU) and hypoxia. Hypoxia may reduce Aβ clearance from the brain and increase its production, leading to both parenchymal and vascular accumulation of Aβ. An increase in Aβ amplifies neuronal dysfunction, NFT formation, and accelerates neurodegeneration, resulting in dementia. In recent decades, therapeutic approaches have attempted to decrease the levels of abnormal Aβ or tau levels in the AD brain. However, several of these approaches have either been associated with an inappropriate immune response triggering inflammation, or have failed to improve cognition. Here, we review the pathogenesis and potential therapeutic targets associated with dysfunction of the NVU in AD.     

A Brief Introduction on Joint Radar and Communication Systems

Joint radar and communication(JRC) technology is gradually becoming an essential approach to alleviating spectral congestion. Radar and communications systems were designed with common spectral and hardware resources to reduce size, improve performance, reduce cost, and decongest the spectrum. Various approaches have been proposed to achieve the coexistence of radar and communication systems. This paper mainly focuses on the research directions of radar communication coexistence(RCC) and dual-function radar communication systems(DFRC) in JRC technology. We summarize and analyze the existing research problems in the JRC era. According to the characteristics and advantages of JRC technology, we highlight several potentials in military and commercial applications.     

不同条件下尼龙材料光老化行为的研究

目前,氙灯加速老化试验是评估材料耐候效果最常用的一种方法。但是,关于该测试方法是否能客观反应材料实际使用过程中的颜色、力学变化规律的相关数据积累非常少。详细对比了两种测试条件对材料耐候效果的影响,结果表明,在定性评估方面,不同耐候剂组合在两种老化试验中的优劣顺序基本上保持一致,说明氙灯加速老化试验可以比较客观地反映材料在自然使用过程中的颜色变化;而定量方面,在老化初期,两种测试方法的结果比较接近;而随着老化时间的增长,氙灯老化条件下材料的色差开始呈现指数型增长,远远高于户外自然老化。造成上述现象的原因可能包括两点,一是氙灯老化测试时的温度更高,树脂和色粉等更容易发生降解;二是材料表面的耐候剂在氙灯测试中消耗过快,内部的耐候剂无法及时补充,因此造成自由基大量生成,导致老化加速进行。     

Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

Alzheimer’s disease (AD) is a neurodegenerative disease, characterized histopathologically by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in the brain parenchyma and around cerebral blood vessels. According to the vascular hypothesis of AD, an alteration in the neurovascular unit (NVU) could lead to Aβ vascular accumulation and promote neuronal dysfunction, accelerating neurodegeneration and dementia. To date, the effects of insoluble vascular Aβ deposits on the NVU and the blood–brain barrier (BBB) are unknown. In this study, we analyze different Aβ species and their association with the cells that make up the NVU. We evaluated post-mortem AD brain tissue. Multiple immunofluorescence assays were performed against different species of Aβ and the main elements that constitute the NVU. Our results showed that there are insoluble vascular deposits of both full-length and truncated Aβ species. Besides, insoluble aggregates are associated with a decrease in the phenotype of the cellular components that constitute the NVU and with BBB disruption. This approach could help identify new therapeutic targets against key molecules and receptors in the NVU that can prevent the accumulation of vascular fibrillar Aβ in AD.     

NiAl金属间化合物的热爆合成过程研究

以Al粉和Ni粉为主要原料，采用自蔓延高温合成技术，制备Ni—Al基金属间化合物。绘制了热爆反应曲线、描述了热爆反应的过程，分析了热爆反应机理及产物的显微组织特征，研究了热爆反应的边界条件以及各种反应参数对热爆反应的影响。研究结果表明，升温速率和颗粒尺寸对热爆反应均有不同程度的影响。提高升温速率、减小颗粒尺寸均可缩短热爆反应的起始时间，降低热爆反应的起始温度。初步确定了反应起始温度低于Ni—Al系的最低共晶温度（640℃），Ni—A1系的热爆反应是由固一固扩散反应引发的，Ni-32Al的反应产物为单相、均一的NiAl相。     

数控小孔冲床网眼平板加工中的波浪纹缺陷成因分析及排除

文章就数控小孔冲床加工纺织烘干设备中帘子网眼平板产生波浪纹缺陷的原因,进行了全面、详细的理论分析.在排除机床、模具精度影响的基础上,针对压料机构运动误差产生的机理和不利影响,详细分析了网眼冲孔加工产生波浪纹缺陷的根本原因,提出了相应的改进措施,在实践中具有良好的实用效果.     

Influence of the stress,strain, and temperature on the surface roughness of an AlSl 52100 steel due to an orthogonal cut

In recent years, the finite element method (FEM) has become the main tool for simulating the metal cutting process because research based on trial and error is time consuming and requires high investment. Early studies were done by different investigators. In this research AISI 52100, hardened steel (62 HRC) was selected for an orthogonal machining process as well as metal cutting simulation using the software DEFORM-2D. This software is based on a forging process and has been adapted to an orthogonal machining process. The results of simulated cutting forces were compared with experimental cutting force data to validate the orthogonal cut simulation. Also, the surface roughness was measured, and the influence of the stress, strain, and temperature on the surface roughness was studied.     

N-甲酰吗啉芳烃抽提塔试验研究

用小型碳钢筛板萃取塔进行了宽馏分重整脱庚烷油的N 甲酰吗啉抽提试验 ,考察了抽提温度、溶剂比、溶剂含水率对总芳烃收率及选择性的影响。结果表明 ,在抽提温度为 60℃、溶剂含水为 3 % (m )和溶剂比S/F =4(V)的抽提操作条件下 ,溶剂选择性较高 ,并可获得高的芳烃回收率